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Spirometric phenoty...
Spirometric phenotypes from early childhood to young adulthood : a Chronic Airway Disease Early Stratification study
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- Wang, Gang (författare)
- Karolinska Institutet
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- Hallberg, Jenny (författare)
- Karolinska Institutet
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- Charalampopoulos, Dimitrios (författare)
- MRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom
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- Sanahuja, Maribel Casas (författare)
- ISGlobal, Barcelona, Spain; Universitat Pompeu Fabra, Barcelona, Spain; Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain
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- Breyer-Kohansal, Robab (författare)
- Ludwig Boltzmann Institute for Lung Health, Vienna, Austria
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- Langhammer, Arnulf (författare)
- Dept of Public Health and Nursing, Faculty of Medicine and Health Sciences, HUNT Research Centre, Norwegian University of Science and Technology (NTNU), Levanger, Norway
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- Granell, Raquel (författare)
- MRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom
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- Vonk, Judith M. (författare)
- Dept of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands; University Medical Center Groningen, Groningen Research Institute for Asthma and COPD, University of Groningen, Groningen, Netherlands
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- Mian, Annemiek (författare)
- The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands; Division of Respiratory Medicine and Allergology, and Neonatology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands
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- Olvera, Núria (författare)
- Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain; Institut d’investigacions biomediques August Pi I Sunyer, Barcelona, Spain
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- Laustsen, Lisbeth Mølgaard (författare)
- Dept of Public Health, Environment Occupation and Health, Danish Ramazzini Centre, Aarhus University, Aarhus, Denmark
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- Rönmark, Eva (författare)
- Umeå universitet,Avdelningen för hållbar hälsa
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- Abellan, Alicia (författare)
- Karolinska Institutet
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- Agusti, Alvar (författare)
- Institut d’investigacions biomediques August Pi I Sunyer, Barcelona, Spain; Respiratory Institute, Hospital Clinic, Univ. Barcelona, Barcelona, Spain; CIBERESP (ISCiii), Barcelona, Spain
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- Arshad, Syed Hasan (författare)
- David Hide Asthma and Allergy Research Centre, Newport, United Kingdom; NIHR Southampton Biomedical Research Centre, University Hospitals Southampton NHS Foundation Trust, Southampton, United Kingdom; Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom
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- Bergström, Anna (författare)
- Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Centre for Occupational and Environmental Medicine, Region Stockholm, Stockholm, Sweden
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- Boezen, H. Marike (författare)
- Dept of Epidemiology, University Medical Center Groningen, Groningen, Netherlands
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- Breyer, Marie-Kathrin (författare)
- Ludwig Boltzmann Institute for Lung Health, Vienna, Austria
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- Burghuber, Otto (författare)
- Ludwig Boltzmann Institute for Lung Health, Vienna, Austria; Faculty of Medicine, Sigmund Freud University, Vienna, Austria
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- Bolund, Anneli Clea (författare)
- Dept of Public Health, Environment Occupation and Health, Danish Ramazzini Centre, Aarhus University, Aarhus, Denmark
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- Custovic, Adnan (författare)
- National Heart and Lung Institute, Imperial College London, London, United Kingdom
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- Devereux, Graham (författare)
- Liverpool School of Tropical Medicine, Liverpool, United Kingdom
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- Donaldson, Gavin C. (författare)
- National Heart and Lung Institute, Imperial College London, London, United Kingdom
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- Duijts, Liesbeth (författare)
- The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands; Division of Respiratory Medicine and Allergology, and Neonatology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands; Division of Neonatology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands
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- Esplugues, Ana (författare)
- Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain; Nursing Department, Faculty of Nursing and Chiropody, Universitat de València, Valencia, Spain; Epidemiology and Environmental Health Joint Research Unit, FISABIO−Universitat Jaume I−Universitat de València, Valencia, Spain
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- Faner, Rosa (författare)
- Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain
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- Ballester, Ferran (författare)
- Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain; Nursing Department, Faculty of Nursing and Chiropody, Universitat de València, Valencia, Spain; Epidemiology and Environmental Health Joint Research Unit, FISABIO−Universitat Jaume I−Universitat de València, Valencia, Spain
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- Garcia-Aymerich, Judith (författare)
- ISGlobal, Barcelona, Spain; Universitat Pompeu Fabra, Barcelona, Spain; Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain
