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| 2. |
- Abe, O, et al.
(författare)
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Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials
- 2005
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Ingår i: The Lancet. - 1474-547X. ; 365:9472, s. 1687-1717
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Tidskriftsartikel (refereegranskat)abstract
- Background Quinquennial overviews (1985-2000) of the randomised trials in early breast cancer have assessed the 5-year and 10-year effects of various systemic adjuvant therapies on breast cancer recurrence and survival. Here, we report the 10-year and 15-year effects. Methods Collaborative meta-analyses were undertaken of 194 unconfounded randomised trials of adjuvant chemotherapy or hormonal therapy that began by 1995. Many trials involved CMF (cyclophosphamide, methotrexate, fluorouracil), anthracycline-based combinations such as FAC (fluorouracil, doxombicin, cyclophosphamide) or FEC (fluorouracil, epirubicin, cyclophosphamide), tamoxifen, or ovarian suppression: none involved taxanes, trastuzumab, raloxifene, or modem aromatase inhibitors. Findings Allocation to about 6 months of anthracycline-based polychemotherapy (eg, with FAC or FEC) reduces the annual breast cancer death rate by about 38% (SE 5) for women younger than 50 years of age when diagnosed and by about 20% (SE 4) for those of age 50-69 years when diagnosed, largely irrespective of the use of tamoxifen and of oestrogen receptor (ER) status, nodal status, or other tumour characteristics. Such regimens are significantly (2p=0 . 0001 for recurrence, 2p<0 . 00001 for breast cancer mortality) more effective than CMF chemotherapy. Few women of age 70 years or older entered these chemotherapy trials. For ER-positive disease only, allocation to about 5 years of adjuvant tamoxifen reduces the annual breast cancer death rate by 31% (SE 3), largely irrespective of the use of chemotherapy and of age (<50, 50-69, &GE; 70 years), progesterone receptor status, or other tumour characteristics. 5 years is significantly (2p<0 . 00001 for recurrence, 2p=0 . 01 for breast cancer mortality) more effective than just 1-2 years of tamoxifen. For ER-positive tumours, the annual breast cancer mortality rates are similar during years 0-4 and 5-14, as are the proportional reductions in them by 5 years of tamoxifen, so the cumulative reduction in mortality is more than twice as big at 15 years as at 5 years after diagnosis. These results combine six meta-analyses: anthracycline-based versus no chemotherapy (8000 women); CMF-based versus no chemotherapy (14 000); anthracycline-based versus CMF-based chemotherapy (14 000); about 5 years of tamoxifen versus none (15 000); about 1-2 years of tamoxifen versus none (33 000); and about 5 years versus 1-2 years of tamoxifen (18 000). Finally, allocation to ovarian ablation or suppression (8000 women) also significantly reduces breast cancer mortality, but appears to do so only in the absence of other systemic treatments. For middle-aged women with ER-positive disease (the commonest type of breast cancer), the breast cancer mortality rate throughout the next 15 years would be approximately halved by 6 months of anthracycline-based chemotherapy (with a combination such as FAC or FEC) followed by 5 years of adjuvant tamoxifen. For, if mortality reductions of 38% (age <50 years) and 20% (age 50-69 years) from such chemotherapy were followed by a further reduction of 31% from tamoxifen in the risks that remain, the final mortality reductions would be 57% and 45%, respectively (and, the trial results could well have been somewhat stronger if there had been full compliance with the allocated treatments). Overall survival would be comparably improved, since these treatments have relatively small effects on mortality from the aggregate of all other causes. Interpretation Some of the widely practicable adjuvant drug treatments that were being tested in the 1980s, which substantially reduced 5-year recurrence rates (but had somewhat less effect on 5-year mortality rates), also substantially reduce 15-year mortality rates. Further improvements in long-term survival could well be available from newer drugs, or better use of older drugs.
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| 4. |
- Carninci, P, et al.
(författare)
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The transcriptional landscape of the mammalian genome
- 2005
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Ingår i: Science (New York, N.Y.). - : American Association for the Advancement of Science (AAAS). - 1095-9203 .- 0036-8075. ; 309:5740, s. 1559-1563
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Tidskriftsartikel (refereegranskat)abstract
- This study describes comprehensive polling of transcription start and termination sites and analysis of previously unidentified full-length complementary DNAs derived from the mouse genome. We identify the 5′ and 3′ boundaries of 181,047 transcripts with extensive variation in transcripts arising from alternative promoter usage, splicing, and polyadenylation. There are 16,247 new mouse protein-coding transcripts, including 5154 encoding previously unidentified proteins. Genomic mapping of the transcriptome reveals transcriptional forests, with overlapping transcription on both strands, separated by deserts in which few transcripts are observed. The data provide a comprehensive platform for the comparative analysis of mammalian transcriptional regulation in differentiation and development.
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| 5. |
- Abdallah, J, et al.
(författare)
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Bose-Einstein correlations in W+W- events at LEP2
- 2005
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Ingår i: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 44:2, s. 161-174
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Tidskriftsartikel (refereegranskat)abstract
- Bose-Einstein correlations (BEC) between final state particles in the reaction e(+)e(-) -> W+ W- -> q(1)(q(2)) over barq(3)(q(4)over bar>) over bar) have been studied. Data corresponding to a total integrated luminosity of 550 pb(-1), recorded by the DELPHI detector at centre-of-mass energies ranging from 189 to 209 GeV, were analysed. An indication for inter-W BEC between like-sign particles has been found at the level of 2.4 standard deviations of the combined statistical and systematic uncertainties.
