Search: (WFRF:(Demissie Serkalem)) pers:(Bis Joshua C.)
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Association of low-...
Association of low-frequency and rare coding-sequence variants with blood lipids and coronary heart disease in 56,000 whites and blacks.
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Peloso, Gina M (author)
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Auer, Paul L (author)
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Bis, Joshua C (author)
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show more...
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Voorman, Arend (author)
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Morrison, Alanna C (author)
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Stitziel, Nathan O (author)
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Brody, Jennifer A (author)
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Khetarpal, Sumeet A (author)
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Crosby, Jacy R (author)
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Fornage, Myriam (author)
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Isaacs, Aaron (author)
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Jakobsdottir, Johanna (author)
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Feitosa, Mary F (author)
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Davies, Gail (author)
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Huffman, Jennifer E (author)
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Manichaikul, Ani (author)
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Davis, Brian (author)
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Lohman, Kurt (author)
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Joon, Aron Y (author)
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Smith, Albert V (author)
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Grove, Megan L (author)
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Zanoni, Paolo (author)
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Redon, Valeska (author)
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Demissie, Serkalem (author)
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Lawson, Kim (author)
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Peters, Ulrike (author)
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Carlson, Christopher (author)
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Jackson, Rebecca D (author)
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Ryckman, Kelli K (author)
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Mackey, Rachel H (author)
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Robinson, Jennifer G (author)
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Siscovick, David S (author)
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Schreiner, Pamela J (author)
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Mychaleckyj, Josyf C (author)
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Pankow, James S (author)
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Hofman, Albert (author)
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Uitterlinden, Andre G (author)
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Harris, Tamara B (author)
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Taylor, Kent D (author)
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Stafford, Jeanette M (author)
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Reynolds, Lindsay M (author)
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Marioni, Riccardo E (author)
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Dehghan, Abbas (author)
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Franco, Oscar H (author)
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Patel, Aniruddh P (author)
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Lu, Yingchang (author)
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- Hindy, George (author)
- Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups
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Gottesman, Omri (author)
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Bottinger, Erwin P (author)
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- Melander, Olle (author)
- Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups
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- Orho-Melander, Marju (author)
- Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups
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Loos, Ruth J F (author)
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Duga, Stefano (author)
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Merlini, Piera Angelica (author)
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Farrall, Martin (author)
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Goel, Anuj (author)
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Asselta, Rosanna (author)
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Girelli, Domenico (author)
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Martinelli, Nicola (author)
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Shah, Svati H (author)
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Kraus, William E (author)
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Li, Mingyao (author)
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Rader, Daniel J (author)
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Reilly, Muredach P (author)
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McPherson, Ruth (author)
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Watkins, Hugh (author)
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Ardissino, Diego (author)
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Zhang, Qunyuan (author)
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Wang, Judy (author)
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Tsai, Michael Y (author)
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Taylor, Herman A (author)
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Correa, Adolfo (author)
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Griswold, Michael E (author)
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Lange, Leslie A (author)
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Starr, John M (author)
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Rudan, Igor (author)
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Eiriksdottir, Gudny (author)
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Launer, Lenore J (author)
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Ordovas, Jose M (author)
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Levy, Daniel (author)
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Chen, Y-D Ida (author)
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Reiner, Alexander P (author)
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Hayward, Caroline (author)
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Polasek, Ozren (author)
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Deary, Ian J (author)
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Borecki, Ingrid B (author)
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Liu, Yongmei (author)
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Gudnason, Vilmundur (author)
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Wilson, James G (author)
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van Duijn, Cornelia M (author)
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Kooperberg, Charles (author)
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Rich, Stephen S (author)
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Psaty, Bruce M (author)
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Rotter, Jerome I (author)
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O'Donnell, Christopher J (author)
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Rice, Kenneth (author)
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Boerwinkle, Eric (author)
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Kathiresan, Sekar (author)
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Cupples, L Adrienne (author)
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(creator_code:org_t)
- Elsevier BV, 2014
- 2014
- English.
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In: American Journal of Human Genetics. - : Elsevier BV. - 0002-9297. ; 94:2, s. 223-232
- Related links:
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http://www.ncbi.nlm....
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http://dx.doi.org/10...
