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Low-frequency and r...
Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility
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Wessel, Jennifer (author)
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Chu, Audrey Y. (author)
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Willems, Sara M. (author)
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show more...
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Wang, Shuai (author)
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Yaghootkar, Hanieh (author)
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Brody, Jennifer A. (author)
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Dauriz, Marco (author)
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Hivert, Marie-France (author)
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Raghavan, Sridharan (author)
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Lipovich, Leonard (author)
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Hidalgo, Bertha (author)
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Fox, Keolu (author)
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Huffman, Jennifer E. (author)
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An, Ping (author)
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Lu, Yingchang (author)
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Rasmussen-Torvik, Laura J. (author)
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Grarup, Niels (author)
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Ehm, Margaret G. (author)
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Li, Li (author)
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- Baldridge, Abigail S. (author)
- Karolinska Institutet
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Stancakova, Alena (author)
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Abrol, Ravinder (author)
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Besse, Celine (author)
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Boland, Anne (author)
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Bork-Jensen, Jette (author)
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Fornage, Myriam (author)
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Freitag, Daniel F. (author)
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Garcia, Melissa E. (author)
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Guo, Xiuqing (author)
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Hara, Kazuo (author)
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Isaacs, Aaron (author)
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- Jakobsdottir, Johanna (author)
- Karolinska Institutet
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Lange, Leslie A. (author)
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Layton, Jill C. (author)
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Li, Man (author)
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Zhao, Jing Hua (author)
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Meidtner, Karina (author)
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Morrison, Alanna C. (author)
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Nalls, Mike A. (author)
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Peters, Marjolein J. (author)
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- Sabater-Lleal, Maria (author)
- Karolinska Institutet
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Schurmann, Claudia (author)
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Silveira, Angela (author)
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Smith, Albert V. (author)
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Southam, Lorraine (author)
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Stoiber, Marcus H. (author)
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Strawbridge, Rona J. (author)
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Taylor, Kent D. (author)
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- V Varga, Tibor (author)
- Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups
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- Allin, Kristine H. (author)
- Karolinska Institutet
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Amin, Najaf (author)
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Aponte, Jennifer L. (author)
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Aung, Tin (author)
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Barbieri, Caterina (author)
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Bihlmeyer, Nathan A. (author)
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Boehnke, Michael (author)
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Bombieri, Cristina (author)
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Bowden, Donald W. (author)
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Burns, Sean M. (author)
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Chen, Yuning (author)
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Chen, Yii-Deri (author)
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Cheng, Ching-Yu (author)
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Correa, Adolfo (author)
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Czajkowski, Jacek (author)
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Dehghan, Abbas (author)
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Ehret, Georg B. (author)
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Eiriksdottir, Gudny (author)
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Escher, Stefan A. (author)
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Farmaki, Aliki-Eleni (author)
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- Frånberg, Mattias (author)
- Stockholms universitet,Numerisk analys och datalogi (NADA),Science for Life Laboratory (SciLifeLab)
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Gambaro, Giovanni (author)
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Giulianini, Franco (author)
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Goddard, William A., III (author)
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Goel, Anuj (author)
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Gottesman, Omri (author)
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Grove, Megan L. (author)
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- Gustafsson, Stefan (author)
- Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab
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Hai, Yang (author)
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- Hallmans, Goeran (author)
- Umeå universitet,Näringsforskning,Enheten för biobanksforskning
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Heo, Jiyoung (author)
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Hoffmann, Per (author)
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Ikram, Mohammad K. (author)
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Jensen, Richard A. (author)
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Jorgensen, Marit E. (author)
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Jorgensen, Torben (author)
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Karaleftheri, Maria (author)
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Khor, Chiea C. (author)
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Kirkpatrick, Andrea (author)
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Kraja, Aldi T. (author)
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Kuusisto, Johanna (author)
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Lange, Ethan M. (author)
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Lee, I. T. (author)
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Lee, Wen-Jane (author)
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Leong, Aaron (author)
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Liao, Jiemin (author)
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Liu, Chunyu (author)
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Liu, Yongmei (author)
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Lindgren, Cecilia M. (author)
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Linneberg, Allan (author)
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Malerba, Giovanni (author)
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Mamakou, Vasiliki (author)
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Marouli, Eirini (author)
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Maruthur, Nisa M. (author)
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Matchan, Angela (author)
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McKean-Cowdin, Roberta (author)
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McLeod, Olga (author)
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Metcalf, Ginger A. (author)
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Mohlke, Karen L. (author)
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Muzny, Donna M. (author)
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Ntalla, Ioanna (author)
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Palmer, Nicholette D. (author)
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Pasko, Dorota (author)
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Peter, Andreas (author)
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Rayner, Nigel W. (author)
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- Renström, Frida (author)
- Lund University,Lunds universitet,Umeå universitet,Enheten för biobanksforskning,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups
