1. |
|
|
2. |
|
|
3. |
- Edlund, C, et al.
(författare)
-
Effect of quinolones on intestinal ecology
- 1999
-
Ingår i: Drugs. - : Springer Science and Business Media LLC. - 0012-6667. ; 5858 Suppl 2, s. 65-70
-
Tidskriftsartikel (refereegranskat)
|
|
4. |
- Fang, Hong, et al.
(författare)
-
Identification of the metallo-beta-lactamase gene from clinical isolates of Bacteroides fragilis
- 1999
-
Ingår i: Anaerobe. - : Elsevier BV. - 1075-9964 .- 1095-8274. ; 5:3-4, s. 431-434
-
Tidskriftsartikel (refereegranskat)abstract
- Bacteroides fragilis is one of the organisms known to produce carbapenem-hydrolysing metallo-beta-lactamase, which can confer resistance to a wide variety of beta-lactams. The purpose of this study was to identify carbapenem-hydrolysing metallo-beta-lactamase-producing B. fragilis strains by means of PCR assay, nucleotide sequencing and enzyme inhibition studies. Ten beta-lactam-resistant B. fragilis isolates were investigated. Four imipenem-resistant strains among the 10 isolates gave positive reactions in the PCR assay. The nucleotide sequences of the PCR products from two imipenem-resistant strains shared >98% similarity with the metallo-beta-lactamase gene from B. fragilis TAL 3636, which was used as a control. The amino acid sequence homology between the two imipenem-resistant strains and B. fragilis TAL 3636 was 99.2%. These strains produced high amounts of Zn2+-dependent beta-lactamases which were inactivated by EDTA.
|
|
5. |
|
|