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- Gehring, Ulrike (författare)
- Institute for Risk Assessment Sciences, Utrecht University, Utrecht, Netherlands
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- Haider, Sadia (författare)
- National Heart and Lung Institute, Imperial College London, London, United Kingdom
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- Hartl, Sylvia (författare)
- Ludwig Boltzmann Institute for Lung Health, Vienna, Austria; Faculty of Medicine, Sigmund Freud University, Vienna, Austria
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- Backman, Helena (författare)
- Umeå universitet,Avdelningen för hållbar hälsa
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- Holloway, John W. (författare)
- NIHR Southampton Biomedical Research Centre, University Hospitals Southampton NHS Foundation Trust, Southampton, United Kingdom; Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, United Kingdom
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- Koppelman, Gerard H. (författare)
- University Medical Center Groningen, Groningen Research Institute for Asthma and COPD, University of Groningen, Groningen, Netherlands; Dept of Pediatric Pulmonology and Pediatric Allergology, University Medical Center Groningen, Beatrix Children’s Hospital, University of Groningen, Groningen, Netherlands
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- Lertxundi, Aitana (författare)
- Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain; Dept of Preventive Medicine and Public Health, Faculty of Medicine, University of the Basque Country (UPV/EHU), Leioa, Spain; BIODONOSTIA Health Research Institute, Donostia-San Sebastian, Spain
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- Holmen, Turid Lingaas (författare)
- Dept of Public Health and General Practice, HUNT Research Center, NTNU, Levanger, Norway
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- Lowe, Lesley (författare)
- Division of Infection, Immunity and Respiratory Medicine, University of Manchester, Manchester Academic Health Science Centre, NIHR, Manchester, United Kingdom; Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester, United Kingdom
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- Mensink-Bout, Sara M. (författare)
- The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands
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- Murray, Clare S. (författare)
- Division of Infection, Immunity and Respiratory Medicine, University of Manchester, Manchester Academic Health Science Centre, NIHR, Manchester, United Kingdom; Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester, United Kingdom
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- Roberts, Graham (författare)
- David Hide Asthma and Allergy Research Centre, Newport, United Kingdom; NIHR Southampton Biomedical Research Centre, University Hospitals Southampton NHS Foundation Trust, Southampton, United Kingdom; Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, United Kingdom
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- Hedman, Linnea, 1979- (författare)
- Umeå universitet,Avdelningen för hållbar hälsa
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- Schlünssen, Vivi (författare)
- Dept of Public Health, Environment Occupation and Health, Danish Ramazzini Centre, Aarhus University, Aarhus, Denmark
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- Sigsgaard, Torben (författare)
- Dept of Public Health, Environment Occupation and Health, Danish Ramazzini Centre, Aarhus University, Aarhus, Denmark
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- Simpson, Angela (författare)
- Division of Infection, Immunity and Respiratory Medicine, University of Manchester, Manchester Academic Health Science Centre, NIHR, Manchester, United Kingdom; Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester, United Kingdom
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- Sunyer, Jordi (författare)
- ISGlobal, Barcelona, Spain; Universitat Pompeu Fabra, Barcelona, Spain; IMIM-Parc Salut Mar, Barcelona, Spain
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- Torrent, Maties (författare)
- ib-salut, Area de Salut de Menorca, Menorca, Spain
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- Turner, Stephen (författare)
- Royal Aberdeen Children’s Hospital NHS Grampian, Aberdeen, United Kingdom
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- Van den Berge, Maarten (författare)
- University Medical Center Groningen, Groningen Research Institute for Asthma and COPD, University of Groningen, Groningen, Netherlands; Dept of Pulmonary Diseases, University Medical Center Groningen, University of Groningen, Groningen, Netherlands
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- Vermeulen, Roel C.H. (författare)
- Institute for Risk Assessment Sciences, Utrecht University, Utrecht, Netherlands
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- Vikjord, Sigrid Anna Aalberg (författare)
- Dept of Public Health and Nursing, Faculty of Medicine and Health Sciences, HUNT Research Centre, Norwegian University of Science and Technology (NTNU), Levanger, Norway; Dept of Medicine and Rehabilitation, Levanger Hospital, Nord-Trøndelag Hospital Trust, Levanger, Norway
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- Wedzicha, Jadwiga A. (författare)
- National Heart and Lung Institute, Imperial College London, London, United Kingdom
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- van der Zee, Anke H. Maitland (författare)
- Dept of Respiratory Medicine, Amsterdam University Medical Centers (UMC), University of Amsterdam, Amsterdam, Netherlands; Pediatric Respiratory Medicine, Emma Children’s Hospital, Amsterdam UMC, Amsterdam, Netherlands
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- Melén, Erik (författare)
- Karolinska Institutet
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(creator_code:org_t)
- 2021-09-29
- 2021
- Engelska.
