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40 år av genusforskning! : Festskrift till Centrum för genusvetenskap
- 2023
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Samlingsverk (redaktörskap) (övrigt vetenskapligt/konstnärligt)abstract
- Med denna Festskrift firar vi att Centrum för genusvetenskap i över fyrtio år har fungerat som en viktig mötesplats för kunskap och vetenskapande – en sådan plats som många uppfattar som absolut nödvändig för sin överlevnad i akademin. Genom att sätta genus i centrum på Centrum skapar vi kunskap över gränser mellan vetenskapsområden, fakulteter och forskningsfält.Centrum består i grund och botten av de människor som verkar där. Den här Festskriften är också en hyllning till alla dessa människor – deras arbete, engagemang, intelligens, uthållighet och inspirationsförmåga. Centrum existerar också tack vare de viktiga nationella och internationella nätverk inom forskning och utbildning som Centrum är del av. Med denna bok skickar vi alltså en hälsning och ett tack till alla våra kollegor inom fältet. Kapitlen i denna volym är en blandning som sträcker sig från essäer och personliga historieskrivningar om Centrum, till reflektioner om arbetslivet vid Centrum eller som genusforskare överlag, till forskningsartiklar om en rad mycket olika områden, vilka i sig också vittnar om den livliga och variationsrika forskningsmiljö som vi fortsätter att bygga tillsammans.
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5-HT1A targeting PARCEST agent DO3AM-MPP with potential for receptor imaging : Synthesis, physico-chemical and MR studies
- 2021
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Ingår i: Bioorganic chemistry. - : Elsevier. - 0045-2068. ; 106
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Tidskriftsartikel (refereegranskat)abstract
- Contrast enhancement in MRI using magnetization or saturation transfer techniques promises better sensitivity, and faster acquisition compared to T-1 or T-2 contrast. This work reports the synthesis and evaluation of 5-HT1A targeted PARACEST MRI contrast agent using 1,4,7,10-tetraazacycloDOdecane-4,7,10-triacetAMide (DO3AM) as the bifunctional chelator, and 5-HT1A-antagonist methoxyphenyl piperazine (MPP) as a targeting unit. The multistep synthesis led to the MPP conjugated DO3AM with 60% yield. CEST-related physicochemical parameters were evaluated after loading DO3AM-MPP with paramagnetic MRI active lanthanides: Gadolinium (Gd-DO3AM-MPP) and Europium (Eu-DO3AM-MPP). Luminescence lifetime measurements with Eu-DO3AM-MPP and computational DFT studies using Gd-DO3AM-MPP revealed the coordination of one water molecule (q = 1.43) with metal-water distance (r(M)-H2O) of 2.7 angstrom and water residence time (tau(m)) of 0.23 ms. The dissociation constant of K-d 62 +/- 0.02 pM as evaluated from fluorescence quenching of 5-HT1A (protein) and docking score of -4.81 in theoretical evaluation reflect the binding potential of the complex Gd-DO3AM-MPP with the receptor 5-HT1A. Insights of the docked pose reflect the importance of NH2 (amide) and aromatic ring in Gd-DO3AM-MPP while interacting with Ser 374 and Phe 370 in the antagonist binding pocket of 5-HT1A. Gd-DO3AM-MPP shows longitudinal relaxivity 5.85 mM(-1)s(-1) with a water residence lifetime of 0.93 ms in hippocampal homogenate containing 5-HT1A. The potentiometric titration of DO3AM-MPP showed strong selectivity for Gd3+ over physiological metal ions such as Zn2+ and Cu2+. The in vitro and in vivo studies confirmed the minimal cytotoxicity and presential binding of Gd-DO3AM-MPP with 5-HT1A receptor in the hippocampus region of the mice. Summarizing, the complex Gd-DO3AM-MPP can have a potential for CEST imaging of 5-HT1A receptors.
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A Beginner's Guide to Swedish Academia
- 2022
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Samlingsverk (redaktörskap) (övrigt vetenskapligt/konstnärligt)abstract
- As new to the Swedish research system, one is faced with a series of questions, about what applies to qualifications, what the networks look like, but also practical issues. To make things easier, YAS has developed a guide for international researchers, to help navigate Swedish academia and remove time-consuming obstacles.
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A Constructive Critique of Religion. : Encounters between Christianity, Islam, and Non-religion in Secular Societies
- 2020. - 1
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Samlingsverk (redaktörskap) (refereegranskat)abstract
- Why do some strategies for critique of religion seem to be more beneficial for constructive engagement, whereas others increase intolerance, polarization, and conflict?Through an analysis of the reasons underpinning a critique of religion in institutional contexts of secular democratic societies, A Constructive Critique of Religion explores how constructive interaction and critique can be developed across diverse interests. It shows how social and cultural conditions shaping these institutions enable and structure a critical and constructive engagement across diverging worldviews.A key argument running through the book is that to develop constructive forms of critique a more thorough and systematic investigation of resources for criticism located within religious worldviews themselves is needed. Chapters also address how critique of Islam and Christianity in particular is expressed in areas such as academia, the law, politics, media, education and parenting, with a focus on Northern Europe and North America. The interdisciplinary approach, which combines theoretical perspectives with empirical case studies, contributes to advancing studies of the complex and contentious character of religion in contemporary society.
