| 1. |
- Harrison, C. J., et al.
(författare)
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An international study of intrachromosomal amplification of chromosome 21 (iAMP21) : cytogenetic characterization and outcome
- 2014
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Ingår i: Leukemia. - : Springer Science and Business Media LLC. - 0887-6924 .- 1476-5551. ; 28:5, s. 1015-1021
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Tidskriftsartikel (refereegranskat)abstract
- Intrachromosomal amplification of chromosome 21 (iAMP21) defines a distinct cytogenetic subgroup of childhood B-cell precursor acute lymphoblastic leukaemia (BCP-ALL). To date, fluorescence in situ hybridisation (FISH), with probes specific for the RUNX1 gene, provides the only reliable detection method (five or more RUNX1 signals per cell). Patients with iAMP21 are older (median age 9 years) with a low white cell count. Previously, we demonstrated a high relapse risk when these patients were treated as standard risk. Recent studies have shown improved outcome on intensive therapy. In view of these treatment implications, accurate identification is essential. Here we have studied the cytogenetics and outcome of 530 iAMP21 patients that highlighted the association of specific secondary chromosomal and genetic changes with iAMP21 to assist in diagnosis, including the gain of chromosome X, loss or deletion of chromosome 7, ETV6 and RB1 deletions. These iAMP21 patients when treated as high risk showed the same improved outcome as those in trial-based studies regardless of the backbone chemotherapy regimen given. This study reinforces the importance of intensified treatment to reduce the risk of relapse in iAMP21 patients. This now well-defined patient subgroup should be recognised by World Health Organisation (WHO) as a distinct entity of BCP-ALL.
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| 2. |
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| 3. |
- Cazzaniga, C., et al.
(författare)
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First measurement of the VESUVIO neutron spectrum in the 30-80 MeV energy range using a Proton Recoil Telescope technique
- 2013
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Ingår i: Journal of Instrumentation. - 1748-0221 .- 1748-0221. ; 8, s. P11008-
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Tidskriftsartikel (refereegranskat)abstract
- Measurements of the fast neutron energy spectrum at the ISIS spallation source are reported. The measurements were performed with a Proton Recoil Telescope consisting of a thin plastic foil placed in the neutron beam and two scintillator detectors. Results in the neutron energy range 30 MeV < E-n < 80 MeV are in good agreement with Monte Carlo simulations of the neutron spectrum.
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| 4. |
- Cazzaniga, C., et al.
(författare)
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Single crystal diamond detector measurements of deuterium-deuterium and deuterium-tritium neutrons in Joint European Torus fusion plasmas
- 2014
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Ingår i: Review of Scientific Instruments. - : AIP Publishing. - 0034-6748 .- 1089-7623. ; 85:4, s. 043506-
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Tidskriftsartikel (refereegranskat)abstract
- First simultaneous measurements of deuterium-deuterium (DD) and deuterium-tritium neutrons from deuterium plasmas using a Single crystal Diamond Detector are presented in this paper. The measurements were performed at JET with a dedicated electronic chain that combined high count rate capabilities and high energy resolution. The deposited energy spectrum from DD neutrons was successfully reproduced by means of Monte Carlo calculations of the detector response function and simulations of neutron emission from the plasma, including background contributions. The reported results are of relevance for the development of compact neutron detectors with spectroscopy capabilities for installation in camera systems of present and future high power fusion experiments.
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| 5. |
- Cazzaniga, C., et al.
(författare)
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Thin YAP:Ce and LaBr3:Ce scintillators as proton detectors of a thin-film proton recoil neutron spectrometer for fusion and spallation sources applications
- 2014
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Ingår i: Nuclear Instruments and Methods in Physics Research Section A. - : Elsevier BV. - 0168-9002 .- 1872-9576. ; 751, s. 19-22
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Tidskriftsartikel (refereegranskat)abstract
- Two thin inorganic scintillators based on YAP and LaBr3 crystals (1 in, diameter x 0.1 in, height) have been used for proton measurements at the Uppsala tandem accelerator in the energy range 4-8 MeV. Measurements show a comparable good energy resolution for the two detectors, better than 2% (FWHM) for 8 MeV protons, which compares to 3.8% (LaBr3) and 3.7% (YAP) obtained at the 1.3 MeV peak of a Co-60 gamma-ray source. The main advantages of these crystals are a fast scintillation time (less than 30 ns), an excellent light yield and the capability to operate in large neutron background, which make them ideal candidates as proton detectors of a thin-film proton recoil neutron spectrometer for application on fusion experiments and fast neutron spallation sources.
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| 6. |
- Santambrogio, M. D., et al.
(författare)
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Smart technologies for effective reconfiguration: The FASTER approach
- 2012
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Ingår i: ReCoSoC 2012 - 7th International Workshop on Reconfigurable and Communication-Centric Systems-on-Chip, Proceedings. - 9781467325721
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Konferensbidrag (refereegranskat)abstract
- Current and future computing systems increasingly require that their functionality stays flexible after the system is operational, in order to cope with changing user requirements and improvements in system features, i.e. changing protocols and data-coding standards, evolving demands for support of different user applications, and newly emerging applications in communication, computing and consumer electronics. Therefore, extending the functionality and the lifetime of products requires the addition of new functionality to track and satisfy the customers needs and market and technology trends. Many contemporary products along with the software part incorporate hardware accelerators for reasons of performance and power efficiency. While adaptivity of software is straightforward, adaptation of the hardware to changing requirements constitutes a challenging problem requiring delicate solutions. The FASTER (Facilitating Analysis and Synthesis Technologies for Effective Reconfiguration) project aims at introducing a complete methodology to allow designers to easily implement a system specification on a platform which includes a general purpose processor combined with multiple accelerators running on an FPGA, taking as input a high-level description and fully exploiting, both at design time and at run time, the capabilities of partial dynamic reconfiguration. The goal is that for selected application domains, the FASTER toolchain will be able to reduce the design and verification time of complex reconfigurable systems providing additional novel verification features that are not available in existing tool flows.
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