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| 6. |
- Abdallah, J, et al.
(författare)
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Flavour independent searchesfor hadronically decaying neutral Higgs bosons
- 2005
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Ingår i: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 44:2, s. 147-159
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Tidskriftsartikel (refereegranskat)abstract
- This paper describes flavour independent searches for hadronically decaying neutral Higgs bosons in the data collected by the DELPHI experiment at LEP, at centre-of-mass energies between 189 and 209 GeV. The collected data-set corresponds to an integrated luminosity of around 610 pb(-1). The e(+)e(-) -> hA and e(+)e(-) -> hZand processes are considered, with direct Higgs boson decays into hadrons. No evidence for Higgs boson production is found, and cross-section limits are set as a function of the Higgs boson masses. No explicit assumptions are made on the underlying physics beyond the Standard Model, allowing interpretation of the data in a large class of models.
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| 7. |
- Abdallah, J, et al.
(författare)
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Measurement of the energy dependence of hadronic jet rates and the strong coupling alpha(s) from the four-jet rate with the DELPHI detector at LEP
- 2005
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Ingår i: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 38:4, s. 413-426
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Tidskriftsartikel (refereegranskat)abstract
- Hadronic events from the data collected with the DELPHI detector at LEP within the energy range from 89 GeV to 209 GeV are selected, their jet rates are determined and compared to predictions of four different event generators. One of them is the recently developed APACIC++ generator which performs a massive matrix element calculation matched to a parton shower followed by string fragmentation. The four-jet rate is used to measure alpha(s) in the next-to-leading-order approximation yielding alpha(s)(M-Z(2)) = 0.1175 +/- 0.0030. The running of alpha(s) determined by using four-jet events has been tested. The logarithmic energy slope is measured to be dalpha(s)(-1)/d log E-cm = 1.14 +/- 0.36. Since the analysis is based on four-jet final states it represents an alternative approach to previous DELPHI alpha(s) measurements using event shape distributions.
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| 8. |
- Abdallah, J, et al.
(författare)
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Photon events with missing energy in e(+)e(-) collisions at root s=130 to 209 GeV
- 2005
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Ingår i: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 38:4, s. 395-411
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Tidskriftsartikel (refereegranskat)abstract
- The production of single- and multi-photon events has been studied in the reaction e(+) e(-) --> gamma(gamma) + invisible particles. The data collected with the DELPHI detector during the years 1999 and 2000 at centre-of-mass energies between 191 GeV and 209 GeV was combined with earlier data to search for phenomena beyond the Standard Model. The measured number of light neutrino families was consistent with three and the absence of an excess of events beyond that predicted by the Standard Model processes was used to set limits on new physics. Both model-independent searches and searches for new processes predicted by supersymmetric and extra-dimensional models have been made. Limits on new non-standard model interactions between neutrinos and electrons were also determined.
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| 9. |
- Abdallah, J, et al.
(författare)
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Charged particle multiplicity in three-jet events and two-gluon systems
- 2005
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Ingår i: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; C:44, s. 311-331
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Tidskriftsartikel (refereegranskat)abstract
- The charged particle multiplicity in hadronic three-jet events from Z decays is investigated. The topology dependence of the event multiplicity is found to be well described by a modified leading logarithmic prediction. A parameter fit of the prediction to the data yields a measurement of the colour factor ratio C-A/C-F with the result C-A/C-F = 2.261 +/- 0.014(stat). +/- 0.036(exp). +/- 0-066(theo). in agreement with the SU(3) expectation of QCD. The quark-related contribution to the event multiplicity is subtracted from the three-jet event multiplicity resulting in a measurement of the multiplicity of two-gluon colour-singlet states over a wide energy range. The ratios r = N-gg(s)/Ng (g) over bar (s) of the gluon and quark multiplicities and r((1)) = N'(gg)(s)/N'g (g) over bar (s) of their derivatives are compared with perturbative calculations. While a good agreement between calculations and data is observed for r((1)), larger deviations are found for r indicating that non-perturbative effects are more important for r than for r((1)).
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| 10. |
- Abdallah, J, et al.
(författare)
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Coherent soft particle production in Z decays into three jets
- 2005
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Ingår i: Physics Letters. Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier BV. - 0370-2693. ; 605:1-2, s. 37-48
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Tidskriftsartikel (refereegranskat)abstract
- Low-energy particle production perpendicular to the event plane in three-jet events produced in Z decays in e(+)e(-) annihilation is measured and compared to that perpendicular to the event axis in two-jet events. The topology dependence of the hadron production ratio is found to agree with a leading-order QCD prediction. This agreement and especially the need for the presence of a destructive interference term gives evidence for the coherent nature of gluon radiation. Hadron production in three-jet events is found to be directly proportional to a single topological scale function of the inter-jet angles. The slope of the dependence of the multiplicity with respect to the topological scale was measured to be 2.211 +/- 0.014(stat.) +/- 0.053(syst.) in good agreement with the expectation given by the colour-factor ratio C-A/C-F = 9/4. This result strongly supports the assumption of local parton-hadron duality, LPHD, at low hadron momentum.
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