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A History of the Surrealist Novel
- 2023. - 1
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Samlingsverk (redaktörskap) (refereegranskat)abstract
- A History of the Surrealist Novel offers a rich, long, and elastic historiography of the surrealist novel, taking into consideration an abundance of texts previously left out of critical accounts. Its twenty thematically organized chapters examine surrealist prose texts written in French, English, Spanish, German, Greek, and Japanese, from the emergence of the surrealist movement in the 1920s and 1930s, through the post-war and postmodern periods, and up to the contemporary moment. This approach extends received narratives regarding surrealism's geographical locations and considers its transnational movement and modes of circulation. Moreover, it challenges critical biases that have defined surrealism in predominantly masculine terms, and which tie the movement to the interwar or early post-war years. This book will appeal both to scholars and students of surrealism and its legacies, modernist literature, and the history of the novel.
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A Slip of the Machinic Tongue
- 2022
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Konstnärligt arbete (refereegranskat)abstract
- The title of the book, The Computer as Seen at the End of the Human Age, is a reference to the exhibition “The Machine as Seen at the End of the Mechanical Age”, curated by Pontus Hultén for MoMA in 1968, highlighting how technology was influencing art at a time when mechanical machines were increasingly replaced by electronic and chemical devices. Through its selection of contemporary art works the exhibition thus came to function as a recording of technological history.I never got to see the exhibition since I wasn’t born at the time, but a couple of years ago I came across a curious book with a tin cover. The book was published in connection to the exhibition, and the history recorded between its covers ends at approximately the same time that early computers start to make their way into the art world. In the fifty years that followed, art came to be marked by a digital presence. It was that book, along with an interest in dead media, and a curiosity for art aided by algorithms, that sparked the idea for The Computer as Seen at the End of the Human Age.Here you will encounter new works by a selection of artists, specifically invited to use algorithms/AI to contribute to a continuous, self-reproducing, anachronistic, machine aided recording of history. A way to preserve, revise and/or comment upon digital history from the vantage point of present-day technology or through the lens of imagined future media, perspectives and technologies.The works have been created specifically for the book. Some are based on works by other artists, made in another era, repurposed for our time and technologies. Others are based on redundant technologies, revived and given new functions. Some adopt a critical or political approach to the algorithm and its impact on society. Several utilize it as an opportunity to create unique works for each separate copy of the edition. Thousands of files eventually compiled into 200 unique books, each with a different cover and different contents – generated, aided or influenced by algorithms. Participating artists: Geraldine Juárez, Cornelia Sollfrank/Winnie Soon, Mishka Henner, Shane Hope, !Mediengruppe Bitnik, Rosa Menkman, Rosemary Lee, Olle Essvik, Evan Roth, Jonas Lund, Darsha Hewitt, Carl-Johan Rosén, Linda Hilfling Ritasdatter and Jacek Smolicki.Editor: Olle Essvik
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A Slip of the Machinic Tongue : Performative Soundscape Installation
- 2022
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Konstnärligt arbete (refereegranskat)abstract
- The performance was premiered at 'Digital Existence III: Living with Automation' an international conference at Sigtuna Foundation in Sweden, organized by BioMe project led by prof. Amanda Lagerkvist at Uppsala University and featuring Joanna Zylinska, Katherine Hayles, Nick Couldry, Sarah Pink and others. The performance is based on an essay written for a book 'The Computer as Seen at the End of the Human Age', edited by Olle Essvik (Rojal Förlag, Göteborg 2022). A dialog between several repurposed 'smart' speakers is accompanied by a spontaneously evolving soundscape generated by those devices' electromagnetic fields and micro-currents that make them operational. The piece is a component of an artistic inquiry into other, imperceptible voices and sonic realms that underlie and sustain contemporary technologies of voice recognition, synthesis and biometric capture. The project is part of BioMe: Existential Challenges and Ethical Imperatives of Bio-metric AI in Everyday Lifeworlds led by professor Amanda Lagerkvist at the Informatics and Media Department of Uppsala University.
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A Warm Scent of Books : Private Libraries at Leufstabruk and Beyond
- 2023
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Samlingsverk (redaktörskap) (övrigt vetenskapligt/konstnärligt)abstract
- In the eighteenth century, the entomologist and industrialist Charles de Geer (1720–1778), who spent his formative years in the Netherlands, established a library in his manor at Leufstabruk. Since 1986 this library has been owned by Uppsala University Library. This volume contains essays on different aspects of this historical book collection, as well as of similar country house libraries in Sweden and abroad. It is the result of an international symposium held in Leufstabruk and Uppsala in June 2022.
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| 10. |
- Aad, G., et al.
(författare)
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A search for heavy Higgs bosons decaying into vector bosons in same-sign two-lepton final states in pp collisions at √s=13 TeV with the ATLAS detector
- 2023
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Ingår i: Journal of High Energy Physics (JHEP). - : Springer Nature. - 1126-6708 .- 1029-8479. ; 2023:7
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Tidskriftsartikel (refereegranskat)abstract
- A search for heavy Higgs bosons produced in association with a vector boson and decaying into a pair of vector bosons is performed in final states with two leptons (electrons or muons) of the same electric charge, missing transverse momentum and jets. A data sample of proton–proton collisions at a centre-of-mass energy of 13 TeV recorded with the ATLAS detector at the Large Hadron Collider between 2015 and 2018 is used. The data correspond to a total integrated luminosity of 139 fb−1. The observed data are in agreement with Standard Model background expectations. The results are interpreted using higher-dimensional operators in an effective field theory. Upper limits on the production cross-section are calculated at 95% confidence level as a function of the heavy Higgs boson’s mass and coupling strengths to vector bosons. Limits are set in the Higgs boson mass range from 300 to 1500 GeV, and depend on the assumed couplings. The highest excluded mass for a heavy Higgs boson with the coupling combinations explored is 900 GeV. Limits on coupling strengths are also provided.
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