| 1. |
- Abdel-Motal, Ussama M., et al.
(författare)
-
Major histocompatibility complex class I binding glycopeptides for the estimation of 'empty' class I molecules
- 1995
-
Ingår i: Journal of Immunological Methods. - : Elsevier BV. - 0022-1759. ; 188:1, s. 21-31
-
Tidskriftsartikel (refereegranskat)abstract
- Different forms of major histocompatibility complex (MHC) class I heavy chains are known to be expressed on the cell surface, including molecules which are functionally 'empty'. Direct peptide binding to cells is obvious during sensitization of target cells in vitro for cytotoxic T lymphocyte killing and 'empty' MHC-I molecules are comparatively abundant on TAP- 1 2 peptide transporter mutant cells. In the present work we have estimated the fraction of 'empty' MHC class I molecules using glycosylated peptides and cellular staining with carbohydrate specific monoclonal antibodies. Synthetic Db and Kb binding peptides were coupled at different positions with different di- or trisaccharides, using different spacing between the carbohydrate and the peptide backbone. Binding of sugar specific mAbs was compared in ELISA and cellular assays. An optimal Db binding glycopeptide was used for comparative staining with anti-Db and anti-carbohydrate monoclonal antibodies to estimate fractions of 'empty' molecules on different T lymphoid cells. On activated normal T cells, a large fraction of Db molecules were found to be 'empty'. The functional cole of such 'empty' MHC class I molecules on T cells is presently unclear. However, on antigen presenting cells they might participate in the antigen presentation process.
|
|
| 2. |
|
|
| 3. |
- Abramowicz, H., et al.
(författare)
-
The Physics case for a forward detector upgrade
- 1995
-
Ingår i: Future physics at HERA. Proceedings, Workshop, Hamburg, Germany, September 25, 1995-May 31, 1996. Vol. 1, 2.
-
Konferensbidrag (övrigt vetenskapligt/konstnärligt)
|
|
| 4. |
|
|
| 5. |
- Adalberth, Karin
(författare)
-
Bygga - Bruka - Riva : Energianvändning i småhus ur ett kretsloppsperspektiv
- 1995
-
Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This report deals with single-unit dwellings built in 1991 and 1992 in a city called Orebro, Sweden.The houses are prefabricated and the frameworks are made of wood. The aim of the essay is to present the total use of energy during the life-cycle of single-unit dwellings, taking their mode of construction into account. The life-cycle of a house is divided into the following periods: production (manufacturing of the building materials, transportation of the materials and erection of the single-unit dwellings);· management (occupation and renovation); and, finally, destruction (demolition and removal of debris). The management period is assumed to be 50 years.
|
|
| 6. |
- Adamovich, M.I., et al.
(författare)
-
Charged particle multiplicity and pseudorapidity density distributions in 16O-, 28Si- and 197Au-induced nuclear interactions at 14.6 and 11.6A GeV/c
- 1995
-
Ingår i: Nuclear Physics, Section A. - : Elsevier BV. - 0375-9474. ; 593:4, s. 535-549
-
Tidskriftsartikel (refereegranskat)abstract
- Pseudorapidity density and multiplicity distributions of charged particles produced in heavy-ion collisions at the BNL AGS have been studied. The multiplicity distributions and pseudorapidity distributions of shower particles in Au-induced interactions are presented and compared with model predictions from RQMD, FRITIOF and VENUS. It is shown that the widths of the pseudorapidity distributions of produced particles in central collisions are independent of the interacting system. The results from EMU01 have been compared, and found to agree, with the results from two other heavy-ion experiments, E802 and E814.
|
|
| 7. |
- Adamovich, M.I., et al.
(författare)
-
Rescattering probed by the emission of slow target associated particles in high-energy heavy-ion interactions
- 1995
-
Ingår i: Physics Letters. Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier BV. - 0370-2693. ; 363:4, s. 230-236
-
Tidskriftsartikel (refereegranskat)abstract
- In this letter the distribution of slow target associated particles emitted in Au + Emulsion interactions at 11.6 A GeV/c is studied, The three models RQMD, FRITIOF and VENUS are used for comparisons and especially their treatment of rescattering is investigated.
|
|
| 8. |
|
|
| 9. |
- Adner, Mikael, et al.
(författare)
-
Upregulation of a non-ETA receptor in human arteries in vitro
- 1995
-
Ingår i: Journal of Cardiovascular Pharmacology. - 1533-4023. ; 26:Suppl. 3, s. 314-316
-
Tidskriftsartikel (refereegranskat)abstract
- Receptor turnover may be a crucial part in the physiology of endothelin (ET). Incubation of vessel segments could be a possible method to demonstrate this. The aim was to study contractile responses of human omental arteries to different ET agonists at various periods after incubation at 37 degrees C in 5% CO2 and air. The maximum effect (Emax; percentage of contraction to 60 mM K+ buffer solution) and the potency of ET-1 were unaltered (pD2 = 8.82 +/- 0.06). The selective ETB agonist IRL 1620 demonstrated a negligible Emax in nonincubated segments (2.4 +/- 0.9%). After only 1 day of incubation the Emax was 51 +/- 23%, and it reached 114 +/- 53% after 5 days. The pD2 of IRL 1620 was stable throughout the incubation time (7.23 +/- 0.08). ET-3 showed a moderate Emax in nonincubated segments (55 +/- 18%), with a pD2 of 6.68 +/- 0.24. However, subsequent incubation revealed an increase of pD2 to 8.60 +/- 0.20 on the fifth day. The maximum contraction increased to 206 +/- 44%; this is equal to the contraction obtained in paired experiments with ET-1 (215 +/- 18%). These findings indicate modulation of endothelin receptor expression after incubation of vessel segments, and suggest the gradual appearance of a non-ETA receptor.
|
|
| 10. |
- Adolfsson, C, et al.
(författare)
-
Cutting force model for multi-toothed cutting processes and force measurement equipment for face milling
- 1995
-
Ingår i: International Journal of Machine Tools & Manufacture. - 0890-6955. ; 35:12, s. 1715-1728
-
Tidskriftsartikel (refereegranskat)abstract
- This article presents a mechanical cutting force model for multi-tooth cutting processes, where initial position errors in radial and axial direction, eccentricity and edge wear are taken into account. The cutting forces are presented for each individual cutting edge, and in a system of coordinates where one axis is parallel to the cutting speed vector at any instant. The process parameter cutting resistance, Cr is derived from the measured main cutting force FM. Cr should be regarded as a parameter since it is always increasing with decreasing values of theoretical chip thickness h1. A new way of measuring cutting forces in multi-tooth cutting processes is also presented. Eight cutting force components are measured on the tool close to each of the four cutting edges. The aroused signals are filtered, amplified, A/D-converted and put together in a serial stream for transmission through a hollow spindle via a fibre optic cable. The signals are sent from the rotating spindle to the frame of the machine over an air gap with Light Emitting Diodes. They are then demultiplexed, D/A-converted, and stored in a PC-based eight channel oscilloscope. With this measurement equipment it is possible to directly measure the cutting forces acting on each individual cutting edge.
|
|
