| 1. |
- Abelev, Betty, et al.
(författare)
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Long-range angular correlations on the near and away side in p-Pb collisions at root S-NN=5.02 TeV
- 2013
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Ingår i: Physics Letters. Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier BV. - 0370-2693. ; 719:1-3, s. 29-41
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Tidskriftsartikel (refereegranskat)abstract
- Angular correlations between charged trigger and associated particles are measured by the ALICE detector in p-Pb collisions at a nucleon-nucleon centre-of-mass energy of 5.02 TeV for transverse momentum ranges within 0.5 < P-T,P-assoc < P-T,P-trig < 4 GeV/c. The correlations are measured over two units of pseudorapidity and full azimuthal angle in different intervals of event multiplicity, and expressed as associated yield per trigger particle. Two long-range ridge-like structures, one on the near side and one on the away side, are observed when the per-trigger yield obtained in low-multiplicity events is subtracted from the one in high-multiplicity events. The excess on the near-side is qualitatively similar to that recently reported by the CMS Collaboration, while the excess on the away-side is reported for the first time. The two-ridge structure projected onto azimuthal angle is quantified with the second and third Fourier coefficients as well as by near-side and away-side yields and widths. The yields on the near side and on the away side are equal within the uncertainties for all studied event multiplicity and p(T) bins, and the widths show no significant evolution with event multiplicity or p(T). These findings suggest that the near-side ridge is accompanied by an essentially identical away-side ridge. (c) 2013 CERN. Published by Elsevier B.V. All rights reserved.
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| 2. |
- Abelev, Betty, et al.
(författare)
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Measurement of prompt J/psi and beauty hadron production cross sections at mid-rapidity in pp collisions at root s=7 TeV
- 2012
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Ingår i: Journal of High Energy Physics. - 1029-8479. ; :11
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Tidskriftsartikel (refereegranskat)abstract
- The ALICE experiment at the LHC has studied J/psi production at mid-rapidity in pp collisions at root s = 7 TeV through its electron pair decay on a data sample corresponding to an integrated luminosity L-int = 5.6 nb(-1). The fraction of J/psi from the decay of long-lived beauty hadrons was determined for J/psi candidates with transverse momentum p(t) > 1,3 GeV/c and rapidity vertical bar y vertical bar < 0.9. The cross section for prompt J/psi mesons, i.e. directly produced J/psi and prompt decays of heavier charmonium states such as the psi(2S) and chi(c) resonances, is sigma(prompt J/psi) (p(t) > 1.3 GeV/c, vertical bar y vertical bar < 0.9) = 8.3 +/- 0.8(stat.) +/- 1.1 (syst.)(-1.4)(+1.5) (syst. pol.) mu b. The cross section for the production of b-hadrons decaying to J/psi with p(t) > 1.3 GeV/c and vertical bar y vertical bar < 0.9 is a sigma(J/psi <- hB) (p(t) > 1.3 GeV/c, vertical bar y vertical bar < 0.9) = 1.46 +/- 0.38 (stat.)(-0.32)(+0.26) (syst.) mu b. The results are compared to QCD model predictions. The shape of the p(t) and y distributions of b-quarks predicted by perturbative QCD model calculations are used to extrapolate the measured cross section to derive the b (b) over bar pair total cross section and d sigma/dy at mid-rapidity.
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| 3. |
- Abelev, Betty, et al.
(författare)
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Underlying Event measurements in pp collisions at root s=0.9 and 7 TeV with the ALICE experiment at the LHC
- 2012
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Ingår i: Journal of High Energy Physics. - 1029-8479. ; :7
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Tidskriftsartikel (refereegranskat)abstract
- We present measurements of Underlying Event observables in pp collisions at root s = 0 : 9 and 7 TeV. The analysis is performed as a function of the highest charged-particle transverse momentum p(T),L-T in the event. Different regions are defined with respect to the azimuthal direction of the leading (highest transverse momentum) track: Toward, Transverse and Away. The Toward and Away regions collect the fragmentation products of the hardest partonic interaction. The Transverse region is expected to be most sensitive to the Underlying Event activity. The study is performed with charged particles above three different p(T) thresholds: 0.15, 0.5 and 1.0 GeV/c. In the Transverse region we observe an increase in the multiplicity of a factor 2-3 between the lower and higher collision energies, depending on the track p(T) threshold considered. Data are compared to PYTHIA 6.4, PYTHIA 8.1 and PHOJET. On average, all models considered underestimate the multiplicity and summed p(T) in the Transverse region by about 10-30%.