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Rice, Ken (author)
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Sala, Cinzia F. (author)
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Sennblad, Bengt (author)
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Serafetinidis, Ioannis (author)
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Smith, Jennifer A. (author)
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Soranzo, Nicole (author)
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Speliotes, Elizabeth K. (author)
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Stahl, Eli A. (author)
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Stirrups, Kathleen (author)
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Tentolouris, Nikos (author)
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Thanopoulou, Anastasia (author)
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Torres, Mina (author)
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Traglia, Michela (author)
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Tsafantakis, Emmanouil (author)
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Javad, Sundas (author)
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Yanek, Lisa R. (author)
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Zengini, Eleni (author)
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Becker, Diane M. (author)
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Bis, Joshua C. (author)
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Brown, James B. (author)
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Cupples, L. Adrienne (author)
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Hansen, Torben (author)
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- Ingelsson, Erik (author)
- Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab
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Karter, Andrew J. (author)
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Lorenzo, Carlos (author)
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Mathias, Rasika A. (author)
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Norris, Jill M. (author)
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Peloso, Gina M. (author)
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Sheu, Wayne H. -H. (author)
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Toniolo, Daniela (author)
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Vaidya, Dhananjay (author)
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Varma, Rohit (author)
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Wagenknecht, Lynne E. (author)
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Boeing, Heiner (author)
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Bottinger, Erwin P. (author)
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Dedoussis, George (author)
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Deloukas, Panos (author)
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Ferrannini, Ele (author)
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Franco, Oscar H. (author)
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- Franks, Paul W. (author)
- Lund University,Lunds universitet,Umeå universitet,Medicin,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups
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Gibbs, Richard A. (author)
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Gudnason, Vilmundur (author)
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Hamsten, Anders (author)
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Harris, Tamara B. (author)
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Hattersley, Andrew T. (author)
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Hayward, Caroline (author)
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Hofman, Albert (author)
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- Jansson, Jan-Håkan (author)
- Umeå universitet,Medicin
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Langenberg, Claudia (author)
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Launer, Lenore J. (author)
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Levy, Daniel (author)
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Oostra, Ben A. (author)
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O'Donnell, Christopher J. (author)
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O'Rahilly, Stephen (author)
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Padmanabhan, Sandosh (author)
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Pankow, James S. (author)
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Polasek, Ozren (author)
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Province, Michael A. (author)
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Rich, Stephen S. (author)
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Ridker, Paul M. (author)
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Rudan, Igor (author)
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Schulze, Matthias B. (author)
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Smith, Blair H. (author)
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Uitterlinden, Andre G. (author)
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Walker, Mark (author)
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Watkins, Hugh (author)
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Wong, Tien Y. (author)
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Zeggini, Eleftheria (author)
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Laakso, Markku (author)
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Borecki, Ingrid B. (author)
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Chasman, Daniel I. (author)
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Pedersen, Oluf (author)
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Psaty, Bruce M. (author)
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Tai, E. Shyong (author)
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van Duijn, Cornelia M. (author)
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Wareham, Nicholas J. (author)
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Waterworth, Dawn M. (author)
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Boerwinkle, Eric (author)
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Kao, W. H. Linda (author)
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Florez, Jose C. (author)
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Loos, Ruth J. F. (author)
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Wilson, James G. (author)
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Frayling, Timothy M. (author)
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Siscovick, David S. (author)
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Dupuis, Josee (author)
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Rotter, Jerome I. (author)
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Meigs, James B. (author)
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Scott, Robert A. (author)
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Goodarzi, Mark O. (author)
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Sharp, Stephen J. (author)
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Forouhi, Nita G. (author)
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Kerrison, Nicola D. (author)
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Lucarelli, Debora M. E. (author)
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Sims, Matt (author)
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Barroso, Ines (author)
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McCarthy, Mark I. (author)
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Arriola, Larraitz (author)
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Balkau, Beverley (author)
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Barricarte, Aurelio (author)
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Gonzalez, Carlos (author)
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Grioni, Sara (author)
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Kaaks, Rudolf (author)
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Key, Timothy J. (author)
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Navarro, Carmen (author)
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Nilsson, Peter M. (author)
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Overvad, Kim (author)
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Palli, Domenico (author)
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Panico, Salvatore (author)
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Quiros, J. Ramon (author)
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- Rolandsson, Olov (author)
- Umeå universitet,Enheten för biobanksforskning
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Sacerdote, Carlotta (author)
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Sanchez, Maria-Jose (author)
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Slimani, Nadia (author)
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Tjonneland, Anne (author)
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Tumino, Rosario (author)
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van der A, Daphne L. (author)
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van der Schouw, Yvonne T. (author)
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Riboli, Elio (author)
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(creator_code:org_t)
- 2015-01-29
- 2015
- English.
