| 1. |
- Abdulraheem, Salem, et al.
(författare)
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Hawthorne effect reporting in orthodontic randomized controlled trials : truth or myth? Blessing or curse?
- 2018
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Ingår i: European Journal of Orthodontics. - : Oxford University Press. - 0141-5387 .- 1460-2210. ; 40:5, s. 475-479
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Forskningsöversikt (refereegranskat)abstract
- Objective To investigate in 10 orthodontic journals how many randomized controlled trials (RCTs) considered the Hawthorne effect, and if considered, to determine whether it was related to the patients or the therapists involved in the trial and, finally, to discuss the Hawthorne effect in an educational way. Materials and methods A search was performed on the Medline database, via PubMed, for publication type ‘randomized controlled trial’ published for each journal between 1 August 2007 and 31 July 2017. The American Journal of Orthodontics and Dentofacial Orthopedics, Angle Orthodontist, Australian Orthodontic Journal, Dental Press Journal of Orthodontics, European Journal of Orthodontics, Journal of Orthodontics, Journal of Orofacial Orthopedics, Korean Journal of Orthodontics, Orthodontics and Craniofacial Research and Progress in Orthodontics were assessed. Two independent reviewers extracted the data and identified whether the Hawthorne effect was considered or discussed in the articles and whether the Hawthorne effect was related to the behaviour of the patients, the therapists, or both. Results The initial search generated 502 possible trials. After applying the inclusion and exclusion criteria, 290 RCTs were included and assessed. The Hawthorne effect was considered or discussed in 10 of 290 RCTs (3.4%), and all were related to the patients’ and none to the therapists’ behaviour. Conclusions The Hawthorne effect reported in orthodontic RCTs was suboptimal. The researchers’ lack of knowledge about this phenomenon is evident, despite evidence that the Hawthorne effect may cause over-optimistic results or false-positive bias.
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| 2. |
- Abdulraheem, Salem, et al.
(författare)
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The reporting of blinding in orthodontic randomized controlled trials : where do we stand?
- 2019
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Ingår i: European Journal of Orthodontics. - : Oxford Academic. - 0141-5387 .- 1460-2210. ; 41:1, s. 54-58
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Tidskriftsartikel (refereegranskat)abstract
- Objective: To analyse in 10 orthodontic journals how many randomized controlled trials (RCTs) performed 'single-', 'double-', 'triple-', or 'outcome assessors blinding' and to evaluate, from the number of RCTs that did not conduct blinding, how many could actually have achieved it. Material and methods: Randomized controlled trials published in 10 orthodontic journals between 1 September 2012 and 28 February 2018 were included. A search was performed in PubMed and conducted for publication type 'randomized controlled trial' for each journal. Two reviewers independently analysed each RCT and registered that blinding was performed and included which specific type. It was also evaluated whether misclassifications of blinding items occurred and whether it was possible to achieve blinding among the RCTs that did not perform blinding. Results: After applying the inclusion criteria, 203 RCTs were assessed, and 61.6 per cent of them had used blinding, with the main type being 'outcome assessors blinding' (40.4%) followed by 'single-blinding' (15.3%), 'double-blinding' (2.5%), and 'triple-blinding' (3.4%). In 38.4 per cent of the trials, no blinding was performed; however, 79.4 per cent of them could have achieved blinding. Fifteen RCTs (7.3%) misclassified the blinding in relation to single-, double-, or triple-blinding. Journals followed the CONSORT (AJODO, EJO, JO, OCR) published together significantly more RCTs that performed blinding than journals not following the CONSORT. Conclusions: Blinding of outcome assessors was the most frequent type, as orthodontic trials are often of intervention design and thereby difficult to mask for patients and trial staff. The misclassifications of blinding items may indicate suboptimal knowledge among researchers and peer-reviewers regarding the definitions for diverse blinding types.
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| 3. |
- Abrahamsson, Cecilia, et al.
(författare)
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Masticatory function in patients with dentofacial deformities before and after orthognathic treatment : a prospective, longitudinal, and controlled study
- 2015
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Ingår i: European Journal of Orthodontics. - : Oxford University Press. - 0141-5387 .- 1460-2210. ; 37:1, s. 67-72
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVES: The aim of this study was to investigate the self-estimated masticatory ability and masticatory performance in patients with dentofacial deformities before and after orthognathic treatment; in comparison to an age- and gender-matched control group. SUBJECTS AND METHODS: The masticatory ability and masticatory performance were evaluated in 121 consecutive patients (treatment group), referred for orthognathic treatment. Eighteen months after treatment, 98 patients (81%) completed a follow-up examination. Masticatory ability was assessed on a visual analog scale, while the masticatory performance was evaluated by a masticatory test using round silicon tablets. Signs and symptoms of temporomandibular disorders (TMD) were registered by a clinical examination and a questionnaire. The control group comprised 56 age- and gender-matched subjects who were examined at baseline. RESULTS: At the baseline examination, the treatment group had a significantly lower masticatory ability and performance compared with the control group. After treatment, the masticatory ability significantly improved in the treatment group and reached the same level as in the control group. The masticatory performance index increased significantly but was still lower than in the control group. Both the masticatory ability and masticatory performance were affected by the number of occlusal contacts during maximal biting pressure and by the self-estimated overall symptoms of TMD. CONCLUSIONS: Patients with dentofacial deformities, corrected by orthognathic treatment, have a significant positive treatment outcome in respect of masticatory ability and masticatory performance. Furthermore, the occlusion and symptoms of TMD have an impact on both masticatory ability and masticatory performance.
