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The Impact of Graft...
The Impact of Graft-versus-Host Disease on the Relapse Rate in Patients with Lymphoma Depends on the Histological Subtype and the Intensity of the Conditioning Regimen
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- Urbano-Ispizua, Alvaro (författare)
- Univ Barcelona, Hosp Clin, IDIBAPS, Dept Hematol, Barcelona, Spain.;Inst Res Josep Carreras, Barcelona, Spain.
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- Pavletic, Steven Z. (författare)
- NCI, Expt Transplantat & Immunol Branch, Ctr Canc Res, Bethesda, MD 20892 USA.
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- Flowers, Mary E. (författare)
- Fred Hutchinson Canc Res Ctr, Div Clin Res, Seattle, WA 98104 USA.
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visa fler...
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- Klein, John P. (författare)
- Med Coll Wisconsin, Dept Med, Ctr Int Blood & Marrow Transplant Res, Milwaukee, WI 53226 USA.;Med Coll Wisconsin, Inst Hlth & Soc, Div Biostat, Milwaukee, WI 53226 USA.
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- Zhang, Mei-Jie (författare)
- Med Coll Wisconsin, Dept Med, Ctr Int Blood & Marrow Transplant Res, Milwaukee, WI 53226 USA.;Med Coll Wisconsin, Inst Hlth & Soc, Div Biostat, Milwaukee, WI 53226 USA.
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- Carreras, Jeanette (författare)
- Med Coll Wisconsin, Dept Med, Ctr Int Blood & Marrow Transplant Res, Milwaukee, WI 53226 USA.
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- Montoto, Silvia (författare)
- Barts Hlth NHS Trust, St Bartholomews Hosp, Dept Haematooncol, London, England.
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- Perales, Miguel-Angel (författare)
- Mem Sloan Kettering Canc Ctr, Dept Med, Bone Marrow Transplant Serv, New York, NY 10021 USA.
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- Aljurf, Mahmoud D. (författare)
- King Faisal Specialist Hosp Ctr & Res, Dept Oncol, Riyadh, Saudi Arabia.
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- Akpek, Goerguen (författare)
- Banner MD Anderson Canc Ctr, Hematol Oncol Sect, Gilbert, AZ USA.
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- Bredeson, Christopher N. (författare)
- Ottawa Hosp, Blood & Marrow Transplant Program, Ottawa, ON, Canada.;Ottawa Hosp, Res Inst, Ottawa, ON, Canada.
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- Costa, Luciano J. (författare)
- Univ Alabama Birmingham, Dept Med, Div Hematol Oncol, Birmingham, AL 35294 USA.
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- Dandoy, Christopher (författare)
- Cincinnati Childrens Hosp Med Ctr, Cincinnati, OH 45229 USA.
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- Freytes, Cesar O. (författare)
- South Texas Vet Hlth Care Syst, San Antonio, TX USA.;Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA.
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- Fung, Henry C. (författare)
- Temple Hlth, Fox Chase Canc Ctr, Dept Med Oncol, Philadelphia, PA USA.
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- Gale, Robert Peter (författare)
- Univ London Imperial Coll Sci Technol & Med, Dept Med, Div Expt Med, Hematol Res Ctr, London, England.
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- Gibson, John (författare)
- Royal Prince Alfred Hosp, Inst Haematol, Camperdown, NSW 2050, Australia.
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- Hamadani, Mehdi (författare)
- Med Coll Wisconsin, Dept Med, Ctr Int Blood & Marrow Transplant Res, Milwaukee, WI 53226 USA.
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- Hayashi, Robert J. (författare)
- Washington Univ, Sch Med, Dept Pediat, Div Pediat Hematol Oncol, St Louis, MO 63110 USA.
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- Inamoto, Yoshihiro (författare)
- Fred Hutchinson Canc Res Ctr, Div Clin Res, Seattle, WA 98104 USA.
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- Inwards, David J. (författare)
- Mayo Clin, Div Hematol, Rochester, MN USA.
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- Lazarus, Hillard M. (författare)
- Univ Hosp Case Med Ctr, Seidman Canc Ctr, Cleveland, OH USA.
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- Maloney, David G. (författare)
- Fred Hutchinson Canc Res Ctr, Div Clin Res, Seattle, WA 98104 USA.
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- Martino, Rodrigo (författare)
- Hosp Santa Creu & Sant Pau, Div Hematol, Barcelona, Spain.
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- Munker, Reinhold (författare)
- Louisiana State Univ Hlth, Dept Internal Med, Div Hematol Oncol, Shreveport, LA USA.
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- Nishihori, Taiga (författare)
- Univ S Florida, Coll Med, H Lee Moffitt Canc Ctr & Res Inst, Dept Med Oncol, Tampa, FL 33612 USA.
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- Olsson, Richard F. (författare)
- Karolinska Institutet,Uppsala universitet,Centrum för klinisk forskning i Sörmland (CKFD),Karolinska Inst, Dept Lab Med, Div Therapeut Immunol, Stockholm, Sweden.
