SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "(LAR1:gu) lar1:(gu) srt2:(2000-2009) srt2:(2006)"

Sökning: (LAR1:gu) lar1:(gu) srt2:(2000-2009) > (2006)

  • Resultat 1-10 av 5974
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  •  
2.
  •  
3.
  •  
4.
  •  
5.
  • Abdulle, Sahra, 1970 (författare)
  • HIV-1 infection of the central nervous system. Markers of pathogenesis and antiretroviral treatment effects
  • 2006
  • Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
    • Human immunodeficiency virus type 1 (HIV-1) invades the central nervous system (CNS) early in the course of infection and either directly or through opportunistic infections causes a spectrum of neurological complications. The most severe manifestation of HIV-1 CNS infection is AIDS Dementia Complex (ADC), which occurs in approximately 20% of untreated patients with AIDS. ADC is considered the result of a complex interplay between immune activation effects and viral replication in the brain, which ultimately leads to neuronal injury and death. Reliable markers to diagnose HIV-1 associated CNS injury, track disease progression, and identify patients at risk of developing ADC are lacking. Such markers would also be beneficial in evaluating the efficacy of antiretroviral treatment (ART) in the CNS, as well as to provide insights into the pathogenesis of HIV-1 CNS infection.HIV-1 elicits intrathecal cell-mediated and humoral immune activation. We found that ART effectively decreased the cerebrospinal fluid (CSF) concentrations of neopterin and beta2-microglobulin, but had little effect on the elevated IgG index. However, almost half of the patients still had slightly elevated levels of neopterin after 2 years of follow-up. Phylogenetic analyses have identified 3 distinct HIV-1 genetic groups. Group M, which is responsible for most of the global HIV-1 epidemic is further subdivided into subtypes and circulating recombinant forms (CRFs). Most of the current knowledge of HIV-1 CNS infection is based on studies of subtype B, which is predominant in the western world. However, subtypes other than subtype B are responsible for most of the epidemic outside the western world, and HIV-1 infections due to subtypes other than B are rapidly increasing across Europe. Markers of HIV-1 CNS infection such as HIV-1 RNA, neopterin, and white blood cell (WBC) count in CSF were measured and compared in patients infected with different HIV-1 subtypes. We did not find any significant subtype-specific differences in the neuromarkers evaluated in this study. Thus, subtypes do not appear to influence neuropathogenesis.Although there is no evidence of productive infection of neurons the end-result of HIV-1 CNS infection is neuronal damage and loss. We investigated the potential of CSF neurofilament (NFL), a sensitive indicator of axonal injury, as a marker of HIV-1 associated neurodegeneration. CSF NFL concentrations were higher in patients with ADC than in neuroasymptomatic patients, or patients with primary HIV-1 infection. Patients with severe ADC had higher CSF NFL levels compared to those with milder disease. CSF NFL declined with ART to the limit of detection in parallel with virological response and neurological improvement in patients suffering from ADC.Neurocognitive impairment remains a major concern in HIV-1 infection despite the success of ART. Studies on the pathogenesis, epidemiology, and the effects of ART on HIV-1 CNS infection are important to improve patient management.
  •  
6.
  •  
7.
  • Abildgaard, Lotte, et al. (författare)
  • Optimal treatment intensity in children with Down syndrome and myeloid leukaemia: data from 56 children treated on NOPHO-AML protocols and a review of the literature.
  • 2006
  • Ingår i: Annals of hematology. - : Springer Science and Business Media LLC. - 0939-5555 .- 1432-0584. ; 85:5, s. 275-80
  • Tidskriftsartikel (refereegranskat)abstract
    • Children with Down syndrome (DS) and myeloid leukaemia have a significantly higher survival rate than other children, but they also experience considerable treatment-related toxicity. We analysed data on 56 children with DS who were treated on the Nordic Society for Paediatric Haematology and Oncology-acute myeloid leukaemia (NOPHO-AML)88 and NOPHO-AML93 protocols and reviewed the literature. In the dose-intensive NOPHO-AML88 protocol, 8 out of 15 patients (53%) experienced an event. In the less dose-intensive NOPHO-AML93 protocol, 7 out of 41 patients (17%) had an event. Therapy was reduced in 29 patients (52%) with in average 75% and 67% of the scheduled dose of anthracycline and cytarabine, respectively. Treatment-related death occurred in seven who all received full treatment. Relapse and resistant disease occurred at a similar rate in those receiving full and reduced treatment. Review of major series of myeloid leukaemia of DS showed no clear relationship between dose and survival; however, it appears that both a reduction in treatment dose and a less intensively timed treatment regimen improved the outcome. Further studies are needed to define the optimal regimen for treating myeloid leukaemia of DS.
