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Melanin-Concentrati...
Melanin-Concentrating Hormone and Its MCH-1 Receptor: Relationship Between Effects on Alcohol and Caloric Intake
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- Karlsson, Camilla (författare)
- Linköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten
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- Aziz, Abdul Maruf Asif (författare)
- Linköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten
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- Rehman, Faazal (författare)
- NIAAA, MD USA
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- Pitcairn, Caleb (författare)
- Laboratory of Clinical and Translational Studies, NIAAA, NIH, Bethesda, Maryland, USA
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- Barchiesi, Riccardo (författare)
- Linköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten
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- Barbier, Estelle (författare)
- Linköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten
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- Wendel Hansen, Mikaela (författare)
- Linköpings universitet,Institutionen för klinisk och experimentell medicin,Medicinska fakulteten
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- Gehlert, Don (författare)
- CNS Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana, USA
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- Steensland, Pia (författare)
- Karolinska Institutet,Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
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- Heilig, Markus (författare)
- Linköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten,Centrum för social och affektiv neurovetenskap (CSAN),Region Östergötland, Psykiatriska kliniken
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- Thorsell, Annika (författare)
- Linköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten
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(creator_code:org_t)
- 2016-08-31
- 2016
- Engelska.
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Ingår i: Alcoholism. - : Wiley-Blackwell. - 0145-6008 .- 1530-0277. ; 40:10, s. 2199-2207
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Background: Reward and energy homeostasis are both regulated by a network of hypothalamic neuropeptide systems. The melanin-concentrating hormone (MCH) and its MCH-1 receptor (MCH1-R) modulate alcohol intake, but it remains unknown to what extent this reflects actions on energy balance or reward. Here, we evaluated the MCH1-R in regulation of caloric intake and motivation to consume alcohol in states of escalated consumption.Methods: Rats had intermittent access (IA) to alcohol and were divided into high- and low-drinking groups. Food and alcohol consumption was assessed after administration of an MCH1-R antagonist, GW803430. Next, GW803430 was evaluated on alcohol self-administration in protracted abstinence induced by IA in high-drinking rats. Finally, the effect of GW803430 was assessed on alcohol self-administration in acute withdrawal in rats exposed to alcohol vapor. Gene expression of MCH and MCH1-R was measured in the hypothalamus and nucleus accumbens (NAc) in both acute and protracted abstinence.Results: High-drinking IA rats consumed more calories from alcohol than chow and GW803430 decreased both chow and alcohol intake. In low-drinking rats, only food intake was affected. In protracted abstinence from IA, alcohol self-administration was significantly reduced by pretreatment with GW803430 and gene expression of both MCH and the MCH1-R were dysregulated in hypothalamus and NAc. In contrast, during acute withdrawal from vapor exposure, treatment with GW803430 did not affect alcohol self-administration, and no changes in MCH or MCH1-R gene expression were observed.Conclusions: Our data suggest a dual role of MCH and the MCH1-R in regulation of alcohol intake, possibly through mechanisms involving caloric intake and reward motivation. A selective suppression of alcohol self-administration during protracted abstinence by GW803430 was observed and accompanied by adaptations in gene expression of MCH and MCH1-R. Selective suppression of escalated consumption renders the MCH1-R an attractive target for treatment of alcohol use disorders.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Beroendelära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Substance Abuse (hsv//eng)
Nyckelord
- Alcohol Escalation
- Reward
- Motivation
- Calorie Intake
- Melanin-Concentrating Hormone Receptor-1
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Karlsson, Camill ...
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Aziz, Abdul Maru ...
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Rehman, Faazal
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Pitcairn, Caleb
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Barchiesi, Ricca ...
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Barbier, Estelle
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visa fler...
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Wendel Hansen, M ...
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Gehlert, Don
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Steensland, Pia
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Heilig, Markus
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Thorsell, Annika
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Alcoholism
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Linköpings universitet
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Karolinska Institutet