| 1. |
- Björn, Inger, 1953-, et al.
(author)
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Drug related negative side effects is a common reason for poor compliance in hormone replacement therapy
- 1999
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In: Maturitas. - : Elsevier. - 0378-5122 .- 1873-4111. ; 32:2, s. 77-86
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Journal article (peer-reviewed)abstract
- Objectives: The reasons for poor compliance with hormone replacement therapy (HRT) and, in particular drug-related reasons, have not yet been fully elucidated. In this study, a cohort of peri- or postmenopausal women—mainly workers from a small town and surrounding rural area—was studied. The aim of the study was to investigate why some women never start or discontinue HRT, even when great effort has been made to inform and fulfill the demands of the patient. Methods: All women who were given a HRT prescription at a gynecological practice between September 1991 and December 1992 participated in a longitudinal study. A written questionnaire was mailed to these patients in 1996. Data from the questionnaire was supplemented with information from the medical records. Care of patients included initial information, follow-up within 4 months, yearly visits supplemented with contacts on demand. Results: 356 women received the questionnaire, among which 92% replied. A total of 2% never started HRT. Seventy-five percent continued the therapy for more than 3 years. Reasons for discontinuing HRT were negative side-effects (35%), desire to find out if climacteric symptoms had ended (26%), fear of cancer and thrombosis (25%), weariness of bleeding (19%) and a wish to deal with the problems ‘naturally’ (15%). Conclusions: Compliance with HRT can be high if adequate information is given and follow-ups are made. The main reason for poor compliance was negative side-effects, most likely progestin-related. The results of this study suggest that the future challenge will be to minimize negative side-effects of HRT.
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| 2. |
- Kurlberg, Pär, et al.
(author)
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Superscars in the Seba billiard
- 2017
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In: Journal of the European Mathematical Society (Print). - 1435-9855 .- 1435-9863.
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Journal article (peer-reviewed)
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| 3. |
- Malyarenko, Anatoliy, 1957-
(author)
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Spectral expansions of cosmological fields
- 2015
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In: Journal of Statistical Science and Application. - Libertyville, IL, USA : David Publishing Company. - 2328-224X. ; 3:11-12, s. 175-193
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Journal article (peer-reviewed)abstract
- We give a review of the theory of random fields defined on the observable part of the Universe that satisfy the cosmological principle, i.e.,invariant with respect to the 6-dimensional group G of theisometries of the time slice of theFriedmann-Lemaitre-Robertson-Walker standard chart. Our new results include proof of spectral expansions of scalar and spin weighted G-invariant cosmological fields in open, flat, and closed cosmological models.
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| 4. |
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| 5. |
- Platz, Daniel, et al.
(author)
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Interpreting motion and force for narrow-band intermodulation atomic force microscopy
- 2013
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In: Beilstein Journal of Nanotechnology. - : Beilstein Institut. - 2190-4286. ; 4, s. 45-56
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Journal article (peer-reviewed)abstract
- Intermodulation atomic force microscopy (ImAFM) is a mode of dynamic atomic force microscopy that probes the nonlinear tip-surface force by measurement of the mixing of multiple modes in a frequency comb. A high-quality factor cantilever resonance and a suitable drive comb will result in tip motion described by a narrow-band frequency comb. We show, by a separation of time scales, that such motion is equivalent to rapid oscillations at the cantilever resonance with a slow amplitude and phase or frequency modulation. With this time-domain perspective, we analyze single oscillation cycles in ImAFM to extract the Fourier components of the tip-surface force that are in-phase with the tip motion (F-I) and quadrature to the motion (F-Q). Traditionally, these force components have been considered as a function of the static-probe height only. Here we show that F-I and F-Q actually depend on both static-probe height and oscillation amplitude. We demonstrate on simulated data how to reconstruct the amplitude dependence of F-I and F-Q from a single ImAFM measurement. Furthermore, we introduce ImAFM approach measurements with which we reconstruct the full amplitude and probe-height dependence of the force components F-I and F-Q, providing deeper insight into the tip-surface interaction. We demonstrate the capabilities of ImAFM approach measurements on a polystyrene polymer surface.
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| 6. |
- Rampazzo, Roberto, et al.
(author)
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Extragalactic Astronomy : From Pioneers to Big Science
- 2016
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In: From the Realm of the Nebulae to Populations of Galaxies. - Cham : Springer. - 9783319310046 - 9783319310060 ; , s. 1-92
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Book chapter (peer-reviewed)abstract
- At the beginning of the nineteenth century one of the scientific issues driving the research of astronomers, like the Herschels, was to test if all the nebulæ can be resolved into stars.
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| 7. |
- Schmidtchen, Artur, et al.
(author)
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Differential proteinase expression by Pseudomonas aeruginosa derived from chronic leg ulcers
- 2001
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In: Acta Dermato-Venereologica. - : Medical Journals Sweden AB. - 1651-2057 .- 0001-5555. ; 81:6, s. 406-409
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Journal article (peer-reviewed)abstract
- Pseudomonas aeruginosa colonizes 20-30% of all venous leg ulcers. Hypothetically, P. aeraginosa could release proteases and cytotoxic substances in the environment of chronic ulcers, thus negatively affecting the wound-healing activity in this patient group. Here we show that P. aeruginosa isolates from leg ulcers exhibit a highly variable expression of the proteinases elastase and alkaline proteinase. We propose that bacterial phenotype should be taken into account in future studies on the clinical outcome of leg ulcers colonized by P. aeruginosa.
