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- Scelo, Ghislaine, et al.
(författare)
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Exploring Definitions and Predictors of Response to Biologics for Severe Asthma
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Ingår i: Journal of Allergy and Clinical Immunology: In Practice. - 2213-2198.
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Tidskriftsartikel (refereegranskat)abstract
- Background: Biologic effectiveness is often assessed as response, a term that eludes consistent definition. Identifying those most likely to respond in real-life has proven challenging. Objective: To explore definitions of biologic responders in adults with severe asthma and investigate patient characteristics associated with biologic response. Methods: This was a longitudinal cohort study using data from 21 countries, which shared data with the International Severe Asthma Registry. Changes in four asthma outcome domains were assessed in the 1-year period before and after biologic initiation in patients with a predefined level of prebiologic impairment. Responder cutoffs were 50% or greater reduction in exacerbation rate, 50% or greater reduction in long-term oral corticosteroid daily dose, improvement in one or more category in asthma control, and 100 mL or greater improvement in FEV1. Responders were defined using single and multiple domains. The association between prebiologic characteristics and postbiologic initiation response was examined by multivariable analysis. Results: A total of 2,210 patients were included. Responder rate ranged from 80.7% (n = 566 of 701) for exacerbation response to 10.6% (n = 9 of 85) for a four-domain response. Many responders still exhibited significant impairment after biologic initiation: 46.7% (n = 206 of 441) of asthma control responders with uncontrolled asthma before the biologic still had incompletely controlled disease postbiologic initiation. Predictors of response were outcome-dependent. Lung function responders were more likely to have higher prebiologic FeNO (odds ratio = 1.20 for every 25-parts per billion increase), and shorter asthma duration (odds ratio = 0.81 for every 10-year increase in duration). Higher blood eosinophil count and the presence of type 2-related comorbidities were positively associated with higher odds of meeting long-term oral corticosteroid, control, and lung function responder criteria. Conclusions: Our findings underscore the multimodal nature of response, showing that many responders experience residual symptoms after biologic initiation and that predictors of response vary according to the outcome assessed. © 2024 The Authors
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- Algaba Brazalez, Astrid, 1983, et al.
(författare)
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Improving microstrip filters with gap waveguide packaging
- 2011
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Ingår i: Proceedings of the 5th European Conference on Antennas and Propagation, EUCAP 2011. Rome, 11-15 April 2011. - 9781457702501 ; , s. 1080-1084
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Konferensbidrag (refereegranskat)abstract
- A study is presented of the performance of microstrip filters packaged with Perfect Magnetic Conductor (PMC) and realization of the PMC using a lid of nails. A 3rd order parallel coupled-line bandpass filter is designed and packaged with a lid of nails at the Ku-band. The study shows the PMC packaging technique is very efficient in improving the filter characteristics including the insertion loss in the bandpass region.
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- Christophers, Brett, 1971-
(författare)
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Risk capital: : Urban political ecology and entanglements of financial and environmental risk in Washington, D.C.
- 2018
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Ingår i: Environment and Planning E: Nature and Space. - : SAGE Publications. - 2514-8486 .- 2514-8494. ; 1:1-2, s. 144-164
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Tidskriftsartikel (refereegranskat)abstract
- n endeavouring to deal with a longstanding problem of contamination of waterways in Washington, D.C. due to combined sewer overflows, the responsible utility, DC Water, has recently embarked on a two-fold, simultaneous ‘greening’ – firstly of the physical infrastructures being installed to address the overflow problem, and secondly of the financing of this capital investment. This article examines DC Water’s turn to green infrastructure and green bonds in order to consider the question of how environmental and financial processes in general – and environmental and financial risks in particular – co-determine not just one another but the transformation of contemporary urban socioecological landscapes more broadly. In the process, it aims to inject a greater sensibility both to finance and to ‘green capitalism’ into urban political ecology. Through a critical consideration of the interlocking temporal, spatial and monetary dimensions of DC Water’s two-fold greening project, the article shows that this project has served significantly to augment levels of environmental and financial risk, entangling them in significant new ways.
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