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(WFRF:(Drevon Christian A)) pers:(Roche Helen M.)
 

Sökning: (WFRF:(Drevon Christian A)) pers:(Roche Helen M.) > (2019) > Effects of dietary ...

Effects of dietary fat on insulin secretion in subjects with the metabolic syndrome

Gulseth, Hanne L. (författare)
Univ Oslo, Oslo Univ Hosp, Dept Endocrinol Morbid Obes & Prevent Med, Oslo, Norway;Univ Oslo, Fac Med, Oslo, Norway;Univ Oslo, Fac Med, Inst Basic Med Sci, Dept Nutr, Oslo, Norway;Norwegian Inst Publ Hlth, Dept Chron Dis & Ageing, Oslo, Norway
Gjelstad, Ingrid M. F. (författare)
Univ Oslo, Oslo Univ Hosp, Dept Endocrinol Morbid Obes & Prevent Med, Oslo, Norway;Univ Oslo, Fac Med, Oslo, Norway;Univ Oslo, Fac Med, Inst Basic Med Sci, Dept Nutr, Oslo, Norway
Tiereny, Audrey C. (författare)
Univ Coll Dublin, UCD Conway Inst, Nutrigen Res Grp, Dublin, Ireland;Univ Coll Dublin, UCD Inst Food & Hlth, Sch Publ Hlth Physiotherapy & Sports Sci, Dublin, Ireland;Univ Limerick, Sch Allied Hlth, Limerick, Ireland;La Trobe Univ, Sch Allied Hlth, Melbourne, Vic, Australia
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McCarthy, Danielle (författare)
Univ Reading, Dept Food Biosci, Hugh Sinclair Unit Human Nutr, Reading, Berks, England;Queens Univ Belfast, Northern Ireland Technol Ctr, Inst Global Food Secur, Belfast, Antrim, North Ireland
Lovegrove, Julie A. (författare)
Univ Reading, Dept Food Biosci, Hugh Sinclair Unit Human Nutr, Reading, Berks, England;Univ Reading, Inst Cardiovasc & Metab Res, Reading, Berks, England
Defoort, Catherine (författare)
Aix Marseille Univ, INSERM, INRA, C2VN, Marseille, France
Blaak, Ellen E. (författare)
Maastricht Univ, Med Ctr, Sch Nutr Toxicol & Metab, NUTRIM, Maastricht, Netherlands
Lopez-Miranda, Jose (författare)
Univ Cordoba, Hosp Univ Reina Sofia, Inst Maimonides Invest Biomed Cordoba IMIBIC, Lipids & Atherosclerosis Res Unit, Madrid, Spain;Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr CIBEROBN, Madrid, Spain
Dembinska-Kiec, Aldona (författare)
Jagiellonian Univ, Dept Clin Biochem, Med Coll, Krakow, Poland
Risérus, Ulf, 1967- (författare)
Uppsala universitet,Klinisk nutrition och metabolism
Roche, Helen M. (författare)
Univ Coll Dublin, UCD Conway Inst, Nutrigen Res Grp, Dublin, Ireland;Univ Coll Dublin, UCD Inst Food & Hlth, Sch Publ Hlth Physiotherapy & Sports Sci, Dublin, Ireland
Drevon, Christian A. (författare)
Univ Oslo, Fac Med, Inst Basic Med Sci, Dept Nutr, Oslo, Norway
Birkeland, Kare, I (författare)
Univ Oslo, Oslo Univ Hosp, Dept Endocrinol Morbid Obes & Prevent Med, Oslo, Norway;Univ Oslo, Fac Med, Oslo, Norway;Univ Oslo, Fac Med, Inst Clin Med, Oslo, Norway
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 (creator_code:org_t)
BIOSCIENTIFICA LTD, 2019
2019
Engelska.
Ingår i: European Journal of Endocrinology. - : BIOSCIENTIFICA LTD. - 0804-4643 .- 1479-683X. ; 180:5, s. 321-328
Relaterad länk:
https://urn.kb.se/re...
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https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Objective: Impaired insulin secretion and action contribute to the development of type 2 diabetes. Dietary fat modification may improve insulin sensitivity, whereas the effect on insulin secretion is unclear. We investigated the effect of dietary fat modification on insulin secretion in subjects with the metabolic syndrome.Design: In a 12-week pan-European parallel, randomized controlled dietary intervention trial (LIPGENE), 486 subjects were assigned to four isoenergetic diets: high-fat diets rich in saturated fat (HSFA) or monounsaturated fat (HMUFA) or low-fat, high-complex carbohydrate diets with (LFHCC n-3) or without (LFHCC control) 1.2 g/day of n-3 PUFA supplementation. Insulin secretion was estimated as acute insulin response to glucose (AIRg) and disposition index (DI), modeled from an intravenous glucose tolerance test.Results: There were no overall effect of the dietary intervention on AIRg and DI in the total cohort, in neither the highfat nor LFHCC groups. We observed significant diet*fasting glucose category interactions for AIRg (P = 0.021) and DI (P = 0.001) in the high-fat groups. In subjects with normal fasting glucose and preserved first phase insulin secretion, the HMUFA diet increased, whereas the HSFA diet reduced AIRg (P = 0.015) and DI (P = 0.010).Conclusions: The effects of dietary fat modification on insulin secretion were minor, and only evident in normoglycemic subjects. In this case, the HMUFA diet improved AIRg and DI, as compared to the HSFA diet.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskap -- Näringslära (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)

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