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Early thrombolytic ...
Early thrombolytic therapy in suspected acute myocardial infarction : role of the electrocardiogram: results from the TEAHAT Study
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Risenfors, M (författare)
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Zukauskiene, I (författare)
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Albertsson, P (författare)
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visa fler...
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Hartford, M (författare)
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Lomsky, M (författare)
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- Herlitz, Johan (författare)
- [external],Prehospital akutsjukvård
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visa färre...
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(creator_code:org_t)
- Wiley-Blackwell Publishing Ltd. 1991
- 1991
- Engelska.
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Ingår i: Journal of Internal Medicine. - : Wiley-Blackwell Publishing Ltd.. - 0954-6820 .- 1365-2796. ; 734:suppl 1, s. 19-25
- Relaterad länk:
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https://urn.kb.se/re...
Abstract
Ämnesord
Stäng
- In a placebo-controlled trial in which rt-PA was administered to patients within 2 h and 45 min after the onset of symptoms indicative of acute myocardial infarction (AMI), 352 patients were randomized. Standard 12-lead electrocardiograms (ECGs) were recorded at inclusion and repeatedly during admission and at follow-up after 1 month and 1 year. In patients who presented with ST-segment elevation, the infarction rate was high (88%), whereas in patients without ST-elevation the infarction rate was low (21%), and infarct size, as assessed by serum enzyme activities, was small in this group. There were only minor differences between rt-PA- and placebo-treated patients with regard to ST-segment changes and Q-wave development, whereas the R-wave amplitude was higher after 1 month in patients who were given rt-PA. The infarction rate was not altered by rt-PA, but there was a shift towards a reduction in Q-wave infarction in patients who were treated with rt-PA. When a score system, as suggested by Palmeri et al., intended to reflect the ultimate infarct size, was applied, a significantly lower score was found in infarction patients who were treated with rt-PA as compared to placebo (3.95 +/- 0.35 vs. 2.95 +/- 0.29, P = 0.03), indicating limitation of infarct size. In summary, early treatment with rt-PA resulted in less frequent Q-wave infarction and a reduction in the electrocardiographically estimated infarct size.
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