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| 4. |
- Barrington, Sally F., et al.
(författare)
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Concordance between four European centres of PET reporting criteria designed for use in multicentre trials in Hodgkin lymphoma
- 2010
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Ingår i: European Journal of Nuclear Medicine and Molecular Imaging. - : Springer Science and Business Media LLC. - 1619-7070 .- 1619-7089. ; 37:10, s. 1824-1833
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Tidskriftsartikel (refereegranskat)abstract
- To determine if PET reporting criteria for the Response Adapted Treatment in Hodgkin Lymphoma (RATHL) trial could enable satisfactory agreement to be reached between 'core' laboratories operating in different countries. Four centres reported scans from 50 patients with stage II-IV HL, acquired before and after two cycles of Adriamycin/bleomycin/vinblastine/dacarbazine. A five-point scale was used to score response scans using 'normal' mediastinum and liver as reference levels. Centres read scans independently of each other. The level of agreement between centres was determined assuming (1) that uptake in sites involved at diagnosis that was higher than liver uptake represented disease (conservative reading), and (2) that uptake in sites involved at diagnosis that was higher than mediastinal uptake represented disease (sensitive reading). There was agreement that the response scan was 'positive' or 'negative' for lymphoma in 44 patients with a conservative reading and in 41 patients with a sensitive reading. Kappa was 0.85 (95% CI 0.74-0.96) for conservative reading and 0.79 (95% CI 0.67-0.90) for sensitive reading. Agreement was reached in 46 and 44 patients after discussion for the conservative and sensitive readings, respectively. The criteria developed for reporting in the RATHL trial are sufficiently robust to be used in a multicentre setting.
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| 5. |
- Bjurberg, Maria, et al.
(författare)
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Clinical Impact of 2-Deoxy-2-[18F]fluoro-D-Glucose (FDG)-Positron Emission Tomography (PET) on Treatment Choice in Recurrent Cancer of the Cervix Uteri.
- 2013
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Ingår i: International Journal of Gynecological Cancer. - 1048-891X. ; 23:9, s. 1642-1646
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Tidskriftsartikel (refereegranskat)abstract
- The superiority of positron emission tomography (PET) with 2-deoxy-2-[18F]fluoro-D-glucose (FDG) over computed tomography and magnetic resonance imaging in detecting recurrent cervical cancer and determining the extent of the disease has been demonstrated in several clinical trials. However, there is a lack of data concerning the clinical impact of the extra findings. We report here a prospective clinical study aimed at investigating the clinical impact of FDG-PET findings on the treatment plans in recurrent cervical cancer.
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| 6. |
- Bjurberg, Maria, et al.
(författare)
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Early metabolic flare in squamous cell carcinoma after chemotherapy is a marker of treatment sensitivity in vitro
- 2010
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Ingår i: Nuclear medicine and molecular imaging. - : Springer. - 1869-3474 .- 1869-3482. ; 44:3, s. 165-169
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Tidskriftsartikel (refereegranskat)abstract
- Purpose Early metabolic response with a decrease in glucose demand after cytotoxic treatment has been reported to precede tumor volume shrinkage. However, preclinical studies report of a very early rise in metabolism, a flare, following treatment. To elucidate these observations, we performed an experimental study on early metabolic response with sequential analysis of metabolic changes. Methods Three squamous cell carcinoma cell lines and one nontumorigenic cell line were exposed to cisplatin. The uptake of the fluorescent glucose analogue 2-NBDG was examined at days 1-6 using fluorescence microscopy. The relation between 2-NBDG-uptake and cell survival was evaluated. Results The tumor cells exhibited a high uptake of 2-NBDG, whereas the uptake in the nonmalignant cells was low. The more cisplatin sensitive cell lines exhibited a more pronounced metabolic flare than the less sensitive cell line. Conclusion A metabolic flare was a very early sign of treatment response and potentially it could be used as an early marker of treatment sensitivity.
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| 7. |
- Blank Savukinas, Ulrika, et al.