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In: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 6
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http://www.ncbi.nlm....
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://lup.lub.lu.s...
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https://urn.kb.se/re...
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Abstract
Subject headings
Close
- Fasting glucose and insulin are intermediate traits for type 2 diabetes. Here we explore the role of coding variation on these traits by analysis of variants on the HumanExome BeadChip in 60,564 non-diabetic individuals and in 16,491 T2D cases and 81,877 controls. We identify a novel association of a low-frequency nonsynonymous SNV in GLP1R (A316T; rs10305492; MAF = 1.4%) with lower FG (beta = -0.09 +/- 0.01 mmol l(-1), P = 3.4 x 10(-12)), T2D risk (OR[95% CI] = 0.86[0.76-0.96], P = 0.010), early insulin secretion (beta = -0.07 +/- 0.035 pmol(insulin) mmol(glucose)(-1), P = 0.048), but higher 2-h glucose (beta = 0.16 +/- 0.05 mmol l(-1), P = 4.3 x 10(-4)). We identify a gene-based association with FG at G6PC2 (p(SKAT) = 6.8 x 10(-6)) driven by four rare protein-coding SNVs (H177Y, Y207S, R283X and S324P). We identify rs651007 (MAF = 20%) in the first intron of ABO at the putative promoter of an antisense lncRNA, associating with higher FG (beta = 0.02 +/- 0.004 mmol l(-1), P = 1.3 x 10(-8)). Our approach identifies novel coding variant associations and extends the allelic spectrum of variation underlying diabetes-related quantitative traits and T2D susceptibility.
Subject headings
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Wessel, Jennifer
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Chu, Audrey Y.
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Willems, Sara M.
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Wang, Shuai
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Yaghootkar, Hani ...
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Brody, Jennifer ...
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show more...
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Dauriz, Marco
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Hivert, Marie-Fr ...
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Raghavan, Sridha ...
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Lipovich, Leonar ...
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Hidalgo, Bertha
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Fox, Keolu
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Huffman, Jennife ...
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An, Ping
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Lu, Yingchang
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Rasmussen-Torvik ...
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Grarup, Niels
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Ehm, Margaret G.
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Li, Li
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Baldridge, Abiga ...
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Stancakova, Alen ...
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Abrol, Ravinder
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Besse, Celine
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Boland, Anne
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Bork-Jensen, Jet ...
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Fornage, Myriam
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Freitag, Daniel ...
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Garcia, Melissa ...
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Guo, Xiuqing
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Hara, Kazuo
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Isaacs, Aaron
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Jakobsdottir, Jo ...
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Lange, Leslie A.
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Layton, Jill C.
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Li, Man
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Zhao, Jing Hua
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Meidtner, Karina
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Morrison, Alanna ...
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Nalls, Mike A.
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Peters, Marjolei ...
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Sabater-Lleal, M ...
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Schurmann, Claud ...
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Silveira, Angela
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Smith, Albert V.
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Southam, Lorrain ...
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Stoiber, Marcus ...
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Strawbridge, Ron ...
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Taylor, Kent D.
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V Varga, Tibor
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Allin, Kristine ...
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Amin, Najaf
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Aponte, Jennifer ...
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Aung, Tin
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Barbieri, Cateri ...
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Bihlmeyer, Natha ...
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Boehnke, Michael
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Bombieri, Cristi ...
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Bowden, Donald W ...
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Burns, Sean M.
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Chen, Yuning
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Chen, Yii-Deri
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Cheng, Ching-Yu
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Correa, Adolfo
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Czajkowski, Jace ...
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Dehghan, Abbas
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Ehret, Georg B.
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Eiriksdottir, Gu ...
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Escher, Stefan A ...
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Farmaki, Aliki-E ...
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Frånberg, Mattia ...
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Gambaro, Giovann ...
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Giulianini, Fran ...
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Goddard, William ...
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Goel, Anuj
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Gottesman, Omri
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Grove, Megan L.
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Gustafsson, Stef ...
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Hai, Yang
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Hallmans, Goeran
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Heo, Jiyoung
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Hoffmann, Per
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Ikram, Mohammad ...
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Jensen, Richard ...
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Jorgensen, Marit ...
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Jorgensen, Torbe ...
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Karaleftheri, Ma ...
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Khor, Chiea C.
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Kirkpatrick, And ...
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Kraja, Aldi T.
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Kuusisto, Johann ...
