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24th Anniversary World Congress on Biosensors – Biosensors 2014
- 2014
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Proceedings (redaktörskap) (refereegranskat)abstract
- Welcome to Biosensors 2014 and welcome to Melbourne, ranked as the world's most liveable city!This is the 24th anniversary edition of the World Congress on Biosensors and we continue to evolve, adapt and grow into new roles to serve the analytical needs of a rapidly changing society. Advances in telecommunications, expert systems and distributed diagnostics are prompting us to question the conventional ways we deliver healthcare, while robust industrial sensors are facilitating new paradigms in R&D and production. Personalisation of everything from medicine to environmental control, is giving new impetus to consumer choice and ownership of information, and will inevitably generate new payment structures and business models. Moreover, a deeper understanding of the bio/electronic interface leads us towards new horizons in areas such as bionics, power generation and computing. Wearable, mobile and integrated sensors are becoming common place, but most current products have taken the easy path of incorporating physical sensors for parameters such as temperature, pressure, orientation or position. There is still a glaring absence of suitably robust and convenient commercial biosensors for body chemistries and ecosystems, and therein lies the real opportunities for progress. We are a still-emerging technology that is fuelling scientific discovery and underpinning new products to enhance the length and quality of life.Always in a new country and always with fresh plenary speakers, we aim to reflect the latest and the best in Biosensors. This three-day event, organised by Elsevier in association with Biosensors & Bioelectronics, consists of two daily plenary presentations from leading figures in the field, followed by four parallel sessions, comprising a rigorously refereed selection of submitted papers. This year, we received 1,156 submissions of which 124 with be presented as regular Oral papers, with an additional 20 singled out as Invited talks and a further 12 selected for extended Keynote talks. The Keynote speakers have also been invited to submit full papers for consideration for the Biosensors and Bioelectronics Prize for the most original contribution to the Congress and the winners will be announced at the conference banquet on Thursday night. There will also be poster awards and you will find voting slips for each of the three days in your delegate bags. The winners of these awards and a prize draw, sponsored by Linköping University and Acreo Swedish ICT, will be announced at the closing ceremony on Friday. In order to enhance the valued medium of poster presentation, this year we have introduced a new Poster in my Pocket Ap. Poster presenters have been able to upload a PDF of their poster prior to the conference to help increase the exposure of their work. This compliments the other new Ap introduced this year to place the full programme at your fingertips. Selected oral presentations will also have the opportunity to upload their talks online for future viewing.The academic programme, as usual, is enhanced by a fine collection of commercial exhibits and in addition to browsing their stands; you will be able to hear short elevator pitches during the breaks. We must thank our main commercial sponsor, Ercon for their generous and continued support of our congress. Thanks also to New Tools for Health for sponsoring the pre-congress Networking Event. Now a regular feature for Biosensors, we have a pre-congress school, this year on Optical Biosensors, which is brought to you by Profs Fran Ligler and Tanya Monro. Last, but not least I must thank our marvellous Local Organising Committee chaired by Prof Justin Gooding, our hard working main Organising Committee, all the speakers and delegates, and the Elsevier team for all their support.Our delegates come from the four corners of the globe to hear the science, to grasp the opportunities and to meet the people; it’s going to be the best meeting yet. Enjoy and don’t forget to join us again in Gothenburg, Sweden, 24-27 May for Biosensor 2016!
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- A Atlasov, Kirill, et al.
(författare)
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1D photonic band formation and photon localization in finite-size photonic-crystal waveguides
- 2010
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Ingår i: OPTICS EXPRESS. - 1094-4087. ; 18:1, s. 117-122
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Tidskriftsartikel (refereegranskat)abstract
- A transition from discrete optical modes to 1D photonic bands is experimentally observed and numerically studied in planar photonic-crystal (PhC) L-N microcavities of length N. For increasing N the confined modes progressively acquire a well-defined momentum, eventually reconstructing the band dispersion of the corresponding waveguide. Furthermore, photon localization due to disorder is observed experimentally in the membrane PhCs using spatially resolved photoluminescence spectroscopy. Implications on single-photon sources and transfer lines based on quasi-1D PhC structures are discussed.
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- A Herrera, I, et al.
(författare)
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Comparing a multi-linear (STEP) and systemic (FRAM) method for accident analysis
- 2010
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Ingår i: RELIABILITY ENGINEERING and SYSTEM SAFETY. - London, UK : Elsevier Science B.V., Amsterdam.. - 0951-8320. ; 95:12, s. 1269-1275, s. 19-26
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Tidskriftsartikel (refereegranskat)abstract
- Accident models and analysis methods affect what accident investigators look for, which contributory factors are found, and which recommendations are issued. This paper contrasts the Sequentially Timed Events Plotting (STEP) method and the Functional Resonance Analysis Method (FRAM) for accident analysis and modelling. The main issue addressed in this paper is the comparison of the established multi-linear method STEP with the new systemic method FRAM and which new insights the latter provides for accident analysis in comparison to the former established multi-linear method. Since STEP and FRAM are based on a different understandings of the nature of accidents, the comparison of the methods focuses on what we can learn from both methods, how, when, and why to apply them. The main finding is that STEP helps to illustrate what happened, involving which actors at what time, whereas FRAM illustrates the dynamic interactions within socio-technical systems and lets the analyst understand the how and why by describing non-linear dependencies, performance conditions, variability, and their resonance across functions.