  •  
8.
  • Abiri, Elisabeth, 1962 (författare)
  • Let’s talk! Human Rights meet Peace and Security
  • 2006
  • Rapport (övrigt vetenskapligt/konstnärligt)abstract
    • The report focuses on the links between two fields of theories and practices - human rights and peace and security - that appear to have much in common. To be able to find durable solutions to conflicts human rights must be guaranteed, and in order to safeguard human rights violent conflicts must be kept at bay. The report's aim is to enhance knowledge and discussion about the relationship between human rights and peace and security in theory and practice, and to form the base for further work on how development cooperation may develop human rights promoting and conflict sensitive practices.
  •  
9.
  •  
10.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 1-10 av 5974
Typ av publikation
tidskriftsartikel (3087)
konferensbidrag (814)
bokkapitel (715)
rapport (389)
doktorsavhandling (274)
bok (170)
visa fler...
recension (144)
annan publikation (132)
samlingsverk (redaktörskap) (110)
forskningsöversikt (76)
licentiatavhandling (38)
konstnärligt arbete (23)
patent (2)
proceedings (redaktörskap) (1)
visa färre...
Typ av innehåll
refereegranskat (3082)
övrigt vetenskapligt/konstnärligt (2878)
populärvet., debatt m.m. (14)
Författare/redaktör
Lundälv, Jörgen, 196 ... (62)
Grub, Frank Thomas, ... (45)
Stibrant Sunnerhagen ... (32)
Chen, Deliang, 1961 (29)
Blennow, Kaj, 1958 (28)
Nyman, Eva, 1949- (27)
visa fler...
Rosen, Astrid von, 1 ... (26)
Jönsson, Love, 1975 (25)
Herlitz, Johan, 1949 (23)
Gärling, Tommy, 1941 (22)
Carlsson, Ulla, 1950 (21)
Swedberg, Karl, 1944 (20)
Olausson, Michael, 1 ... (19)
Granhag, Pär-Anders, ... (19)
Weibull, Lennart, 19 ... (19)
Ohlsson, Claes, 1965 (18)
Fahlke, Claudia, 196 ... (18)
Arvidsson, Kristoffe ... (18)
Kärrholm, Johan, 195 ... (18)
Campbell, Eleanor E ... (18)
Gillberg, Christophe ... (17)
Pramling Samuelsson, ... (17)
Milsom, Ian, 1950 (16)
Johansson, Bengt, 19 ... (15)
Karlsson, Jón, 1953 (15)
Hagberg, Henrik, 195 ... (15)
Söderbaum, Fredrik, ... (15)
Friman, Styrbjörn, 1 ... (15)
Albrektsson, Tomas, ... (15)
Skoog, Ingmar, 1954 (14)
Svennerholm, Ann-Mar ... (14)
Steineck, Gunnar, 19 ... (14)
Johannsson, Gudmundu ... (14)
Ekman, Inger, 1952 (14)
Tullborg, Eva-Lena (14)
Häggström, Olle, 196 ... (14)
Bengtsson, Jan, 1949 (14)
Bjereld, Ulf, 1957 (14)
Peterson, Abby, 1949 (14)
Zetterberg, Henrik, ... (13)
Wallin, Anders, 1950 (13)
Ahlman, Håkan, 1947 (13)
Wennergren, Göran, 1 ... (13)
Willander, Magnus, 1 ... (13)
Thomsen, Peter, 1953 (13)
Sterner, Thomas, 195 ... (13)
Johansson, Boo (13)
Dahlöf, Björn, 1953 (13)
Lindblad, Sverker, 1 ... (13)
Nilsson, Lennart, 19 ... (13)
visa färre...
Lärosäte
Göteborgs universitet (5974)
Chalmers tekniska högskola (405)
Karolinska Institutet (166)
Lunds universitet (129)
Uppsala universitet (128)
Umeå universitet (84)
visa fler...
Linköpings universitet (70)
Högskolan i Borås (42)
Kungliga Tekniska Högskolan (30)
Örebro universitet (27)
Högskolan i Skövde (27)
Karlstads universitet (26)
Mittuniversitetet (25)
Jönköping University (22)
Linnéuniversitetet (21)
Högskolan i Halmstad (20)
Högskolan Väst (17)
Stockholms universitet (11)
Högskolan Dalarna (10)
Luleå tekniska universitet (9)
Mälardalens universitet (7)
Södertörns högskola (7)
Marie Cederschiöld högskola (6)
Högskolan Kristianstad (4)
Högskolan i Gävle (4)
Handelshögskolan i Stockholm (4)
RISE (4)
Malmö universitet (3)
Naturhistoriska riksmuseet (2)
Blekinge Tekniska Högskola (2)
Nordiska Afrikainstitutet (1)
Naturvårdsverket (1)
Gymnastik- och idrottshögskolan (1)
Riksantikvarieämbetet (1)
VTI - Statens väg- och transportforskningsinstitut (1)
visa färre...
Språk
Engelska (4201)
Svenska (1549)
Tyska (115)
Odefinierat språk (38)
Franska (24)
Spanska (17)
visa fler...
Norska (8)
Danska (3)
Ryska (3)
Italienska (2)
Nederländska (2)
Tjeckiska (2)
Finska (1)
Polska (1)
Portugisiska (1)
Ungerska (1)
Nygrekiska (1)
Kinesiska (1)
Slovenska (1)
Bosniska (1)
visa färre...
Forskningsämne (UKÄ/SCB)
Samhällsvetenskap (1923)
Medicin och hälsovetenskap (1375)
Naturvetenskap (1211)
Humaniora (981)
Teknik (94)
Lantbruksvetenskap (33)
År

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy