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- Battiston, R., et al.
(författare)
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High precision particle astrophysics as a new window on the universe with an Antimatter Large Acceptance Detector In Orbit (ALADInO)
- 2021
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Ingår i: Experimental astronomy. - : Springer Science and Business Media B.V.. - 0922-6435 .- 1572-9508. ; 51:3, s. 1299-1330
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Tidskriftsartikel (refereegranskat)abstract
- Multimessenger astrophysics is based on the detection, with the highest possible accuracy, of the cosmic radiation. During the last 20 years, the advent space-borne magnetic spectrometers in space (AMS-01, Pamela, AMS-02), able to measure the charged cosmic radiation separating matter from antimatter, and to provide accurate measurement of the rarest components of Cosmic Rays (CRs) to the highest possible energies, have become possible, together with the ultra-precise measurement of ordinary CRs. These developments started the era of precision Cosmic Ray physics providing access to a rich program of high-energy astrophysics addressing fundamental questions like matter-antimatter asymmetry, indirect detection for Dark Matter and the detailed study of origin, acceleration and propagation of CRs and their interactions with the interstellar medium. In this paper we address the above-mentioned scientific questions, in the context of a second generation, large acceptance, superconducting magnetic spectrometer proposed as mission in the context of the European Space Agency’s Voyage2050 long-term plan: the Antimatter Large Acceptance Detector In Orbit (ALADInO) would extend by about two orders of magnitude in energy and flux sensitivity the separation between charged particles/anti-particles, making it uniquely suited for addressing and potentially solving some of the most puzzling issues of modern cosmology.
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- Quitoras, M. R., et al.
(författare)
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Towards robust investment decisions and policies in integrated energy systems planning : Evaluating trade-offs and risk hedging strategies for remote communities
- 2021
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Ingår i: Energy Conversion and Management. - : Elsevier Ltd. - 0196-8904 .- 1879-2227. ; 229
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Tidskriftsartikel (refereegranskat)abstract
- Policy and investment decisions in developing clean energy strategies for remote communities are subject to multiple uncertainties that impact overall strategy outcomes, including those related to environmental emissions and energy costs. In this context, robust modeling approaches are required that can clarify potential outcomes while subject to such uncertainties. This work introduces a novel modeling framework that enables enhanced decision making in energy systems planning for remote communities, which for the first time takes into account context-specific decision-maker attitudes towards multiple inter-related uncertainties and various energy solution philosophies. In particular, multiple energy system configurations are evaluated by simultaneously minimizing the levelised cost of energy and fuel consumption, with a test case for a specific community in the Northwest Territories, Canada. The concept of model robustness and validity together with the stochastic nature of uncertain parameters are combined in a multi-objective optimization framework that elucidates the full spectrum of energy solutions available in such a remote Arctic context. Introducing known uncertainties in renewable energy characteristics was found to reduce overall energy yields from the renewable energy technologies. Specifically, the deterministic renewable energy penetration of 69% from a specific energy system configuration reduced to a mean of 51% after the inclusion of uncertainties via probabilistic simulation. Conversely, diesel fuel consumption increased to 750,000 L/yr (mean) from its initial deterministic value of 447,470 L/yr. Holistic energy solutions which include both supply and demand-side considerations are also analyzed. Specifically, a reduced community domestic heating load of 40% was achieved via retrofit of high performance building fabric enclosures evaluated in conjunction with renewable energy supply options. Ultimately, insights and real-world applications have been synthesized to provide coherent recommendations on strategies to address energy security, energy affordability and environmental sustainability, along with meaningful propositions towards Indigenous community-led energy projects in a range of contexts.
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- Gul, E., et al.
(författare)
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Perspectives and state of the art in producing solar fuels and chemicals from CO2
- 2021
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Ingår i: Advanced Technology for the Conversion of Waste into Fuels and Chemicals: Volume 2: Chemical Processes. - : Elsevier. - 9780323901505 ; , s. 181-219
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- Solar Fuels and chemicals from CO2 can be produced through two main reactions: one is CO2 photoreduction, using different catalysts and different reducing agents; the other is CO2 fixation, which is usually performed through natural photosynthesis. The research nowadays is directed on the production of fuels and chemicals with one or two atoms of carbon, for example CH4, CO, HCOOH, HCHO, CH3OH, C2H5OH, etc. The chapter aims at comparing natural photosynthesis processes and reactions with artificial photosynthesis. After taking into consideration the natural photosynthetic process, the chapter focuses on heterogeneous and homogeneous photocatalysis. Heterogeneous catalysis can be performed with semiconductors and powder catalysts. Special attention is given to TiO2 as a promising photocatalyst. Homogeneous photocatalysts are usually represented by molecular catalysts, which are dissolved in water or another solvent. Usually, homogeneous photocatalysis is performed in complex systems which are composed by: a light harvesting unit (LHU) (i.e. the photosensitizer); one catalytic site for the oxidation process, where the electrons are supplied by a sacrificial donor; one reduction site, where the electrons are transmitted to CO2. Finally, even more complex systems are represented by those based on photoelectrocatalysis. These have the main advantage to separate the oxidation and reduction reactions at the two different electrodes of the system. In principle photoelectrochemical cells can be a way to mimic artificially the working principle of natural photosynthesis.
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- Ul Mushtaq, Ameeq, et al.
(författare)
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Neutron reflectometry and NMR spectroscopy of full-length Bcl-2 protein reveal its membrane localization and conformation
- 2021
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Ingår i: Communications Biology. - : Springer Science and Business Media LLC. - 2399-3642. ; 4:1
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Tidskriftsartikel (refereegranskat)abstract
- B-cell lymphoma 2 (Bcl-2) proteins are the main regulators of mitochondrial apoptosis. Anti-apoptotic Bcl-2 proteins possess a hydrophobic tail-anchor enabling them to translocate to their target membrane and to shift into an active conformation where they inhibit pro-apoptotic Bcl-2 proteins to ensure cell survival. To address the unknown molecular basis of their cell-protecting functionality, we used intact human Bcl-2 protein natively residing at the mitochondrial outer membrane and applied neutron reflectometry and NMR spectroscopy. Here we show that the active full-length protein is entirely buried into its target membrane except for the regulatory flexible loop domain (FLD), which stretches into the aqueous exterior. The membrane location of Bcl-2 and its conformational state seems to be important for its cell-protecting activity, often infamously upregulated in cancers. Most likely, this situation enables the Bcl-2 protein to sequester pro-apoptotic Bcl-2 proteins at the membrane level while sensing cytosolic regulative signals via its FLD region. Through neutron reflectometry and NMR spectroscopy studies, Mushtaq et al study the full-length Bcl-2 protein reconstituted in lipid bilayers. They find that, in contrast to previously studied truncated, soluble protein versions, intact Bcl-2 is mainly embedded in the membrane with its regulatory loop highly flexible.
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