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- A Hulten, Maj, et al.
(författare)
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On the origin of the maternal age effect in trisomy 21 Down syndrome: the Oocyte Mosaicism Selection model
- 2010
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Ingår i: Reproduction. - 1470-1626 .- 1476-3990. ; 139:1, s. 1-9
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Forskningsöversikt (refereegranskat)abstract
- We have recently documented that trisomy 21 mosaicism is common in human foetal ovaries. On the basis of this observation we propose that the maternal age effect in Down syndrome (DS) is caused by the differential behaviour of trisomy 21 in relation to disomy 21 oocytes during development from foetal life until ovulation in adulthood. in particular, we suggest that trisomy 21 oocytes, lagging behind those that are disomic, may escape the timed pruning of the seven million in foetal life to the 300-400 finally selected for ovulation. The net effect of this preferential elimination will be an accumulation of trisomy 21 oocytes in the ovarian reserve of older women. We here highlight the implications of this Oocyte Mosaicism Selection (OMS) model with respect to the prevalent view that the maternal age effect is complex, dependent on many different biological and environmental factors. We examine conclusions drawn from recent large-scale studies in families, tracing DNA markers along the length of chromosome 21q between parents and DS children, in comparison to the OMS model. We conclude that these family linkage data are equally compatible with the maternal age effect originating from the accumulation of trisomy 21 oocytes with advancing maternal age. One relatively straightforward way to get to grips with what is actually going on in this regard would be to compare incidence of trisomy 21 oocytes (and their pairing configurations) in foetal ovaries with that in oocytes at the meiosis I stage from adult women.
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- A. Strumpfer, Johan, et al.
(författare)
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Stretching of Twitchin Kinase
- 2012
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Ingår i: Biophysical Journal. - St. Louis, MO, United States : Cell Press. - 0006-3495 .- 1542-0086. ; 102:3 Supplement 1, s. 361a-362a
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Tidskriftsartikel (refereegranskat)abstract
- The giant proteins from the titin family, that form cytoskeletal filaments, have emerged as key mechanotransducers in the sarcomere. These proteins contain a conserved kinase region, which is auto-inhibited by a C-terminal tail domain. The inhibitory tail domain occludes the active sites of the kinases, thus preventing ATP from binding. It was proposed that through application of a force, such as that arising during muscle contraction, the inhibitory tail becomes detached, lifting inhibition. The force-sensing ability of titin kinase was demonstrated in AFM experiments and simulations [Puchner, et al., 2008, PNAS:105, 13385], which showed indeed that mechanical forces can remove the autoinhibitory tail of titin kinase. We report here steered molecular dynamics simulations (SMD) of the very recently resolved crystal structure of twitchin kinase, containing the kinase region and flanking fibronectin and immuniglobulin domains, that show a variant mechanism. Despite the significant structural and sequence similarity to titin kinase, the autoinhibitory tail of twitchin kinase remains in place upon stretching, while the N-terminal lobe of the kinase unfolds. The SMD simulations also show that the detachment and stretching of the linker between fibronectin and kinase regions, and the partial extension of the autoinhibitory tail, are the primary force-response. We postulate that this stretched state, where all structural elements are still intact, may represent the physiologically active state.
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- Aaboen, Lise
(författare)
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BATON-CHANGING ON EGGSHELLS – TRANSFERRING SUPPLIER RELATIONSHIPS WHEN MOVING PRODUCTION
- 2014
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Konferensbidrag (refereegranskat)abstract
- Production transfers are a result of outsourcing and offshoring decisions. Though, because ofthe strategic focus of the outsourcing literature have not the operational issues of howrelationship development between sender, receiver and raw material been fully depicted. Thepurpose of the present paper is to explore relationship development connected to transfer ofraw material supplies responsibility during transfer of production. To fulfil the purpose, fourdifferent production transfers were studied: three from Sweden to China, Romania andHungary respectively and one transfer from Holland to Sweden. We can see that thedependence and power shifts gradually between the sender and the receiver and therelationship between them sets the arena for what relationship is developed between thereceiver and the raw material suppliers. Furthermore, short social distances can over bridgecultural and technological distances to some extent, because it motivates to take therelationship into a more developed state.
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