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| 4. |
- Alexandersson, Gunnar, et al.
(författare)
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Coopetition between commercial and subsidized railway services : The case of the greater Stockholm region
- 2018
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Ingår i: Research in Transportation Economics. - : Elsevier. - 1875-7979 .- 0739-8859. ; 69:SI, s. 349-359
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Tidskriftsartikel (refereegranskat)abstract
- An important ingredient of the Swedish railway system is the increased involvement of public actors in the provision of local and regional railway services. The local and regional railway services show the strongest growth of all market segments in the Swedish passenger railway market. The strong growth is due both to changes in travel patterns and improved subsidized railway services. One important factor in the success of the regional public transport authorities’ (PTA) railway services is the redefinition of the scope of these railway services by interconnecting regional railway networks into bigger entities.In 2017, nearly all local and regional railway services in Sweden's most populated region, Mälardalen, became part of a network of railway services subsidized by the PTAs in the greater region. We analyse the cooperative and competitive interactions between the stakeholders in the greater region using the key concepts in the theory of hybrid organizations. We find that despite moving towards a unified public transport market covering many counties the hybrid organizations use different governance structures and have different principles for sharing value creation. The closer cooperation paradoxically enhances competition in the regional railway market, both between subsidized travel cards and between subsidized and commercial railway services.
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| 5. |
- Bondemark, Lars, et al.
(författare)
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An updated systematic review regarding early Class II malocclusion correction
- 2019
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Ingår i: Journal of the World Federation of Orthodontists. - : Elsevier. - 2212-4438. ; 8:3, s. 89-94
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Forskningsöversikt (refereegranskat)abstract
- Background and aim: Class II malocclusion is one of the most common malocclusions in young children and a great deal of research on this topic has been undertaken. Despite this, there are still knowledge gaps on whether it is effective to treat these malocclusions early or what type of treatment should be performed. The aim of this article was to systematically review and update the quality of evidence for various treatment modalities considering Class II malocclusion correction before 10 years of age and with a focus on improvement of dental and skeletal relationships, soft tissue profile, relation to temporomandibular disorder (TMD), incidence on dental trauma, cost-effectiveness, and quality of life. Material and methods: Four databases were searched, from January 1960 to April 2019. Inclusion criteria were randomized or controlled trials reporting short- or long-term effects on dental or basal relationships, soft tissue profile, associations to TMD, quality of life, incidence of trauma, or costs. The quality of evidence was scored according to Grading of Recommendations Assessment Development and Evaluation. Results: A total of 300 publications were identified and 23 satisfied the inclusion criteria for full evaluation. The quality of evidence was high in 5 trials, moderate in 3, and low in 15. Conclusions: From the short- term perspective, there is a high level of evidence that early treatment reduces overjet and improves the anterior-posterior skeletal relationship. There is insufficient evidence about whether early treatment can reduce the incidence of trauma, is cost-effective, provides improved soft tissue profile, improves oral healtherelated quality of life, or possesses a risk of developing TMD. (C) 2019 World Federation of Orthodontists.
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| 6. |
- Bondemark, Lars
(författare)
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How to succeed with high quality randomised clinical trials in clinical orthodontic research
- 2019
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Ingår i: Journal of orthodontics. - : Sage Publications. - 1465-3125 .- 1465-3133. ; 46:1_Suppl, s. 13-16
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Tidskriftsartikel (refereegranskat)abstract
- One goal of producing relevant clinical research is to ensure that evidence-based research results are transformed into everyday clinical practice that help clinicians deliver high quality care. It also involves ensuring that the individual patient receives the most effective and least risky treatment, ultimately leading to an optimal treatment outcome both in the short and long term. Some fundamentals of evidence-based dentistry are highlighted with focus on performing orthodontic randomised controlled trials.
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| 7. |
- Bondemark, Lars, et al.
