Search: (WFRF:(Buckland Genevieve)) pers:(Norat Teresa) pers:(Riboli Elio) pers:(Key Timothy J)
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Dietary glycemic in...
Dietary glycemic index and glycemic load and breast cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC)
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Romieu, Isabelle (author)
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Ferrari, Pietro (author)
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Rinaldi, Sabina (author)
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show more...
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Slimani, Nadia (author)
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Jenab, Mazda (author)
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Olsen, Anja (author)
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Tjonneland, Anne (author)
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Overvad, Kim (author)
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Boutron-Ruault, Marie-Christine (author)
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Lajous, Martin (author)
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Kaaks, Rudolf (author)
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Teucher, Birgit (author)
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Boeing, Heiner (author)
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Trichopoulou, Antonia (author)
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Naska, Androniki (author)
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Vasilopoulo, Effie (author)
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Sacerdote, Carlotta (author)
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Tumino, Rosario (author)
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Masala, Giovanna (author)
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Sieri, Sabina (author)
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Panico, Salvatore (author)
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Bueno-de-Mesquita, H Bas (author)
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Van-der-A, Daphne (author)
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van Gils, Carla H (author)
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Peeters, Petra HM (author)
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Lund, Eiliv (author)
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Skeie, Guri (author)
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Asli, Lene Angell (author)
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Rodriguez, Laudina (author)
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Navarro, Carmen (author)
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Amiano, Pilar (author)
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Sanchez, Maria-Jose (author)
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Barricarte, Aurelio (author)
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Buckland, Genevieve (author)
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- Sonestedt, Emily (author)
- Lund University,Lunds universitet,Nutritionsepidemiologi,Forskargrupper vid Lunds universitet,Nutrition Epidemiology,Lund University Research Groups
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- Wirfält, Elisabet (author)
- Lund University,Lunds universitet,Nutritionsepidemiologi,Forskargrupper vid Lunds universitet,Nutrition Epidemiology,Lund University Research Groups
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- Hallmans, Göran (author)
- Umeå universitet,Näringsforskning
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- Johansson, Ingegerd (author)
- Umeå universitet,Kariologi
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Key, Timothy J (author)
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Allen, Naomi E (author)
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Khaw, Kay-Tee (author)
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Wareham, Nicholas J (author)
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Norat, Teresa (author)
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Riboli, Elio (author)
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Clavel-Chapelon, Francoise (author)
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(creator_code:org_t)
- Elsevier BV, 2012
- 2012
- English.
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In: American Journal of Clinical Nutrition. - : Elsevier BV. - 0002-9165 .- 1938-3207. ; 96:2, s. 345-355
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https://academic.oup...
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.3...
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https://lup.lub.lu.s...
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Abstract
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- Background: The glycemic potential of a diet is associated with chronically elevated insulin concentrations, which may augment breast cancer (BC) risk by stimulating insulin receptor or by affecting insulin-like growth factor I (IGF-I)-mediated mitogenesis. It is unclear whether this effect differs by BC phenotype.Objective: The objective was to investigate the relation between glycemic index (GI), glycemic load (GL), and total carbohydrate intake with BC by using data from the European Prospective Investigation into Cancer and Nutrition (EPIC).Design: We identified 11,576 women with invasive BC among 334,849 EPIC women aged 34-66 y (5th to 95th percentiles) at baseline over a median follow-up of 11.5 y. Dietary GI and GL were calculated from country-specific dietary questionnaires. We used multivariable Cox proportional hazards models to quantify the association between GI. GL, and carbohydrate intake and BC risk. BC tumors were classified by receptor status.Results: Overall GI, GL, and carbohydrates were not related to BC. Among postmenopausal women, GL and carbohydate intake were significantly associated with an increased risk of estrogen receptor negative (ER-) BC when extreme quintiles (Q) were compared [multivariable HRQ5-Q1 (95% CI) = 1.36 (1.02, 1.82; P-trend = 0.010) and HRQ5-Q1 = 1.41 (1.05, 1.89; P-trend = 0.009), respectively]. Further stratification by progesterone receptor (PR) status showed slightly stronger associations with ER (-)/PR- BC [HRQ5-Q1 (95% CI) = 1.48 (1.07, 2.05; P-trend = 0.010) for GL and HRQ5-Q1 = 1.62 (1.15, 2.30; P-trend = 0.005) for carbohydrates]. No significant association with ER-positive BC was observed.Conclusion: Our results indicate that a diet with a high GL and carbohydrate intake is positively associated with an increased risk of developing ER- and ER-/PR- BC among postmenopausal women. Am J Clin Nutr 2012;96:345-55.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Romieu, Isabelle
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Ferrari, Pietro
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Rinaldi, Sabina
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Slimani, Nadia
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Jenab, Mazda
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Olsen, Anja
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show more...
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Tjonneland, Anne
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Overvad, Kim
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Boutron-Ruault, ...
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Lajous, Martin
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Kaaks, Rudolf
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Teucher, Birgit
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Boeing, Heiner
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Trichopoulou, An ...
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Naska, Androniki
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Vasilopoulo, Eff ...
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Sacerdote, Carlo ...
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Tumino, Rosario
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Masala, Giovanna
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Sieri, Sabina
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Panico, Salvator ...
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Bueno-de-Mesquit ...
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Van-der-A, Daphn ...
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van Gils, Carla ...
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Peeters, Petra H ...
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Lund, Eiliv
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Skeie, Guri
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Asli, Lene Angel ...
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Rodriguez, Laudi ...
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Navarro, Carmen
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Amiano, Pilar
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Sanchez, Maria-J ...
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Barricarte, Aure ...
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Buckland, Genevi ...
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Sonestedt, Emily
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Wirfält, Elisabe ...
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Hallmans, Göran
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Johansson, Ingeg ...
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Key, Timothy J
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Allen, Naomi E
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Khaw, Kay-Tee
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Wareham, Nichola ...
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Norat, Teresa
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Riboli, Elio
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Clavel-Chapelon, ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Nutrition and Di ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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American Journal ...
- By the university
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Umeå University
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Lund University