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Additional booster ...
Additional booster doses in patients with chronic lymphocytic leukemia induce humoral and cellular immune responses to SARS-CoV-2 similar to natural infection regardless ongoing treatments : A study by ERIC, the European Research Initiative on CLL
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- Campanella, A. (författare)
- Vita Salute San Raffaele University, Milan, Italy; IRCCS San Raffaele Hospital, Milan, Italy
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- Capasso, A. (författare)
- Vita Salute San Raffaele University, Milan, Italy; IRCCS San Raffaele Hospital, Milan, Italy
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- Heltai, S. (författare)
- IRCCS San Raffaele Hospital, Milan, Italy
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- Taccetti, C. (författare)
- Vita Salute San Raffaele University, Milan, Italy; IRCCS San Raffaele Hospital, Milan, Italy
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- Albi, E. (författare)
- IRCCS San Raffaele Hospital, Milan, Italy
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- Herishanu, Y. (författare)
- Tel Aviv Sourasky Medical Center, Tel Aviv, Israel; Tel Aviv University, Tel-Aviv, Israel
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- Haggenburg, S. (författare)
- Amsterdam UMC, Amsterdam, The Netherlands
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- Chatzikonstantinou, T. (författare)
- Centre for Research and Technology Hellas, Thessaloniki, Greece
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- Doubek, M. (författare)
- University Hospital Brno, Brno, Czech Republic
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- Kättström, Magdalena, 1974- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Medicine, Faculty of Medicine and Health, Örebro University, Örebro, Sweden
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- Giannopoulos, K. (författare)
- Medical University of Lublin, Lublin, Poland
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- Simkovic, M. (författare)
- 4th Department of Internal Medicine - Haematology, Faculty of Medicine in Hradec Králové, University Hospital and Charles University in Prague, Hradec Kralove, Czech Republic
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- Moreno, C. (författare)
- Hospital de la Santa Creu I Sant Pau, Josep Carreras Leukaemia Research Institute, Barcelona, Spain
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- Massaia, M. (författare)
- AO S.Croce e Carle, Cuneo, Italy; Turin University, Turin, Italy
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- Bumbea, H. (författare)
- University Emergency Hospital, Bucharest, Romania; University of Medicine and Pharmacy, Carol Davila, Bucharest, Romania
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- Alshemmari, S. (författare)
- Department of Medicine, Faculty of Medicine, Kuwait University, Safat, Kuwait
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- Ranghetti, P. (författare)
- IRCCS San Raffaele Hospital, Milan, Italy
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- Perotta, E. (författare)
- IRCCS San Raffaele Hospital, Milan, Italy
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- Martini, F. (författare)
- IRCCS San Raffaele Hospital, Milan, Italy
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- Sant'Antonio, E. (författare)
- IRCCS San Raffaele Hospital, Milan, Italy
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- Colia, M. (författare)
- IRCCS San Raffaele Hospital, Milan, Italy
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- Combi, C. (författare)
- IRCCS San Raffaele Hospital, Milan, Italy
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- Levi, S. (författare)
- Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
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- Kater, A. P. (författare)
- Amsterdam UMC, Amsterdam, The Netherlands
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- Hazenberg, M. (författare)
- Amsterdam UMC, Amsterdam, The Netherlands
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- Nijhof, I. S. (författare)
- Amsterdam UMC, Amsterdam, The Netherlands; St Antonius Hospital, Nieuwegein, The Netherlands
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- Hofsink, Q. (författare)
- Amsterdam UMC, Amsterdam, The Netherlands
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- Demosthenous, C. (författare)
- Centre for Research and Technology Hellas, Thessaloniki, Greece; Hematology Department and HCT Unit, G. Papanicolaou Hospital, Thessaloniki, Greece
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- Kotaskova, J. (författare)
- University Hospital Brno, Brno, Czech Republic; Central European Institute of Technology, Masaryk University, Brno, Czech Republic
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- Zaleska, J. (författare)
- Medical University of Lublin, Lublin, Poland
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- Vrbacky, F. (författare)
- 4th Department of Internal Medicine - Haematology, Faculty of Medicine in Hradec Králové, University Hospital and Charles University in Prague, Hradec Kralove, Czech Republic
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- Raya, A. Mora (författare)
- Hospital de la Santa Creu I Sant Pau, Josep Carreras Leukaemia Research Institute, Barcelona, Spain
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- Bisogno, D. (författare)
- AO S.Croce e Carle, Cuneo, Italy
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- Tripoli, I. E. (författare)
- AO S.Croce e Carle, Cuneo, Italy; Turin University, Turin, Italy
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- Popov, V. M. (författare)
- Colentina Clinical Hospital, Bucharest, Romania
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- Roman, V. (författare)
- Center of Immunology Department, Stefan S. Nicolau Institute of Virology, Bucharest, Romania
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- Stavroyianni, N. (författare)
- Hematology Department and HCT Unit, G. Papanicolaou Hospital, Thessaloniki, Greece
