| 1. |
- Ding, Z., et al.
(författare)
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Effect of edge passivated by hydrogen on the transport properties of finite- size metallic carbon nanotube-based molecular devices
- 2012
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Ingår i: Advances in Nanodevices and Nanofabrication. - : Pan Stanford Publishing. - 9789814364546 - 9780429100383 ; , s. 153-161
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Bokkapitel (refereegranskat)abstract
- In this chapter, the effect of edge passivated by hydrogen on the electronic and transport properties of the molecular devices of finite-size metallic carbon nanotubes (CNTs) is investigated by using density-functional theory in combination with Green's function method. Three types of hydrogenations are considered for the edge carbon atoms at the two open ends of the CNTs. The calculated energy gap between the highest occupied and the lowest unoccupied molecular orbitals decreases with increasing the length of the CNTs for the three hydrogen-passivated cases, respectively. Nonlinear current-voltage (I-V) curves and quantum conductance have been obtained in all junctions. It is shown that the electronic properties of the finite-size CNTs and the transport properties are sensitive to the passivation types of edge. With increasing the hydrogen passivation concentration of edge carbon atoms, it is indicated that the I-V characteristics have obviously the widening of bandgap and the decreasing of the quantum conductance.
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| 2. |
- Chen, Guo, 1969, et al.
(författare)
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Glassy Dynamics of Proteins
- 2012
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Ingår i: Structural Glasses and Supercooled Liquids: Theory, Experiment, and Applications. - : Wiley. - 9780470452233 ; , s. 319-339
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 3. |
- Mackinnon, Alison, et al.
(författare)
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Design, synthesis, And applications of galectin modulators in human health
- 2014
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Ingår i: Carbohydrates as Drugs. - Cham : Springer International Publishing. - 1862-247X .- 1862-2461. - 9783319086743 - 9783319345376 - 9783319086750 ; , s. 95-122
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Bokkapitel (refereegranskat)abstract
- Over the last decade, the family of galectin proteins has been identified as key regulators of important biological processes. They bind β-D-galactopyranoside residues in glycoconjugates, and by presenting multiple binding sites, within one galectin or by forming dimers or multimers, they can cross-link glycoproteins and form galectin-glycoprotein lattices. Such lattices formed on the cell surface or in vesicles have been shown to control, for example, surface residence time and signaling by receptors. Hence, compounds modulating galectin binding to their glycoprotein ligands are of potential clinical interest. This chapter describes the design and development of disubstituted thiodigalactoside derivatives that form optimal interactions with the galectin-3 binding site resulting in double-digit nanomolar affinities. Studies are discussed in which such galectin-3-modulating compounds have been important in elucidating galectin-3 mechanisms, including galectin-3 trafficking, cancer, inflammation, fibrosis, and angiogenesis. Medically relevant models using the galectin-3 modulators in characterizing macrophage alternative activation and chronic inflammation, myofibroblast activation and fibrosis, and ocular angiogenesis are discussed in more detail. In summary, the high galectin-3 affinity and definitive effects in relevant models of the disubstituted thiodigalactosides identify them as promising as lead compounds for drug development, albeit leaving a challenge in terms of optimizing PK/ADME properties.
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| 4. |
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