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| 2. |
- Lipoglavsek, M, et al.
(författare)
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Breakup of the Doubly Magic 100Sn Core
- 2002
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Ingår i: Physical Review C (Nuclear Physics). - 0556-2813. ; 66:1
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Tidskriftsartikel (refereegranskat)abstract
- Level schemes of Cd-99(48)51 and In-101(49)52 nuclei have been extended to high spin. The breakup of the doubly magic Sn-100 core has been observed. Large-scale shell model calculations based on realistic nucleon-nucleon interactions are in good agreement with the experimental data. These results provide a reliable basis to predict nuclear structure properties in Sn-100 and its neighbors. For example, the size of the N=50 shell gap and the energy of the first excited state in Sn-101 have been deduced.
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| 3. |
- Lipoglavsek, M., et al.
(författare)
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First Observation of Excitation Across the 100Sn Core
- 2001
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Ingår i: Nuclear Physics, Section A. - 0375-9474. ; 682, s. 399-403
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Tidskriftsartikel (refereegranskat)abstract
- Excited states of nuclei near the doubly-magic nucleus Sn-100 were studied with the Ni-58+Cr-50 reaction. The experimental setup consisted of the GAMMASPHERE array augmented with light charged-particle and neutron detectors. Excited states were identified for the first time in the proton emitting nucleus Sb-105. Excitations across the N=Z=50 doubly closed shell were observed in Cd-99 and In-101. Some results of large-scale shell-model calculations are discussed.
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| 6. |
- Handley, Dean A., et al.
(författare)
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Biological actions of formoterol isomers
- 2002
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Ingår i: Pulmonary Pharmacology & Therapeutics. - : Elsevier BV. - 1094-5539 .- 1522-9629. ; 15:2, s. 135-145
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Tidskriftsartikel (refereegranskat)abstract
- Racemic β2 agonists, composed of equal amounts of (R)- and (S)-isomers, can display anomalous actions that compromise their effectiveness as asthma therapies. Loss of efficacy during regular use is characteristic of isoprenaline, albuterol and terbutaline and has in part been attributed to the biological effects of the (S)-isomer. This hypothesis was applied to the (R,R)- and (S,S)-isomers of formoterol. (R,R)-formoterol had 1000-times greater affinity (2.9 nm) to the human β2 adrenoceptor than (S,S)-formoterol (3100 nm), with receptor binding modulating intracellular cAMP levels. The minimum lethal intravenous (IV) dose was determined to be 100 mg/kg for (R,R)- and 50 mg/kg for (S,S)-formoterol, suggesting that the toxicity of (S,S)-formoterol may not be related to the binding of β2 adrenoceptors. In tissues pretreated with (S,S)-formoterol but not with (R,R)- or racemic formoterol contractions to high concentrations of carbachol were exaggerated. In vivo experiments with sensitized guinea pigs demonstrated that (R,R)-formoterol inhibited both histamine and antigen-induced bronchoconstriction with greater potency than (R,R/S,S)-formoterol while (S,S)-formoterol was ineffective. Metabolic radiolabeling experiments of (R,R)-, (S,S)- or (R,R/S,S)-formoterol with crude human liver phenolsulfotransferase (PST) determined the Vmax/Km values to be (0.151), (0.74) and (0.143), respectively. The reciprocal plot illustrates a 2-fold reduction in sulfation rate when (R,R)-formoterol is present as a single isomer. The data presented here suggest that (R,R)-formoterol binds to the β2 adrenoceptor and inhibits the contraction of bronchial tissues by spasmogens. However, (S,S)-formoterol exhibits properties inconsistent as an asthma therapeutic and may antagonize the actions of (R,R)-formoterol.
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| 7. |
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| 8. |
- Lipoglavsek, M, et al.
(författare)
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100Sn Core Excitations in 102In
- 2002
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Ingår i: Physical Review C (Nuclear Physics). - 0556-2813. ; 65:2
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Tidskriftsartikel (refereegranskat)abstract
- Nuclei in the vicinity of the doubly-magic Sn-100 nucleus have been studied, and an extended level scheme for In-102 has been established. The level structure comprises both the negative parity states involving the nuh(11/2) orbital, and levels due to the breakup of the doubly-magic Sn-100 core. Results of a large-scale shell model calculation, using realistic and empirical effective interactions with Sr-88 as a core, are in very good agreement with the experimental data.
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| 9. |
- Lipoglavsek, M, et al.
(författare)
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Excited States of the Proton Emitter 105Sb
- 2002
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Ingår i: Physical Review C (Nuclear Physics). - 0556-2813. ; 65:5
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Tidskriftsartikel (refereegranskat)abstract
- Excited states in the proton emitter Sb-105 have been investigated for the first time. The nucleus was populated in the reaction Cr-50(Ni-58,1p2n). The GAMMASPHERE Ge-detector array was used together with Microball and the Neutron Shell for selection of the reaction channel. The experimental level scheme agrees well with results of a shell model calculation that uses realistic effective interactions derived from the CD-Bonn nucleon-nucleon interaction and Sn-100 as a closed-shell core.
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| 10. |
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