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- Hiensch, Anouk E, et al.
(författare)
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Design of a multinational randomized controlled trial to assess the effects of structured and individualized exercise in patients with metastatic breast cancer on fatigue and quality of life : the EFFECT study.
- 2022
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Ingår i: Trials. - : Springer Science and Business Media LLC. - 1745-6215. ; 23:1, s. 610-
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Many patients with metastatic breast cancer experience cancer- and treatment-related side effects that impair activities of daily living and negatively affect the quality of life. There is a need for interventions that improve quality of life by alleviating fatigue and other side effects during palliative cancer treatment. Beneficial effects of exercise have been observed in the curative setting, but, to date, comparable evidence in patients with metastatic breast cancer is lacking. The aim of this study is to assess the effects of a structured and individualized 9-month exercise intervention in patients with metastatic breast cancer on quality of life, fatigue, and other cancer- and treatment-related side effects.METHODS: The EFFECT study is a multinational, randomized controlled trial including 350 patients with metastatic breast cancer. Participants are randomly allocated (1:1) to an exercise or control group. The exercise group participates in a 9-month multimodal exercise program, starting with a 6-month period where participants exercise twice a week under the supervision of an exercise professional. After completing this 6-month period, one supervised session is replaced by one unsupervised session for 3 months. In addition, participants are instructed to be physically active for ≥30 min/day on all remaining days of the week, while being supported by an activity tracker and exercise app. Participants allocated to the control group receive standard medical care, general written physical activity advice, and an activity tracker, but no structured exercise program. The primary outcomes are quality of life (EORTC QLQ-C30, summary score) and fatigue (EORTC QLQ-FA12), assessed at baseline, 3, 6 (primary endpoint), and 9 months post-baseline. Secondary outcomes include physical fitness, physical performance, physical activity, anxiety, depression, pain, sleep problems, anthropometric data, body composition, and blood markers. Exploratory outcomes include quality of working life, muscle thickness, urinary incontinence, disease progression, and survival. Additionally, the cost-effectiveness of the exercise program is assessed. Adherence and safety are monitored throughout the intervention period.DISCUSSION: This large randomized controlled trial will provide evidence regarding the (cost-) effectiveness of exercise during treatment of metastatic breast cancer. If proven (cost-)effective, exercise should be offered to patients with metastatic breast cancer as part of standard care.TRIAL REGISTRATION: ClinicalTrials.gov NCT04120298 . Registered on October 9, 2019.
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| 2. |
- Kegelaers, J, et al.
(författare)
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The mental health of student-athletes : a systematic scoping review
- 2022
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Ingår i: International Review of Sport and Exercise Psychology. - Oxon : Taylor & Francis. - 1750-984X .- 1750-9858.
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Tidskriftsartikel (refereegranskat)abstract
- The purpose of this study was to provide a systematic scoping review of the research focussing on student-athletes' mental health (MH). More specifically, we aimed to describe and synthesise: (a) the study and sample characteristics of the dual career (DC) and MH research literature, (b) the types of MH outcomes examined in student-athlete populations, (c) comparisons of student-athletes' MH in relation to other populations of interest, and (d) the variables associated with student-athletes' MH. Articles were collected from four databases: SPORTDiscus, PsycInfo, Scopus, and PubMed. In total, 159 studies spanning three decades met the inclusion criteria. Most studies were conducted within the North American collegiate context. The majority (62.5%) examined mental ill-health outcomes (e.g. disordered eating, depression, anxiety), 22.6% examined positive mental health outcomes (e.g. subjective well-being, psychological well-being), and 13.8% combined both perspectives. Most studies using non-student-athlete comparison groups found that student-athletes were at a similar or decreased risk for MH problems, although notable exceptions were identified. Finally, 49 distinct variables were associated with student-athletes' MH. Most variables related to generic or sport-specific factors, with only a limited number of studies examining DC-specific factors. Findings from our scoping review are critically discussed in view of the existing literature.
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