(författare)
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Intention to treat (ITT) analysis as reported in orthodontic randomized controlled trials-evaluations of methodology and recommendations for the accurate use of ITT analysis and handling dropouts
- 2018
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Ingår i: European Journal of Orthodontics. - : Oxford University Press. - 0141-5387 .- 1460-2210. ; 40:4, s. 409-413
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Tidskriftsartikel (refereegranskat)abstract
- Objective To systematically evaluate in five orthodontic journals how many randomized controlled trials (RCTs) use intention to treat (ITT) analysis and to assess the methodological quality of the ITT analysis, and finally, to demonstrate in an academic way how outcomes can be affected when not implementing the ITT analysis. Material and methods A search of the database, Medline, was performed via PubMed for publication type ‘randomized controlled trial’ published for each journal between 1 January 2013 and 30 April 2017. The five orthodontic journals assessed were the American Journal of Orthodontics and Dentofacial Orthopedics, Angle Orthodontics, European Journal of Orthodontics, Journal of Orthodontics, and Orthodontics and Craniofacial Research. Two independent reviewers assessed each RCT to determine whether the trial reported an ITT or not or if a per-protocol analysis was accomplished. Results The initial search generated 137 possible trials. After applying the inclusion and exclusion criteria, 90 RCTs were included and assessed. Seventeen out of 90 RCTs (18.9%) either reported an ITT analysis in the text and/or supported the ITT by flow diagrams or tables. However, six RCTs applied and reported the ITT analysis correctly, while the majority performed a per-protocol analysis instead. Conclusions Nearly all the trials that applied the ITT analysis incorrectly analysed the results using a per-protocol analysis, and thus, overestimating the results and/or having a reduced sample size which then could produce a diminished statistical power.
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| 8. |
- Bondemark, Lars
(författare)
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Publication pattern, study design, authors and countries involved in orthodontic RCTs : a bibliometric MEDLINE survey over the past 50 years
- 2019
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Ingår i: Journal of orthodontics. - : Sage Publications. - 1465-3125 .- 1465-3133. ; 46:2, s. 110-117
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVES: The objective of this study was to investigate the number and proportions, study design, journal publications, authors and countries involved in orthodontic randomised controlled trials (RCTs) over the past 50 years. METHOD: A MEDLINE database search (Entrez PubMed, http://www.ncbi.nlm.nih.gov ) was performed in November 2018 for RCT publications from 1 January 1968 to 31 December 2017. All orthodontic publications, clinical trials (CTs) or RCTs were selected. For each year from 1968 to 2017, the total number of orthodontic publications and total number of CTs and RCTs were computed. Following this, study design, journal publications, authors and countries involved in orthodontic RCTs were noted. RESULTS: The RCTs accounted for 0.1% of all orthodontic publications in the 1970s and 1980s, and, following this, the proportion of RCTs was increased and amounted to 2.7% over the past decade (2008-2017). The majority of RCTs were of single centre design (93.4%) and in 88.3% a parallel-arm design was performed. The United States and United Kingdom endorsed 16.9% and 15.5% of the RCTs, followed by Turkey (11.1%), Brazil (7.0%), Sweden (6.6%), China (5.6%), Italy (5.4%), and Germany (4.1%). Of all RCTs, 74.2% were published in 20 orthodontic journals and 25.8% in 81 non-orthodontic journals. The American Journal of Orthodontics and Dentofacial Orthopedics, Angle Orthodontist, European Journal of Orthodontics and Journal of Orthodontics contributed to 60.2% of all the RCTs. CONCLUSION: The considerable increase in orthodontic RCTs over the past 50 years implies an increased scientific impact of orthodontic literature.
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| 9. |
- Bondemark, Lars, et al.
(författare)
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Randomized controlled trial : the gold standard or an unobtainable fallacy?
- 2015
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Ingår i: European Journal of Orthodontics. - : Oxford University Press. - 0141-5387 .- 1460-2210. ; 37:5, s. 457-461
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Tidskriftsartikel (refereegranskat)abstract
- Background: This article is the result of a debate at the European Journal of Orthodontics Open Session in 2013 in Reykjavik, Iceland. Objective: The aim of this article is to highlight some of the strengths and weakness of clinical orthodontic research, with particular emphasis on randomized controlled trials (RCT). The ultimate aim of improving clinical orthodontic research in general. Design: This article is organized into two sections with arguments for and against RCTs. The backgrounds to evidence-based evaluation and the level or quality of evidence in trials are discussed. The article emphasises what makes high quality clinical research, and gives practical advice including examples of tips and potential pitfalls for those undertaking clinical research. Results and Conclusion: The overriding message is constructive and it is hoped that the article serves as an aid in evaluating, designing, conducting, and reporting clinical research.
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| 10. |
- Bondemark, Lars, et al.
(författare)
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RCTs are here to stay : Reply
- 2016
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Ingår i: European Journal of Orthodontics. - : Oxford University Press. - 0141-5387 .- 1460-2210. ; 38:3, s. 335-335
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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