| 1. |
- Altai, Mohamed, et al.
(författare)
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Affibody-derived drug conjugates : Potent cytotoxic molecules for treatment of HER2 over-expressing tumors
- 2018
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Ingår i: Journal of Controlled Release. - : Elsevier B.V.. - 0168-3659 .- 1873-4995. ; 288, s. 84-95
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Tidskriftsartikel (refereegranskat)abstract
- Patients with HER2-positive tumors often suffer resistance to therapy, warranting development of novel treatment modalities. Affibody molecules are small affinity proteins which can be engineered to bind to desired targets. They have in recent years been found to allow precise targeting of cancer specific molecular signatures such as the HER2 receptor. In this study, we have investigated the potential of an affibody molecule targeting HER2, ZHER2:2891, conjugated with the cytotoxic maytansine derivate MC-DM1, for targeted cancer therapy. ZHER2:2891 was expressed as a monomer (ZHER2:2891), dimer ((ZHER2:2891)2) and dimer with an albumin binding domain (ABD) for half-life extension ((ZHER2:2891)2-ABD). All proteins had a unique C-terminal cysteine that could be used for efficient and site-specific conjugation with MC-DM1. The resulting affibody drug conjugates were potent cytotoxic molecules for human cells over-expressing HER2, with sub-nanomolar IC50-values similar to trastuzumab emtansine, and did not affect cells with low HER2 expression. A biodistribution study of a radiolabeled version of (ZHER2:2891)2-ABD-MC-DM1, showed that it was taken up by the tumor. The major site of off-target uptake was the kidneys and to some extent the liver. (ZHER2:2891)2-ABD-MC-DM1 was found to have a half-life in circulation of 14 h. The compound was tolerated well by mice at 8.5 mg/kg and was shown to extend survival of mice bearing HER2 over-expressing tumors. The findings in this study show that affibody molecules are a promising class of engineered affinity proteins to specifically deliver small molecular drugs to cancer cells and that such conjugates are potential candidates for clinical evaluation on HER2-overexpressing cancers.
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| 2. |
- Baars, Adája E, et al.
(författare)
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Fruit and vegetable consumption and its contribution to inequalities in life expectancy and disability-free life expectancy in ten European countries
- 2019
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Ingår i: International Journal of Public Health. - : Springer. - 1661-8556 .- 1661-8564. ; 64:6, s. 861-872
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVES: To assess to what extent educational differences in total life expectancy (TLE) and disability-free life expectancy (DFLE) could be reduced by improving fruit and vegetable consumption in ten European countries.METHODS: Data from national census or registries with mortality follow-up, EU-SILC, and ESS were used in two scenarios to calculate the impact: the upward levelling scenario (exposure in low educated equals exposure in high educated) and the elimination scenario (no exposure in both groups). Results are estimated for men and women between ages 35 and 79 years.RESULTS: Varying by country, upward levelling reduced inequalities in DFLE by 0.1-1.1 years (1-10%) in males, and by 0.0-1.3 years (0-18%) in females. Eliminating exposure reduced inequalities in DFLE between 0.6 and 1.7 years for males (6-15%), and between 0.1 years and 1.8 years for females (3-20%).CONCLUSIONS: Upward levelling of fruit and vegetable consumption would have a small, positive effect on both TLE and DFLE, and could potentially reduce inequalities in TLE and DFLE.
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| 3. |
- Bogdan, Henrik, 1972
(författare)
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Advaita Vedanta in the Works of Kenneth Grant
- 2018
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Ingår i: Servants of the Star & the Snake: Essays in Honour of Kenneth and Steffi Grant. Edited by Henrik Bogdan. - London : Starfire Publishing. - 9781906073398 ; , s. 39-56
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 4. |
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| 5. |
- Bogdan, Henrik, 1972
(författare)
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Encyclopedia of Religion
- 2017
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Ingår i: Insikt och handling. 25, Lexikon över lexikon / redaktör Bo Hanson. - Lund : Hans Larsson samfundet. - 0436-8096. - 9789163926570 ; , s. 41-43
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 6. |
- Bogdan, Henrik, 1972
(författare)
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Esotericism Practiced: Ritual and Performance
- 2016
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Ingår i: April D. DeConick, ed. "Religion: Secret Religion". Part of the Macmillan Interdisciplinary Handbooks: Religion series. 2016.. - Farmington Hills, MI : Macmillan Reference USA. - 0028663578 ; , s. 249-262
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Bokkapitel (refereegranskat)
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| 7. |
- Bogdan, Henrik, 1972
(författare)
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Evocation of the Fire Snake: Kenneth Grant and Tantra
- 2018
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Ingår i: Servants of the Star & the Snake: Essays in Honour of Kenneth and Steffi Grant. Edited by Henrik Bogdan. - London : Starfire Publishing. - 9781906073398 ; , s. 253-268
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 8. |
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| 9. |
- Bogdan, Henrik, 1972
(författare)
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Fin-de-siècle, ockultism och gnosis
- 2015
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Ingår i: Anywhere out of the World: Olof Sager-Nelson och hans samtida. Red. Johan Sjöström.. - Göteborg : Göteborgs konstmuseum. - 9789187968952 ; , s. 119-127
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 10. |
- Bogdan, Henrik, 1972
(författare)
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Foreword to "Early Poetic Works" by Aleister Crowley.
- 2019
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Ingår i: "Early Poetic Works" by Aleister Crowley (Aceldama: A Place to Bury Strangers In; Jezebel and Other Tragic Poems; Songs of the Spirit; The Tale of Archais: A Romance in Verse). Edited, Annotated and Introduced by Christian Giudice. - London : Kamuret Press. - 9781916091603
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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