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Ingår i: ERJ Open Research. - : ERS Publications. - 2312-0541. ; 7:4
- Relaterad länk:
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://openres.ersj...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Background: The prevalences of obstructive and restrictive spirometric phenotypes, and their relation to early-life risk factors from childhood to young adulthood remain poorly understood. The aim was to explore these phenotypes and associations with well-known respiratory risk factors across ages and populations in European cohorts.Methods: We studied 49334 participants from 14 population-based cohorts in different age groups (⩽10, >10–15, >15–20, >20–25 years, and overall, 5–25 years). The obstructive phenotype was defined as forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC) z-score less than the lower limit of normal (LLN), whereas the restrictive phenotype was defined as FEV1/FVC z-score ⩾LLN, and FVC z-score Results: The prevalence of obstructive and restrictive phenotypes varied from 3.2–10.9% and 1.8–7.7%, respectively, without clear age trends. A diagnosis of asthma (adjusted odds ratio (aOR=2.55, 95% CI 2.14–3.04), preterm birth (aOR=1.84, 1.27–2.66), maternal smoking during pregnancy (aOR=1.16, 95% CI 1.01–1.35) and family history of asthma (aOR=1.44, 95% CI 1.25–1.66) were associated with a higher prevalence of obstructive, but not restrictive, phenotype across ages (5–25 years). A higher current body mass index (BMI was more often observed in those with the obstructive phenotype but less in those with the restrictive phenotype (aOR=1.05, 95% CI 1.03–1.06 and aOR=0.81, 95% CI 0.78–0.85, per kg·m−2 increase in BMI, respectively). Current smoking was associated with the obstructive phenotype in participants older than 10 years (aOR=1.24, 95% CI 1.05–1.46).Conclusion: Obstructive and restrictive phenotypes were found to be relatively prevalent during childhood, which supports the early origins concept. Several well-known respiratory risk factors were associated with the obstructive phenotype, whereas only low BMI was associated with the restrictive phenotype, suggesting different underlying pathobiology of these two phenotypes.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
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Wang, Gang
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Hallberg, Jenny
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Charalampopoulos ...
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Sanahuja, Maribe ...
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Breyer-Kohansal, ...
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Langhammer, Arnu ...
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visa fler...
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Granell, Raquel
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Vonk, Judith M.
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Mian, Annemiek
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Olvera, Núria
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Laustsen, Lisbet ...
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Rönmark, Eva
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Abellan, Alicia
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Agusti, Alvar
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Arshad, Syed Has ...
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Bergström, Anna
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Boezen, H. Marik ...
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Breyer, Marie-Ka ...
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Burghuber, Otto
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Bolund, Anneli C ...
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Custovic, Adnan
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Devereux, Graham
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Donaldson, Gavin ...
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Duijts, Liesbeth
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Esplugues, Ana
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Faner, Rosa
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Ballester, Ferra ...
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Garcia-Aymerich, ...
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Gehring, Ulrike
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Haider, Sadia
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Hartl, Sylvia
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Backman, Helena
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Holloway, John W ...
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Koppelman, Gerar ...
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Lertxundi, Aitan ...
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Holmen, Turid Li ...
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Lowe, Lesley
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Mensink-Bout, Sa ...
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Murray, Clare S.
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Roberts, Graham
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Hedman, Linnea, ...
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Schlünssen, Vivi
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Sigsgaard, Torbe ...
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Simpson, Angela
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Sunyer, Jordi
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Torrent, Maties
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Turner, Stephen
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Van den Berge, M ...
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Vermeulen, Roel ...
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Vikjord, Sigrid ...
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Wedzicha, Jadwig ...
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van der Zee, Ank ...
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Melén, Erik
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Hälsovetenskap
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och Folkhälsovetensk ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Lungmedicin och ...
- Artiklar i publikationen
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ERJ Open Researc ...
- Av lärosätet
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Umeå universitet
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Karolinska Institutet