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Genome-wide meta-an...
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci
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Franke, Andre (author)
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McGovern, Dermot P B (author)
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Barrett, Jeffrey C (author)
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show more...
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Wang, Kai (author)
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Radford-Smith, Graham L (author)
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Ahmad, Tariq (author)
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Lees, Charlie W (author)
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Balschun, Tobias (author)
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Lee, James (author)
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Roberts, Rebecca (author)
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Anderson, Carl A (author)
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Bis, Joshua C (author)
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Bumpstead, Suzanne (author)
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Ellinghaus, David (author)
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Festen, Eleonora M (author)
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Georges, Michel (author)
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Green, Todd (author)
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Haritunians, Talin (author)
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Jostins, Luke (author)
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Latiano, Anna (author)
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Mathew, Christopher G (author)
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Montgomery, Grant W (author)
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Prescott, Natalie J (author)
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Raychaudhuri, Soumya (author)
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Rotter, Jerome I (author)
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Schumm, Philip (author)
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Sharma, Yashoda (author)
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Simms, Lisa A (author)
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Taylor, Kent D (author)
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Whiteman, David (author)
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Wijmenga, Cisca (author)
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Baldassano, Robert N (author)
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Barclay, Murray (author)
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Bayless, Theodore M (author)
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Brand, Stephan (author)
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Büning, Carsten (author)
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Cohen, Albert (author)
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Colombel, Jean-Frederick (author)
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Cottone, Mario (author)
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Stronati, Laura (author)
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Denson, Ted (author)
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De Vos, Martine (author)
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D'Inca, Renata (author)
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- Dubinsky, Marla (author)
- Karolinska Institutet
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Edwards, Cathryn (author)
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Florin, Tim (author)
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Franchimont, Denis (author)
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Gearry, Richard (author)
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Glas, Jürgen (author)
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Van Gossum, Andre (author)
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Guthery, Stephen L (author)
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- Halfvarson, Jonas, 1970- (author)
- Örebro universitet,Hälsoakademin
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Verspaget, Hein W (author)
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Hugot, Jean-Pierre (author)
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Karban, Amir (author)
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Laukens, Debby (author)
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Lawrance, Ian (author)
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Lemann, Marc (author)
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Levine, Arie (author)
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Libioulle, Cecile (author)
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Louis, Edouard (author)
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Mowat, Craig (author)
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Newman, William (author)
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Panés, Julián (author)
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Phillips, Anne (author)
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Proctor, Deborah D (author)
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Regueiro, Miguel (author)
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Russell, Richard (author)
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Rutgeerts, Paul (author)
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Sanderson, Jeremy (author)
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Sans, Miquel (author)
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Seibold, Frank (author)
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Steinhart, A Hillary (author)
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Stokkers, Pieter C F (author)
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- Torkvist, Leif (author)
- Karolinska Institutet
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Kullak-Ublick, Gerd (author)
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Wilson, David (author)
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Walters, Thomas (author)
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Targan, Stephan R (author)
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Brant, Steven R (author)
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Rioux, John D (author)
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D'Amato, Mauro (author)
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Weersma, Rinse K (author)
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Kugathasan, Subra (author)
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Griffiths, Anne M (author)
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Mansfield, John C (author)
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Vermeire, Severine (author)
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Duerr, Richard H (author)
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Silverberg, Mark S (author)
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Satsangi, Jack (author)
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Schreiber, Stefan (author)
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Cho, Judy H (author)
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Annese, Vito (author)
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Hakonarson, Hakon (author)
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Daly, Mark J (author)
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Parkes, Miles (author)
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(creator_code:org_t)
- 2010-11-21
- 2010
- English.
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In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 42:12, s. 1118-1125
- Related links:
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https://europepmc.or...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Subject headings
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- We undertook a meta-analysis of six Crohn's disease genome-wide association studies (GWAS) comprising 6,333 affected individuals (cases) and 15,056 controls and followed up the top association signals in 15,694 cases, 14,026 controls and 414 parent-offspring trios. We identified 30 new susceptibility loci meeting genome-wide significance (P < 5 × 10⁻⁸). A series of in silico analyses highlighted particular genes within these loci and, together with manual curation, implicated functionally interesting candidate genes including SMAD3, ERAP2, IL10, IL2RA, TYK2, FUT2, DNMT3A, DENND1B, BACH2 and TAGAP. Combined with previously confirmed loci, these results identify 71 distinct loci with genome-wide significant evidence for association with Crohn's disease.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Keyword
- Medicine
- Medicin
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Franke, Andre
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McGovern, Dermot ...
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Barrett, Jeffrey ...
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Wang, Kai
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Radford-Smith, G ...
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Ahmad, Tariq
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show more...
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Lees, Charlie W
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Balschun, Tobias
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Lee, James
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Roberts, Rebecca
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Anderson, Carl A
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Bis, Joshua C
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Bumpstead, Suzan ...
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Ellinghaus, Davi ...
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Festen, Eleonora ...
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Georges, Michel
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Green, Todd
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Haritunians, Tal ...
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Jostins, Luke
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Latiano, Anna
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Mathew, Christop ...
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Montgomery, Gran ...
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Prescott, Natali ...
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Raychaudhuri, So ...
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Rotter, Jerome I
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Schumm, Philip
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Sharma, Yashoda
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Simms, Lisa A
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Taylor, Kent D
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Whiteman, David
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Wijmenga, Cisca
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Baldassano, Robe ...
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Barclay, Murray
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Bayless, Theodor ...
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Brand, Stephan
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Büning, Carsten
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Cohen, Albert
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Colombel, Jean-F ...
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Cottone, Mario
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Stronati, Laura
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Denson, Ted
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De Vos, Martine
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D'Inca, Renata
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Dubinsky, Marla
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Edwards, Cathryn
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Florin, Tim
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Franchimont, Den ...
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Gearry, Richard
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Glas, Jürgen
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Van Gossum, Andr ...
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Guthery, Stephen ...
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Halfvarson, Jona ...
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Verspaget, Hein ...
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Hugot, Jean-Pier ...
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Karban, Amir
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Laukens, Debby
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Lawrance, Ian
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Lemann, Marc
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Levine, Arie
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Libioulle, Cecil ...
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Louis, Edouard
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Mowat, Craig
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Newman, William
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Panés, Julián
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Phillips, Anne
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Proctor, Deborah ...
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Regueiro, Miguel
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Russell, Richard
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Rutgeerts, Paul
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Sanderson, Jerem ...
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Sans, Miquel
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Seibold, Frank
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Steinhart, A Hil ...
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Stokkers, Pieter ...
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Torkvist, Leif
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Kullak-Ublick, G ...
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Wilson, David
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Walters, Thomas
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Targan, Stephan ...
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Brant, Steven R
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Rioux, John D
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D'Amato, Mauro
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Weersma, Rinse K
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Kugathasan, Subr ...
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Griffiths, Anne ...
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Mansfield, John ...
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Vermeire, Severi ...
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Duerr, Richard H
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Silverberg, Mark ...
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Satsangi, Jack
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Schreiber, Stefa ...
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Cho, Judy H
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Annese, Vito
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Hakonarson, Hako ...
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Daly, Mark J
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Parkes, Miles
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
- Articles in the publication
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Nature Genetics
- By the university
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Örebro University
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Karolinska Institutet