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http://www.cell.com/...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Subject headings
Close
- Low-frequency coding DNA sequence variants in the proprotein convertase subtilisin/kexin type 9 gene (PCSK9) lower plasma low-density lipoprotein cholesterol (LDL-C), protect against risk of coronary heart disease (CHD), and have prompted the development of a new class of therapeutics. It is uncertain whether the PCSK9 example represents a paradigm or an isolated exception. We used the "Exome Array" to genotype >200,000 low-frequency and rare coding sequence variants across the genome in 56,538 individuals (42,208 European ancestry [EA] and 14,330 African ancestry [AA]) and tested these variants for association with LDL-C, high-density lipoprotein cholesterol (HDL-C), and triglycerides. Although we did not identify new genes associated with LDL-C, we did identify four low-frequency (frequencies between 0.1% and 2%) variants (ANGPTL8 rs145464906 [c.361C>T; p.Gln121(∗)], PAFAH1B2 rs186808413 [c.482C>T; p.Ser161Leu], COL18A1 rs114139997 [c.331G>A; p.Gly111Arg], and PCSK7 rs142953140 [c.1511G>A; p.Arg504His]) with large effects on HDL-C and/or triglycerides. None of these four variants was associated with risk for CHD, suggesting that examples of low-frequency coding variants with robust effects on both lipids and CHD will be limited.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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To the university's database
- By the author/editor
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Peloso, Gina M
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Auer, Paul L
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Bis, Joshua C
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Voorman, Arend
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Morrison, Alanna ...
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Stitziel, Nathan ...
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show more...
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Brody, Jennifer ...
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Khetarpal, Sumee ...
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Crosby, Jacy R
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Fornage, Myriam
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Isaacs, Aaron
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Jakobsdottir, Jo ...
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Feitosa, Mary F
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Davies, Gail
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Huffman, Jennife ...
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Manichaikul, Ani
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Davis, Brian
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Lohman, Kurt
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Joon, Aron Y
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Smith, Albert V
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Grove, Megan L
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Zanoni, Paolo
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Redon, Valeska
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Demissie, Serkal ...
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Lawson, Kim
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Peters, Ulrike
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Carlson, Christo ...
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Jackson, Rebecca ...
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Ryckman, Kelli K
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Mackey, Rachel H
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Robinson, Jennif ...
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Siscovick, David ...
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Schreiner, Pamel ...
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Mychaleckyj, Jos ...
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Pankow, James S
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Hofman, Albert
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Uitterlinden, An ...
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Harris, Tamara B
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Taylor, Kent D
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Stafford, Jeanet ...
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Reynolds, Lindsa ...
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Marioni, Riccard ...
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Dehghan, Abbas
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Franco, Oscar H
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Patel, Aniruddh ...
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Lu, Yingchang
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Hindy, George
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Gottesman, Omri
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Bottinger, Erwin ...
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Melander, Olle
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Orho-Melander, M ...
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Loos, Ruth J F
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Duga, Stefano
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Merlini, Piera A ...
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Farrall, Martin
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Goel, Anuj
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Asselta, Rosanna
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Girelli, Domenic ...
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Martinelli, Nico ...
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Shah, Svati H
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Kraus, William E
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Li, Mingyao
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Rader, Daniel J
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Reilly, Muredach ...
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McPherson, Ruth
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Watkins, Hugh
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Ardissino, Diego
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Zhang, Qunyuan
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Wang, Judy
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Tsai, Michael Y
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Taylor, Herman A
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Correa, Adolfo
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Griswold, Michae ...
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Lange, Leslie A
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Starr, John M
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Rudan, Igor
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Eiriksdottir, Gu ...
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Launer, Lenore J
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Ordovas, Jose M
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Levy, Daniel
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Chen, Y-D Ida
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Reiner, Alexande ...
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Hayward, Carolin ...
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Polasek, Ozren
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Deary, Ian J
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Borecki, Ingrid ...
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Liu, Yongmei
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Gudnason, Vilmun ...
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Wilson, James G
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van Duijn, Corne ...
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Kooperberg, Char ...
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Rich, Stephen S
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Psaty, Bruce M
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Rotter, Jerome I
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O'Donnell, Chris ...
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Rice, Kenneth
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Boerwinkle, Eric
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Kathiresan, Seka ...
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Cupples, L Adrie ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
- Articles in the publication
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American Journal ...
- By the university
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Lund University