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- Karypidou, M. (författare)
- Centre for Research and Technology Hellas, Thessaloniki, Greece
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- Scarano, E. (författare)
- IRCCS San Raffaele Hospital, Milan, Italy
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- Locatelli, M. (författare)
- Laboratory Medicine Service, IRCCS San Raffaele Hospital, Milano, Italy
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- Frenquelli, M. (författare)
- IRCCS San Raffaele Hospital, Milan, Italy
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- Scarfò, L. (författare)
- Vita Salute San Raffaele University, Milan, Italy; IRCCS San Raffaele Hospital, Milan, Italy
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- Stamatopoulos, K. (författare)
- Centre for Research and Technology Hellas, Thessaloniki, Greece
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- Ghia, P. (författare)
- Vita Salute San Raffaele University, Milan, Italy; IRCCS San Raffaele Hospital, Milan, Italy
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(creator_code:org_t)
- John Wiley & Sons, 2024
- 2024
- Engelska.
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Ingår i: American Journal of Hematology. - : John Wiley & Sons. - 0361-8609 .- 1096-8652. ; 99:4, s. 745-750
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Profound immune dysregulation and impaired response to the SARS-CoV-2 vaccine put patients with chronic lymphocytic leukemia (CLL) at risk of severe COVID-19. We compared humoral memory and T-cell responses after booster dose vaccination or breakthrough infection. (Green) Quantitative determination of anti-Spike specific antibodies. Booster doses increased seroconversion rate and antibody titers in all patient categories, ultimately generating humoral responses similar to those observed in the postinfection cohort. In detail, humoral response with overscale median antibody titers arose in >80% of patients in watch and wait, off-therapy in remission, or under treatment with venetoclax single-agent. Anti-CD20 antibodies and active treatment with BTK inhibitors (BTKi) represent limiting factors of humoral response, still memory mounted in ~40% of cases following booster doses or infection. (Blue) Evaluation of SARS-CoV-2-specific T-cell responses. Number of T-cell functional activation markers documented in each patient. The vast majority of patients, including those seronegative, developed T-cell responses, qualitatively similar between treatment groups or between vaccination alone and infection cases. These data highlight the efficacy of booster doses in eliciting T-cell immunity independently of treatment status and support the use of additional vaccination boosters to stimulate humoral immunity in patients on active CLL-directed treatments.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
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Till lärosätets databas
- Av författaren/redakt...
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Campanella, A.
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Capasso, A.
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Heltai, S.
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Taccetti, C.
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Albi, E.
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Herishanu, Y.
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visa fler...
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Haggenburg, S.
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Chatzikonstantin ...
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Doubek, M.
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Kättström, Magda ...
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Giannopoulos, K.
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Simkovic, M.
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Moreno, C.
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Massaia, M.
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Bumbea, H.
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Alshemmari, S.
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Ranghetti, P.
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Perotta, E.
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Martini, F.
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Sant'Antonio, E.
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Colia, M.
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Combi, C.
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Levi, S.
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Kater, A. P.
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Hazenberg, M.
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Nijhof, I. S.
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Hofsink, Q.
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Demosthenous, C.
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Kotaskova, J.
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Zaleska, J.
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Vrbacky, F.
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Raya, A. Mora
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Bisogno, D.
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Tripoli, I. E.
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Popov, V. M.
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Roman, V.
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Stavroyianni, N.
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Karypidou, M.
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Scarano, E.
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Locatelli, M.
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Frenquelli, M.
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Scarfò, L.
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Stamatopoulos, K ...
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Ghia, P.
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- MEDICIN OCH HÄLSOVETENSKAP
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Örebro universitet