(författare)
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Angptl4 maintains in vivo repopulation capacity of CD34(+) human cord blood cells.
- 2012
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Ingår i: European Journal of Haematology. - : Wiley. - 1600-0609 .- 0902-4441. ; 89:3, s. 198-205
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVES: Methods to expand hematopoietic stem cells (HSCs) ex vivo encompass an attractive approach that would substantially broaden the clinical applicability of HSCs derived from cord blood. Recently, members of the Angiopoietin-like (Angptl) family of growth factors were shown to expand both murine and human HSCs. Specifically, Angptl5 has been implicated in the expansion of human NOD-SCID-repopulating cells (SRCs) ex vivo. Here, we sought to evaluate the potential of additional Angptls to expand human SRCs from cord blood. Additionally, the purpose of this study was to evaluate the reproducibility of Angptl-mediated expansion of SRCs across independent experiments. METHODS: Human CD34(+) cells from cord blood were cultured in vitro for eleven or eight days in the presence or absence of Angptls. The reconstitution capacity of expanded cells was subsequently measured in vivo by transplantation into NOD-SCID or NSG mice, and compared to that of uncultured cells. RESULTS: We report here that Angptl4 functions to maintain SRC-activity of CD34(+) CB-derived cells ex vivo as assayed in NOD-SCID and NSG mice. However, all Angptls tested, including Angptl1, 4, and 5, were associated with variation between experiments. CONCLUSION: Our findings indicate that Angptl4 and Angptl5 can lead to increased engraftment capacity of SRCs, but more frequently these factors are associated with maintenance of SRC-activity during ex vivo culture. Thus, Angptl-mediated expansion of SRCs ex vivo is associated with more inter-experimental variation than previously thought. We conclude that Angptls would be useful in instances where there is a need to maintain HSCs ex vivo, such as during transduction for gene therapy applications.
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| 8. |
- Ekblom, Örjan, et al.
(författare)
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Predictors of adolescent fitness levels among Swedish adolescents, a longitudinal study
- 2012
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Ingår i: Journal of Science and Medicine in Sport. - : Elsevier BV. - 1440-2440. ; , s. S185-
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Introduction: It has been consistently demonstrated that low aerobic fitness is causally linked to increased cardio-metabolic risk. Aerobic fitness has also been causally related to cognitive function. From adolescence and onwards, the inter-individual stability ("tracking") in fitness is fairly high. An individual's fitness level in adolescence is therefore a central determinant for future health. However, childhood predictors of adolescent fitness levels are largely unknown. The present study aimed at identifying personal, school-specific and structural determinants in childhood (age 10 yrs) for adolescent aerobic fitness (at age 16 yrs).Methods: Body mass index-based overweight status (normal weight vs overweight/obese, according to Cole et al.) and gross motor skills (based on the Tidén-Nyberg test) were measured at baseline in 209 Swedish children (mean [SD] age 9.8 [0.60] yrs) from randomly selected schools on Sweden. Immigration status (self-report) and average household income in quartiles on community level (register obtained) were used as possible structural confounders. Data on educational status of the PE teacher and lesson structure (gender-separated vs mixed classes) was obtained from the PE teacher. At the reexamination (at age 15.8 [0.33] yrs), aerobic fitness was estimated using the Åstrand-Ryhming nomogram. Low aerobic fitness was defined as below the first quartile (29.7 mL x min-1 x kg-1). Risk for low aerobic fitness was assessed using logistic regressionResults: Risk for low aerobic fitness at follow-up was lower in children who were normal weight (OR: 0.23.95% CI: 0.10 to 0.49) and in children with trained PE-teachers (OR: 0.40, 95% CI: 0.17 to 0.93), but higher among children with poor gross motor skills (OR:1.84, 95% CI 1.08 to 3.13) at baseline. Gender, immigration history, neighborhood economical status and lesson structure were all non-significant predictors of low adolescent fitness.Discussion: The results stress the importance for early overweight prevention and treatment and for professional identification and treatment of children with impaired gross motor skills at young ages. In Sweden, a lagre proportion of PE-teachers in lower grades lack formal PE-teacher education, which according to the present study poses a threat to children's future health. Early screening and treatment of children with limited motor proficiencies seems may help children adapting a physically active lifestyle and avoiding low fitness levels in adolescence and young adulthood.
