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- Andreasson, Håkan, 1966
(författare)
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Black Hole Formation from a Complete Regular Past for Collisionless Matter
- 2012
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Ingår i: Annales Henri Poincaré. - : Springer Science and Business Media LLC. - 1424-0637 .- 1424-0661. ; 13:7, s. 1511-1536
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Tidskriftsartikel (refereegranskat)abstract
- Initial data for the spherically symmetric Einstein-Vlasov system is constructed whose past evolution is regular and whose future evolution contains a black hole. This is the first example of initial data with these properties for the Einstein-matter system with a "realistic" matter model. One consequence of the result is that there exists a class of initial data for which the ratio of the Hawking mass mIS= mIS (r) and the area radius r is arbitrarily small everywhere, such that a black hole forms in the evolution. This result is in a sense analogous to the result (Christodoulou Commun Pure Appl Math 44:339-373, 1991) for a scalar field. Another consequence is that there exist black hole initial data such that the solutions exist for all Schwarzschild time .
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| 2. |
- Andreasson, Håkan, 1966, et al.
(författare)
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Bounds on M/R for charged objects with positive cosmological constant
- 2012
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Ingår i: Classical and Quantum Gravity. - : IOP Publishing. - 0264-9381 .- 1361-6382. ; 29:9
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Tidskriftsartikel (refereegranskat)abstract
- We consider charged spherically symmetric static solutions of the Einstein-Maxwell equations with a positive cosmological constant Lambda. If r denotes the area radius, m(g) and q the gravitational mass and charge of a sphere with area radius r respectively, we find that for any solution which satisfies the condition p + 2p(perpendicular to) +/- <= rho, where p >= 0 and p(perpendicular to) are the radial and tangential pressures respectively, rho >= 0 is the energy density, and for which 0 <= q(2)/r(2) + Lambda r(2) <= 1, the inequality m(g)/r <= 2/9 + q(2)/3r(2)-Lambda r(2)/3 + 2/9 root 1 + 3q(2)/r(2) + 3 Lambda r(2) holds. We also investigate the issue of sharpness, and we showthat the inequality is sharp in a few cases but generally this question is open.
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| 3. |
- Andreasson, Håkan, et al.
(författare)
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Histopathological classification of pseudomyxoma peritonei and the prognostic importance of PINCH protein
- 2012
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Ingår i: Anticancer Research. - : International Institute of Anticancer Research (IIAR). - 0250-7005 .- 1791-7530. ; 32:4, s. 1443-1448
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Tidskriftsartikel (refereegranskat)abstract
- AIM: The aims of this study were i) to assess a new and more detailed histopathological classification and to analyze concordance between pathologists in the histopathological classification of pseudomyxoma peritonei (PMP); ii) to analyze the expression in the stroma of the particularly interesting new cysteine-histidine (PINCH) protein and its prognostic importance in PMP.MATERIALS AND METHODS: Surgical specimens from 81 patients, classified according to the Ronnett et al histopathological classification were compared to a new system with four groups ranging from indolent to aggressive growth patterns. PINCH protein expression was analyzed and was related to clinical variables.RESULTS: The new four-group classification provided better prognostic information than the classification according to Ronnett et al. (p=0.04). Expression of the PINCH protein in the stroma was found in 83% of the cases and was associated with high tumor burden (p=0.002) and a poor prognosis (p=0.04).CONCLUSION: The proposed new PMP classification system may provide additional prognostic information. PINCH protein is expressed in PMP and has prognostic information.
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| 4. |
- Andréasson, Håkan, et al.
(författare)
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Outcome differences between debulking surgery and cytoreductive surgery in patients with pseudomyxoma peritonei
- 2012
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Ingår i: European Journal of Surgical Oncology. - : Elsevier BV. - 0748-7983 .- 1532-2157. ; 38:10, s. 962-968
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND:The aim of this study was to compare debulking surgery and cytoreductive surgery (CRS) in patients with Pseudomyxoma peritonei (PMP) regarding efficacy and safety.PATIENTS AND METHODS:Data were extracted from medical records and treatment outcomes were analyzed for all 152 patients with PMP who were scheduled for debulking surgery and intraperitoneal chemotherapy (IPC) or CRS and IPC at Uppsala University Hospital, Uppsala, Sweden, between September 1993 and December 2008.RESULTS:One hundred and ten patients (73%) were treated with CRS and IPC and 40 (27%) with debulking surgery and IPC. In two patients (1%), surgery was defined as open and close. Patients with CRS and IPC had a 74% 5-year overall survival (OS) rate compared with 40% for those treated with debulking surgery (P < 0.001). Patients with no residual macroscopic tumour (R1 resection) had a better 5-year OS rate of 94% compared with 28% for patients with macroscopic residual tumour (R2) (P < 0.001). Grades II-IV adverse events were seen in 29% of debulked patients and in 47% of CRS/IPC patients (P = 0.053).CONCLUSIONS:CRS and IPC seems more efficient than debulking surgery and IPC but with numerically higher morbidity. Therefore, if surgically possible, CRS should be the treatment of choice for PMP patients. However, debulking surgery may still be of benefit to selected patients for palliative purposes.
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