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- Rizzieri, David A. (författare)
- Duke Univ, Div Hematol Malignancies & Cellular Therapy, Durham, NC USA.
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- Reshef, Ran (författare)
- Univ Penn, Dept Med, Abramson Canc Ctr, Med Ctr, Philadelphia, PA 19104 USA.
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- Saad, Ayman (författare)
- Univ Alabama Birmingham, Dept Med, Div Hematol Oncol, Birmingham, AL 35294 USA.
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- Savani, Bipin N. (författare)
- Vanderbilt Univ, Med Ctr, Dept Med, Div Hematol Oncol, Nashville, TN USA.
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- Schouten, Harry C. (författare)
- Acad Ziekenhuis, Dept Hematol, Maastricht, Netherlands.
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- Smith, Sonali M. (författare)
- Univ Chicago, Hematol Oncol Sect, Chicago, IL 60637 USA.
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- Socie, Gerard (författare)
- Hop St Louis, Dept Hematol, Paris, France.
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- Wirk, Baldeep (författare)
- SUNY Stony Brook, Med Ctr, Dept Internal Med, Stony Brook, NY 11794 USA.
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- Yu, Lolie C. (författare)
- Louisiana State Univ, Med Ctr, Childrens Hosp, Div Hematol Oncol,Ctr Canc & Blood Disorders, New Orleans, LA USA.
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- Saber, Wael (författare)
- Med Coll Wisconsin, Dept Med, Ctr Int Blood & Marrow Transplant Res, Milwaukee, WI 53226 USA.
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Univ Barcelona, Hosp Clin, IDIBAPS, Dept Hematol, Barcelona, Spain;Inst Res Josep Carreras, Barcelona, Spain. NCI, Expt Transplantat & Immunol Branch, Ctr Canc Res, Bethesda, MD 20892 USA. (creator_code:org_t)
- Elsevier BV, 2015
- 2015
- Engelska.
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Ingår i: Biology of blood and marrow transplantation. - : Elsevier BV. - 1083-8791 .- 1523-6536. ; 21:10, s. 1746-1753
- Relaterad länk:
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http://www.bbmt.org/...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- The purpose of this study was to analyze the impact of graft-versus-host disease (GVHD) on the relapse rate of different lymphoma subtypes after allogeneic hematopoietic cell transplantation (allo-HCT). Adult patients with a diagnosis of Hodgkin lymphoma, diffuse large B cell lymphoma, follicular lymphoma (FL), peripheral T cell lymphoma, or mantle cell lymphoma (MCL) undergoing HLA-identical sibling or unrelated donor hematopoietic cell transplantation between 1997 and 2009 were included. Two thousand six hundred eleven cases were included. A reduced-intensity conditioning (RIC) regimen was used in 62.8% of the transplantations. In a multivariate analysis of myeloablative cases (n = 970), neither acute (aGVHD) nor chronic GVHD (cGVHD) were significantly associated with a lower incidence of relapse/progression in any lymphoma subtype. In contrast, the analysis of RIC cases (n = 1641) showed that cGVHD was associated with a lower incidence of relapse/progression in FL (risk ratio [RR],.51; P = 3.049) and in MCL (RR,.41; P = .019). Patients with FL or MCL developing both aGVHD and cGVHD had the lowest risk of relapse (RR,.14; P = .007; and RR,.15; P = .0019, respectively). Of interest, the effect of GVHD on decreasing relapse was similar in patients with sensitive disease and chemoresistant disease. Unfortunately, both aGVHD and cGVHD had a deleterious effect on treatment-related mortality and overall survival (OS) in FL cases but did not affect treatment-related mortality, OS or PFS in MCL. This study reinforces the use of RIC allo-HCT as a platform for immunotherapy in FL and MCL patients.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Nyckelord
- Graft-versus-host disease
- Lymphoma
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Urbano-Ispizua, ...
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Pavletic, Steven ...
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Flowers, Mary E.
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Klein, John P.
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Zhang, Mei-Jie
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Carreras, Jeanet ...
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visa fler...
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Montoto, Silvia
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Perales, Miguel- ...
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Aljurf, Mahmoud ...
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Akpek, Goerguen
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Bredeson, Christ ...
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Costa, Luciano J ...
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Dandoy, Christop ...
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Freytes, Cesar O ...
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Fung, Henry C.
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Gale, Robert Pet ...
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Gibson, John
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Hamadani, Mehdi
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Hayashi, Robert ...
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Inamoto, Yoshihi ...
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Inwards, David J ...
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Lazarus, Hillard ...
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Maloney, David G ...
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Martino, Rodrigo
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Munker, Reinhold
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Nishihori, Taiga
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Olsson, Richard ...
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Rizzieri, David ...
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Reshef, Ran
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Saad, Ayman
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Savani, Bipin N.
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Schouten, Harry ...
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Smith, Sonali M.
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Socie, Gerard
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Wirk, Baldeep
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Yu, Lolie C.
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Saber, Wael
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