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Insulin Resistance ...
Insulin Resistance is Associated with Higher Cerebrospinal Fluid Tau Levels in Asymptomatic APOE epsilon 4 Carriers
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Starks, E. J. (author)
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O'Grady, J. P. (author)
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Hoscheidt, S. M. (author)
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Racine, A. M. (author)
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Carlsson, C. M. (author)
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- Zetterberg, Henrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Blennow, Kaj, 1958 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Okonkwo, O. C. (author)
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Puglielli, L. (author)
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Asthana, S. (author)
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Dowling, N. M. (author)
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Gleason, C. E. (author)
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Anderson, R. M. (author)
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Davenport-Sis, N. J. (author)
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DeRungs, L. M. (author)
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Sager, M. A. (author)
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Johnson, S. C. (author)
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Bendlin, B. B. (author)
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(creator_code:org_t)
- IOS Press, 2015
- 2015
- English.
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In: Journal of Alzheimers Disease. - : IOS Press. - 1387-2877 .- 1875-8908. ; 46:2, s. 525-533
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https://gup.ub.gu.se...
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https://doi.org/10.3...
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Abstract
Subject headings
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- Background: Insulin resistance (IR) is linked with the occurrence of pathological features observed in Alzheimer's disease (AD), including neurofibrillary tangles and amyloid plaques. However, the extent to which IR is associated with AD pathology in the cognitively asymptomatic stages of preclinical AD remains unclear. Objective: To determine the extent to which IR is linked with amyloid and tau pathology in late-middle-age. Method: Cerebrospinal fluid (CSF) samples collected from 113 participants enrolled in the Wisconsin Registry for Alzheimer's Prevention study (mean age = 60.6 years), were assayed for AD-related markers of interest: A beta(42), P-Tau(181), and T-Tau. IR was determined using the Homeostatic Model Assessment for Insulin Resistance (HOMA-IR). Linear regression was used to test the effect of IR, and APOE epsilon 4, on tau and amyloid pathology. We hypothesized that greater IR would be associated with higher CSF P-Tau181 and T-Tau, and lower CSF A beta 42. Results: No significant main effects of HOMA-IR on P-Tau181, T-Tau, or A beta 42 were observed; however, significant interactions were observed between HOMA-IR and APOE epsilon 4 on CSF markers related to tau. Among APOE epsilon 4 carriers, higher HOMA-IR was associated with higher P-Tau181 and T-Tau. Among APOE epsilon 4 non-carriers, HOMA-IR was negatively associated with P-Tau181 and T-Tau. We found no effects of IR on A beta 42 levels in CSF. Conclusion: IR among asymptomatic APOE epsilon 4 carriers was associated with higher P-Tau(181) and T-Tau in late-middle age. The results suggest that IR may contribute to tau-related neurodegeneration in preclinical AD. The findings may have implications for developing prevention strategies aimed at modifying IR in mid-life.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Alzheimer's disease
- apolipoprotein epsilon 4
- cerebrospinal fluid
- glucose
- insulin
- insulin resistance
- SPORADIC ALZHEIMERS-DISEASE
- HOMEOSTASIS MODEL ASSESSMENT
- MILD
- COGNITIVE IMPAIRMENT
- AMYLOID PRECURSOR PROTEIN
- APOLIPOPROTEIN-E
- GENOTYPE
- IMPROVES COGNITION
- GLUCOSE-METABOLISM
- IN-VIVO
- HOMA-IR
- BRAIN
- Neurosciences
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Starks, E. J.
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O'Grady, J. P.
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Hoscheidt, S. M.
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Racine, A. M.
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Carlsson, C. M.
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Zetterberg, Henr ...
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show more...
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Blennow, Kaj, 19 ...
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Okonkwo, O. C.
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Puglielli, L.
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Asthana, S.
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Dowling, N. M.
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Gleason, C. E.
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Anderson, R. M.
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Davenport-Sis, N ...
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DeRungs, L. M.
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Sager, M. A.
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Johnson, S. C.
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Bendlin, B. B.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Journal of Alzhe ...
- By the university
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University of Gothenburg