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Lange, Ethan M.
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Lee, I. T.
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Lee, Wen-Jane
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Leong, Aaron
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Liao, Jiemin
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Liu, Chunyu
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Liu, Yongmei
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Lindgren, Cecili ...
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Linneberg, Allan
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Malerba, Giovann ...
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Mamakou, Vasilik ...
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Marouli, Eirini
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Maruthur, Nisa M ...
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Matchan, Angela
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McKean-Cowdin, R ...
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McLeod, Olga
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Metcalf, Ginger ...
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Mohlke, Karen L.
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Muzny, Donna M.
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Ntalla, Ioanna
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Palmer, Nicholet ...
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Pasko, Dorota
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Peter, Andreas
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Rayner, Nigel W.
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Renström, Frida
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Rice, Ken
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Sala, Cinzia F.
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Sennblad, Bengt
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Serafetinidis, I ...
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Smith, Jennifer ...
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Soranzo, Nicole
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Speliotes, Eliza ...
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Stahl, Eli A.
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Stirrups, Kathle ...
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Tentolouris, Nik ...
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Thanopoulou, Ana ...
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Torres, Mina
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Traglia, Michela
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Tsafantakis, Emm ...
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Javad, Sundas
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Yanek, Lisa R.
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Zengini, Eleni
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Becker, Diane M.
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Bis, Joshua C.
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Brown, James B.
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Cupples, L. Adri ...
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Hansen, Torben
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Ingelsson, Erik
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Karter, Andrew J ...
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Lorenzo, Carlos
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Mathias, Rasika ...
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Norris, Jill M.
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Peloso, Gina M.
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Sheu, Wayne H. - ...
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Toniolo, Daniela
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Vaidya, Dhananja ...
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Varma, Rohit
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Wagenknecht, Lyn ...
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Boeing, Heiner
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Bottinger, Erwin ...
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Dedoussis, Georg ...
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Deloukas, Panos
-
Ferrannini, Ele
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Franco, Oscar H.
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Franks, Paul W.
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Gibbs, Richard A ...
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Gudnason, Vilmun ...
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Hamsten, Anders
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Harris, Tamara B ...
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Hattersley, Andr ...
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Hayward, Carolin ...
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Hofman, Albert
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Jansson, Jan-Håk ...
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Langenberg, Clau ...
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Launer, Lenore J ...
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Levy, Daniel
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Oostra, Ben A.
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O'Donnell, Chris ...
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O'Rahilly, Steph ...
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Padmanabhan, San ...
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Pankow, James S.
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Polasek, Ozren
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Province, Michae ...
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Rich, Stephen S.
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Ridker, Paul M.
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Rudan, Igor
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Schulze, Matthia ...
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Smith, Blair H.
-
Uitterlinden, An ...
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Walker, Mark
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Watkins, Hugh
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Wong, Tien Y.
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Zeggini, Elefthe ...
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Laakso, Markku
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Borecki, Ingrid ...
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Chasman, Daniel ...
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Pedersen, Oluf
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Psaty, Bruce M.
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Tai, E. Shyong
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van Duijn, Corne ...
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Wareham, Nichola ...
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Waterworth, Dawn ...
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Boerwinkle, Eric
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Kao, W. H. Linda
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Florez, Jose C.
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Loos, Ruth J. F.
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Wilson, James G.
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Frayling, Timoth ...
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Siscovick, David ...
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Dupuis, Josee
-
Rotter, Jerome I ...
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Meigs, James B.
-
Scott, Robert A.
-
Goodarzi, Mark O ...
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Sharp, Stephen J ...
-
Forouhi, Nita G.
-
Kerrison, Nicola ...
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Lucarelli, Debor ...
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Sims, Matt
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Barroso, Ines
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McCarthy, Mark I ...
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Arriola, Larrait ...
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Balkau, Beverley
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Barricarte, Aure ...
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Gonzalez, Carlos
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Grioni, Sara
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Kaaks, Rudolf
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Key, Timothy J.
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Navarro, Carmen
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Nilsson, Peter M ...
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Overvad, Kim
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Palli, Domenico
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Panico, Salvator ...
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Quiros, J. Ramon
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Rolandsson, Olov
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Sacerdote, Carlo ...
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Sanchez, Maria-J ...
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Slimani, Nadia
-
Tjonneland, Anne
-
Tumino, Rosario
-
van der A, Daphn ...
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van der Schouw, ...
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Riboli, Elio
-
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- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
-
and Biological Scien ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Medical Biotechn ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
- Articles in the publication
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Nature Communica ...
- By the university
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Stockholm University
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Umeå University
-
Lund University
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Karolinska Institutet
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Uppsala University