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- Osby, U, et al.
(författare)
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Mortality and causes of death in schizophrenia in Stockholm County, Sweden
- 2000
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Ingår i: Schizophrenia Research. - 0920-9964 .- 1573-2509. ; 45:1-2, s. 21-28
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Tidskriftsartikel (refereegranskat)abstract
- A study of mortality for all patients with a first hospital diagnosis of schizophrenia in Stockholm County, Sweden, during 1973 to 1995 was performed, by linking the in-patient register with the national cause-of-death register. Overall and cause-specific standardized mortality ratios (SMR) were calculated by 5-year age classes and 5-year calendar time periods. The number of excess deaths was calculated by reducing the observed number of deaths by those expected. Our results confirmed a marked increase in mortality in schizophrenia both in males and females. Natural (somatic) causes of death was the main cause of excess deaths, with more than half of the excess deaths in females, and almost half of the excess deaths in males. Suicide was the specific cause of the largest number of excess deaths in males, while in females it was cardiovascular disease. SMRs were increased in both natural and unnatural causes of death, with 2.8 for males and 2.4 for females for all deaths, but were highest in suicide with 15.7 for males and 19.7 for females, and in unspecified violence with 11.7 for males and 9.9 for females. SMRs in suicide were especially high in young patients in the first year after the first diagnosis.
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| 2. |
- Osby, U, et al.
(författare)
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Time trends in first admissions for schizophrenia and paranoid psychosis in Stockholm County, Sweden
- 2001
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Ingår i: Schizophrenia Research. - 0920-9964 .- 1573-2509. ; 47:2-3, s. 247-254
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Tidskriftsartikel (refereegranskat)abstract
- Several studies have reported decreasing time trends in first diagnosed schizophrenia patients. The aim of this: study was to analyze time trends for first admissions with a diagnosis of schizophrenia or a diagnosis of either schizophrenia or paranoid psychosis during 1978-1994 in Stockholm County, Sweden, with a population of around 1.8 million. Information about first psychiatric admission with the diagnosis schizophrenia or paranoid psychosis for residents of Stockholm County was obtained from the Swedish population-based psychiatric inpatient register. Age-adjusted average yearly changes in first hospitalization rates were estimated in a Poisson regression model. Time trends in first admission rates were calculated from 1978 to 1994, while admissions during 1971 to 1977 were observed only to eliminate later re-admissions. First admissions for schizophrenia declined by 1.9% annually for females and by 1.3% for males, while first admissions for schizophrenia and paranoid psychosis together were unchanged over the study period for both genders. Our results indicate that the incidence of schizophrenia and paranoid psychosis taken together was essentially the same over the studied time period in Stockholm County, and that the apparent decline in first admission rates for schizophrenia may be an effect of changes in clinical diagnosis over time.
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| 4. |
- El-Saadi, O, et al.
(författare)
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Paternal and maternal age as risk factors for psychosis: findings from Denmark, Sweden and Australia
- 2004
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Ingår i: Schizophrenia Research. - 0920-9964. ; 67:2-3, s. 227-236
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Tidskriftsartikel (refereegranskat)abstract
- Background: While the association between increased maternal age and congenital disorders has long been recognized, the offspring of older fathers are also at increased risk of congenital disorders related to DNA errors during spermatogenesis. Recent studies have drawn attention to an association between increased paternal age and increased risk of schizophrenia. The aim of the current study was to examine both paternal and maternal age as risk factors for the broader category of psychosis. Method: We used data from three sources examining psychosis: a population-based cohort study (Denmark), and two case-control studies (Sweden and Australia). Results: When controlling for the effect of maternal age, increased paternal age was significantly associated with increased risk of psychosis in the Danish and Swedish studies. The Australian study found no association between adjusted paternal age and risk of psychosis. When controlling for the effect of paternal age, younger maternal a-e was associated with an increased risk of psychoses in the Danish study alone. Conclusions: The offspring of older fathers are at increased risk of developing psychosis. The role of paternally derived mutations and/or psychosocial factors associated with older paternal age warrants further research. (C) 2003 Elsevier B.V. All rights reserved.
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| 6. |
- Selten, JP, et al.
(författare)
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No relationship between risk of schizophrenia and prenatal exposure to stress during the Six-Day War or Yom Kippur War in Israel
- 2003
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Ingår i: Schizophrenia Research. - 0920-9964. ; 63:1-2, s. 131-135
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Tidskriftsartikel (refereegranskat)abstract
- Aim: Maternal stress during pregnancy is a possible risk factor for schizophrenia in the offspring. Using data from the Israel Psychiatric Registry we examined the impact of wars in Israel. Method: Retrospective birth cohort study. Results: Relative risks for cohorts exposed to Six-Day War and Yom Kippur War were 0.98 (95% CI: 0.85-1.13) and 1.00 (0.86-1.16). Conclusion: The evidence for maternal stress as a risk factor for schizophrenia remains insufficient. (C) 2002 Elsevier Science B.V. All rights reserved.
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