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| 8. |
- Wentemi Apeaning, Raphael, et al.
(author)
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Barriers to and driving forces for industrial energy efficiency improvements in African industries : a case study of Ghana's largest industrial area
- 2013
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In: Journal of Cleaner Production. - : Elsevier BV. - 0959-6526 .- 1879-1786. ; 53, s. 204-213
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Journal article (peer-reviewed)abstract
- Barriers to industrial energy efficiency improvements in developing countries are more pronounced due to the existence of factors like weak energy policy frameworks, financial constraints, weak information systems and many more. This study is an explorative and qualitative research aimed at enhancing the knowledge of industrial energy efficiency and management strategies in Ghana, by investigating the barriers to and the driving forces for the implementation of energy efficiency measures in Ghana's largest industrial area. Results from the study revealed that energy is poorly managed in the various industries and that there is an energy efficiency gap resulting from the low implementation of energy efficiency measures. In addition, the study revealed that the most important factors impeding the implementation of cost effective energy efficiency technologies in the firms are principally economic (or market) barriers like “lack of budget funding” and “access to capital”. The study also shows that these economic barriers are linked to the lack of adequate government framework for industrial energy efficiency. The study also revealed that market factors related to “cost reductions resulting from lowered energy use” and “threats of rising energy prices” are the most important drivers for implementing energy efficiency measures or technologies.
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| 9. |
- Wenthe, Jessica, et al.
(author)
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Boosting CAR T-cell responses in lymphoma by simultaneous targeting of CD40/4-1BB using oncolytic viral gene therapy
- 2021
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In: Cancer Immunology and Immunotherapy. - : Springer Nature. - 0340-7004 .- 1432-0851. ; 70:10, s. 2851-2865
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Journal article (peer-reviewed)abstract
- Pretreatment of B-cell lymphoma patients with immunostimulatory gene therapy using armed oncolytic viruses may prime tumor lesions for subsequent chimeric antigen receptor (CAR) T-cell therapy, thereby enhancing CAR T-cell functionality and possibly increasing response rates in patients. LOAd703 (delolimogene mupadenorepvec) is an oncolytic adenovirus (serotype 5/35) that encodes for the transgenes CD40L and 4-1BBL, which activate both antigen-presenting cells and T cells. Many adenoviruses failed to demonstrate efficacy in B-cell malignancies, but LOAd703 infect cells via CD46, which enables B cell infection. Herein, we investigated the therapeutic potential of LOAd703 in human B-cell lymphoma models, alone or in combination with CAR T-cell therapy. LOAd703 could infect and replicate in B-cell lymphoma cell lines (BC-3, Karpas422, Daudi, DG-75, U-698) and induced an overall enhanced immunogenic profile with upregulation of co-stimulatory molecules CD80, CD86, CD70, MHC molecules, death receptor Fas and adhesion molecule ICAM-1. Further, CAR T-cell functionality was boosted by stimulation with lymphoma cells infected with LOAd703. This was demonstrated by an augmented release of IFN-γ and granzyme B, increased expression of the degranulation marker CD107a, fewer PD-1 + TIM-3+ CAR T cells in vitro and enhanced lymphoma cell killing both in in vitro and in vivo xenograft models. In addition, LOAd703-infected lymphoma cells upregulated the secretion of several chemokines (CXCL10, CCL17, CCL22, CCL3, CCL4) essential for immune cell homing, leading to enhanced CAR T-cell migration. In conclusion, immunostimulatory LOAd703 therapy is an intriguing approach to induce anti-lymphoma immune responses and to improve CAR T-cell therapy in B-cell lymphoma.
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| 10. |
- Wentrup, Robert, et al.
(author)
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Digital oases and digital deserts in Sub-Saharan Africa
- 2016
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In: Journal of Science & Technology Policy Management. - 2053-4620. ; 7:1, s. 77-100
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Journal article (peer-reviewed)abstract
- Purpose – This paper aims to investigate whether Sub-Saharan African countries are catching up with the rest of the world in terms of online usage. Online service usage is an important component of the discourse of the “digital divide”, an emblematic term for the inequality of information and communication technology access. Design/methodology/approach – This paper is a quantitative analysis of internet and Facebook penetration coupled with economic strength (GDP/capita), literacy and degree of rural population. Findings – The findings reveal a heterogeneous pattern with a few African countries being digital oases and close to European levels, whereas the majority of the countries are still digital deserts. A strong correlation is found between economic strength and internet penetration. A generalist picture that Sub-Saharan is on the trajectory of closing the digital divide is an imprecise reflection of the reality. Research limitations/implications – It is argued that instead of measuring supply-side data, which has been the trend till now, the use of demand-side elements such as online service usage tells more about digital inequalities between countries. Practical implications – The research encourages internet firms to open up their eyes for Sub-Saharan Africa as an investment opportunity with an untapped gap of online usage. Social implications – The three-billion internet users on the planet are unevenly spread and under-represented in Africa. By drawing a heterogeneous online usage landscape, digital policy can be accurately steered toward countries with the largest needs. Originality/value – There is a paucity of research going into the depth of online usage in Africa. The paper is a contribution to fill that gap.
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