| 1. |
- Carroll, R. J., et al.
(författare)
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Blurring the Boundaries : Decays of Multiparticle Isomers at the Proton Drip Line
- 2014
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Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 112:9, s. 092501-
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Tidskriftsartikel (refereegranskat)abstract
- A multiparticle spin-trap isomer has been discovered in the proton-unbound nucleus 158 73 Ta 85. The isomer mainly decays by (h) over bar -ray emission with a half-life of 6.1d(1) mu s. Analysis of the gamma-ray data shows that the isomer lies 2668 keV above the known 9(+) state and has a spin 10h higher and negative parity. This 19(-) isomer also has an 8644(11) keV, 1.4(2)% alpha-decay branch that populates the 9(+) state in Lu-154. No proton-decay branch from the isomer was identified, despite the isomer being unbound to proton emission by 3261(14) keV. This remarkable stability against proton emission is compared with theoretical predictions, and the implications for the extent of observable nuclides are considered.
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| 2. |
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| 3. |
- Hadinia, B., et al.
(författare)
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IN-BEAM gamma-RAY SPECTROSCOPY ABOVE THE HIGH-SPIN ISOMERIC STATE IN Lu-155
- 2013
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Ingår i: CAPTURE GAMMA-RAY SPECTROSCOPY AND RELATED TOPICS. - : WORLD SCIENTIFIC PUBL CO PTE LTD. ; , s. 139-144
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Konferensbidrag (refereegranskat)abstract
- Excited states in Lu-155 have been studied at the Accelerator Laboratory of the University of Jyvaskyla in Finland. The Lu-155 nuclei were populated using the reaction of Ni-58 on (102)pd at a beam energy of 280 MeV. The nuclei of interest were selected using the RITU gas filled recoil separator and the prompt gamma rays belonging to 155Lu were identified using the recoil-decay tagging technique. The gamma-ray transitions de-exciting the excited states above the high-spin isomeric a-decaying state in Lu-155 have been identified. A gamma-ray coincidence analysis shows that the previously reported level scheme for Lu-155 should be revised.
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| 4. |
- Tammiste, A, et al.
(författare)
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Whole-exome sequencing identifies a polymorphism in the BMP5 gene associated with SSRI treatment response in major depression
- 2013
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Ingår i: Journal of psychopharmacology (Oxford, England). - : SAGE Publications. - 1461-7285 .- 0269-8811. ; 27:10, s. 915-920
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Tidskriftsartikel (refereegranskat)abstract
- Although antidepressants are widely used in the pharmacotherapy of major depressive disorder (MDD), their efficacy is still insufficient as approximately one-third of the patients do not fully recover even after several treatment trials. Inter-individual genetic differences are thought to contribute to the variability in antidepressant response; however, current findings from pharmacogenetic studies are uncertain or not clearly replicated. Here we report the first application of full exome sequencing for the analysis of pharmacogenomics on antidepressant treatment. After 12 weeks of treatment with the selective serotonin re-uptake inhibitor escitalopram, we selected five clear responders and five clear non-responders for exome sequencing. By comparing the allele counts of previously known single nucleotide polymorphisms and novel polymorphisms we selected 38 markers for further genotyping in two independent patient samples treated with escitalopram ( n=116 and n=394). The A allele, carried by approximately 30% of the patients with MDD, of rs41271330 in the bone morphogenetic protein (BMP5) gene showed strong association with worse treatment response in both sample sets ( p=0.001), indicating that this is an promising pharmacogenetic marker for prediction of antidepressant therapeutic outcome.
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| 8. |
- Brenner, C. M., et al.
(författare)
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Dependence of laser accelerated protons on laser energy following the interaction of defocused, intense laser pulses with ultra-thin targets
- 2011
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Ingår i: Laser and Particle Beams. - 0263-0346. ; 29:3, s. 345-351
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Tidskriftsartikel (refereegranskat)abstract
- The scaling of the flux and maximum energy of laser-driven sheath-accelerated protons has been investigated as a function of laser pulse energy in the range of 15-380 mJ at intensities of 10(16)-10(18) W/cm(2). The pulse duration and target thickness were fixed at 40 fs and 25 nm, respectively, while the laser focal spot size and drive energy were varied. Our results indicate that while the maximum proton energy is dependent on the laser energy and laser spot diameter, the proton flux is primarily related to the laser pulse energy under the conditions studied here. Our measurements show that increasing the laser energy by an order of magnitude results in a more than 500-fold increase in the observed proton flux. Whereas, an order of magnitude increase in the laser intensity generated by decreasing the laser focal spot size, at constant laser energy, gives rise to less than a tenfold increase in observed proton flux.
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| 9. |
- Carroll, R. K., et al.
(författare)
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Identification of an intracellular M17 family leucine aminopeptidase that is required for virulence in Staphylococcus aureus
- 2012
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Ingår i: Microbes and Infection. - : Elsevier BV. - 1286-4579. ; 14:11, s. 989-999
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Tidskriftsartikel (refereegranskat)abstract
- Staphylococcus aureus is a highly virulent bacterial pathogen capable of causing a variety of ailments throughout the human body. It is a major public health concern due to the continued emergence of highly pathogenic methicillin resistant strains (MRSA) both within hospitals and in the community. Virulence in S. aureus is mediated by an array of secreted and cell wall associated virulence factors, including toxins, hemolysins and proteases. In this work we identify a (l) under bar eucine (a) under bar mino (p) under bar eptidase (LAP, pepZ) that strongly impacts the pathogenic abilities of S. aureus. Disruption of the pepZ gene in either Newman or USA300 resulted in a dramatic attenuation of virulence in both localized and systemic models of infection. LAP is required for survival inside human macrophages and gene expression analysis shows that pepZ expression is highest in the intracellular environment. We examine the cellular location of LAP and demonstrate that it is localized to the bacterial cytosol. These results identify for the first time an intracellular leucine aminopeptidase that influences disease causation in a Gram-positive bacterium. (C) 2012 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.
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| 10. |
- Coury, M., et al.
(författare)
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Influence of laser irradiated spot size on energetic electron injection and proton acceleration in foil targets
- 2012
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Ingår i: Applied Physics Letters. - : AIP Publishing. - 0003-6951 .- 1077-3118. ; 100:7
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Tidskriftsartikel (refereegranskat)abstract
- The influence of irradiated spot size on laser energy coupling to electrons, and subsequently to protons, in the interaction of intense laser pulses with foil targets is investigated experimentally. Proton acceleration is characterized for laser intensities ranging from 2 x 10(18) - 6 x 10(20) W/cm(2), by (1) variation of the laser energy for a fixed irradiated spot size, and (2) by variation of the spot size for a fixed energy. At a given laser pulse intensity, the maximum proton energy is higher under defocus illumination compared to tight focus and the results are explained in terms of geometrical changes to the hot electron injection. (C) 2012 American Institute of Physics. [doi:10.1063/1.3685615]
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