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| 9. |
- Ekblom, Örjan, et al.
(författare)
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Predictors of perceived competence in physical activities (PCPA) among Swedish adolescents, a longitudinal study
- 2012
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Ingår i: Journal of Science and Medicine in Sport. - : Elsevier BV. - 1440-2440. ; , s. S113-
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Introduction: An individual's perceived competence in physical activities (PCPA) has been proven a powerful predictor for future physical activity. However, the perception of one¥s competence may differ over time, especially during childhood and adolescence but also between types of physical activities or tasks. Further, the predictors for PCPA are largely unknown, but overweight status and gross motor skills have been proposed as candidates. We sought to identify predictors for general PCPA in Swedish adolescents, and PCPA in three highly prevalent forms of physical activities in Swedish physical education (PE), namely swimming, aerobics and soccer.Methods: Body mass index-based overweight status (normal weight vs overweight/obese, according to Cole et al.) and gross motor skills (based on the TidÈn-Nyberg test) were measured in 352 Swedish children (160 girls and 192 boys) at baseline (age 10). Immigration status (self-report) and average community household income level (quartiles, register obtained) at 10 yrs were used as possible socio-cultural confounders. Data on educational status of the PE teacher responsible for education at age 10 yrs was obtained by self-report from the teachers. Self reported data on general PCPA and PCPA in soccer, swimming and aerobics at 16 yrs was obtained at follow-up and predictors for PCPA was identified using logistic regression.Results: Being overweight or obese (OR: 2.27, 95% CI: 1.18–4.38) and attending PE classes with unqualified teachers (OR: 2.41, 95% CI: 1.36–4.27) at age 10 yrs were both risk factors for low general PCPA a age 16 yrs. Concerning the selected activities, being overweight or obese at age 10 yrs predicted low PCPA in swimming (OR: 2.67, 95% CI:1.31–5.46) but not in the other activities at age 16 yrs. Poor gross motor skills at age 10 yrs predicted low PCPA at 16 yrs only in soccer (OR:1.48, 95% CI: 1.02–2.13). Female gender (OR: 0.21, 95% CI: 0.13–0.38), and higher socioeconomic status (OR: 0.71 per quartile, 95% CI: 0.55–0.92)at age 10 yrs were both found to be associated to lower risk for low PCPA in aerobics.Discussion: Overweight status and educational status of the PE teacher both affect the risk of having low general PCPA. The effect of gender, overweight status, gross motor skill and socio-economy seem to differ between specific activities, indicating that PCPA may be task specific in adolescents. These results may serve as background when planning physical activity interventions. Further, they stress the need for professional PE teachers to teach in younger classes.
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| 10. |
- Nordmark, Gunnel, et al.
(författare)
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Association of EBF1, FAM167A(C8orf13)-BLK and TNFSF4 gene variants with primary Sjögren's syndrome
- 2011
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Ingår i: Genes and Immunity. - : Springer Science and Business Media LLC. - 1466-4879 .- 1476-5470. ; 12:2, s. 100-109
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Tidskriftsartikel (refereegranskat)abstract
- We performed a candidate gene association study in 540 patients with primary Sjögren's Syndrome (SS) from Sweden (n=344) and Norway (n=196) and 532 controls (n=319 Swedish, n=213 Norwegian). A total of 1139 single-nucleotide polymorphisms (SNPs) in 84 genes were analyzed. In the meta-analysis of the Swedish and Norwegian cohorts, we found high signals for association between primary SS and SNPs in three gene loci, not previously associated with primary SS. These are the early B-cell factor 1 (EBF1) gene, P=9.9 × 10−5, OR 1.68, the family with sequence similarity 167 member A–B-lymphoid tyrosine kinase (FAM167A–BLK) locus, P=4.7 × 10−4, OR 1.37 and the tumor necrosis factor superfamily (TNFSF4=Ox40L) gene, P=7.4 × 10−4, OR 1.34. We also confirmed the association between primary SS and the IRF5/TNPO3 locus and the STAT4 gene. We found no association between the SNPs in these five genes and the presence of anti-SSA/anti-SSB antibodies. EBF1, BLK and TNFSF4 are all involved in B-cell differentiation and activation, and we conclude that polymorphisms in several susceptibility genes in the immune system contribute to the pathogenesis of primary SS.
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