| 1. |
- Conti, David, V, et al.
(författare)
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Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction
- 2021
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Ingår i: Nature Genetics. - : Springer Nature. - 1061-4036 .- 1546-1718. ; 53:1, s. 65-75
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Tidskriftsartikel (refereegranskat)abstract
- Prostate cancer is a highly heritable disease with large disparities in incidence rates across ancestry populations. We conducted a multiancestry meta-analysis of prostate cancer genome-wide association studies (107,247 cases and 127,006 controls) and identified 86 new genetic risk variants independently associated with prostate cancer risk, bringing the total to 269 known risk variants. The top genetic risk score (GRS) decile was associated with odds ratios that ranged from 5.06 (95% confidence interval (CI), 4.84-5.29) for men of European ancestry to 3.74 (95% CI, 3.36-4.17) for men of African ancestry. Men of African ancestry were estimated to have a mean GRS that was 2.18-times higher (95% CI, 2.14-2.22), and men of East Asian ancestry 0.73-times lower (95% CI, 0.71-0.76), than men of European ancestry. These findings support the role of germline variation contributing to population differences in prostate cancer risk, with the GRS offering an approach for personalized risk prediction. A meta-analysis of genome-wide association studies across different populations highlights new risk loci and provides a genetic risk score that can stratify prostate cancer risk across ancestries.
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| 2. |
- Barreflod, Olle, et al.
(författare)
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Studying the ability to use sport watches when running - insights from a small pilot study
- 2022
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Ingår i: ECIS 2022 Research-in-Progress Papers.
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Konferensbidrag (refereegranskat)abstract
- Digitalization is a phenomenon that seems to affect all aspects of contemporary society. The sports domain is by no means excluded from this development. In sports, the sport watch might be one of the most iconic symbols in how digitalization has enhanced, changed and developed how physical activities are experienced and measured. Despite the massive adoption of sport watches among runners and other athletes, few studies have explored how sports watches are used in the specific activity they are designed for. The study presented in this research in progress paper is small and should be viewed as a small attempt to outline an approach to study digital technology use in sports activities.
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| 3. |
- Christensen, Martin, 1982-, et al.
(författare)
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Sculpting with SARA (Spatial Augmented Reality Assistance)
- 2023
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- We explored how spatial augmented reality can assist sculpting in the physicalspace based on a digital 3D-model. As a result of our findings we propose asetup of software and hardware as well as methods to use these (SARA), thatcan visually guide an artist in the work of manual transfer of digital to physicalthree-dimensional form. As a tool SARA could be used much more loosely; therelationship between a digital 3D sketch and a finished sculpture canconceptually be thought of as similar to a rough underdrawing and a finished oilpainting. In this case, the 3d sketch is there as an initial idea and a guide, but notas a ground truth. Beyond the scope of this project, SARA could be furtherexplored in relation to artistic questions. In practical terms, SARA works in thefollowing way: The colors projected during sculpting indicate how much thedistance deviates from the digital sketch in relation to the projector. The colorsare updated in real-time, as a 3D depth camera is continuously scanning theworking space.
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| 4. |
- Wang, Anqi, et al.
(författare)
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Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants
- 2023
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Ingår i: Nature Genetics. - : Springer Nature. - 1061-4036 .- 1546-1718. ; 55:12, s. 2065-2074
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Tidskriftsartikel (refereegranskat)abstract
- The transferability and clinical value of genetic risk scores (GRSs) across populations remain limited due to an imbalance in genetic studies across ancestrally diverse populations. Here we conducted a multi-ancestry genome-wide association study of 156,319 prostate cancer cases and 788,443 controls of European, African, Asian and Hispanic men, reflecting a 57% increase in the number of non-European cases over previous prostate cancer genome-wide association studies. We identified 187 novel risk variants for prostate cancer, increasing the total number of risk variants to 451. An externally replicated multi-ancestry GRS was associated with risk that ranged from 1.8 (per standard deviation) in African ancestry men to 2.2 in European ancestry men. The GRS was associated with a greater risk of aggressive versus non-aggressive disease in men of African ancestry (P = 0.03). Our study presents novel prostate cancer susceptibility loci and a GRS with effective risk stratification across ancestry groups.
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| 5. |
- Abramian, David, 1992-, et al.
(författare)
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Diffusion-Informed Spatial Smoothing of fMRI Data in White Matter Using Spectral Graph Filters
- 2021
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Ingår i: NeuroImage. - : Elsevier. - 1053-8119 .- 1095-9572. ; 237
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Tidskriftsartikel (refereegranskat)abstract
- Brain activation mapping using functional magnetic resonance imaging (fMRI) has been extensively studied in brain gray matter (GM), whereas in large disregarded for probing white matter (WM). This unbalanced treatment has been in part due to controversies in relation to the nature of the blood oxygenation level-dependent (BOLD) contrast in WM and its detachability. However, an accumulating body of studies has provided solid evidence of the functional significance of the BOLD signal in WM and has revealed that it exhibits anisotropic spatio-temporal correlations and structure-specific fluctuations concomitant with those of the cortical BOLD signal. In this work, we present an anisotropic spatial filtering scheme for smoothing fMRI data in WM that accounts for known spatial constraints on the BOLD signal in WM. In particular, the spatial correlation structure of the BOLD signal in WM is highly anisotropic and closely linked to local axonal structure in terms of shape and orientation, suggesting that isotropic Gaussian filters conventionally used for smoothing fMRI data are inadequate for denoising the BOLD signal in WM. The fundamental element in the proposed method is a graph-based description of WM that encodes the underlying anisotropy observed across WM, derived from diffusion-weighted MRI data. Based on this representation, and leveraging graph signal processing principles, we design subject-specific spatial filters that adapt to a subject’s unique WM structure at each position in the WM that they are applied at. We use the proposed filters to spatially smooth fMRI data in WM, as an alternative to the conventional practice of using isotropic Gaussian filters. We test the proposed filtering approach on two sets of simulated phantoms, showcasing its greater sensitivity and specificity for the detection of slender anisotropic activations, compared to that achieved with isotropic Gaussian filters. We also present WM activation mapping results on the Human Connectome Project’s 100-unrelated subject dataset, across seven functional tasks, showing that the proposed method enables the detection of streamline-like activations within axonal bundles.
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| 6. |
- Abramian, David, 1992-, et al.
(författare)
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Improved Functional MRI Activation Mapping in White Matter Through Diffusion-Adapted Spatial Filtering
- 2020
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Ingår i: ISBI 2020. - : IEEE. - 1945-8452 .- 1945-7928. - 9781538693308
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Konferensbidrag (refereegranskat)abstract
- Brain activation mapping using functional MRI (fMRI) based on blood oxygenation level-dependent (BOLD) contrast has been conventionally focused on probing gray matter, the BOLD contrast in white matter having been generally disregarded. Recent results have provided evidence of the functional significance of the white matter BOLD signal, showing at the same time that its correlation structure is highly anisotropic, and related to the diffusion tensor in shape and orientation. This evidence suggests that conventional isotropic Gaussian filters are inadequate for denoising white matter fMRI data, since they are incapable of adapting to the complex anisotropic domain of white matter axonal connections. In this paper we explore a graph-based description of the white matter developed from diffusion MRI data, which is capable of encoding the anisotropy of the domain. Based on this representation we design localized spatial filters that adapt to white matter structure by leveraging graph signal processing principles. The performance of the proposed filtering technique is evaluated on semi-synthetic data, where it shows potential for greater sensitivity and specificity in white matter activation mapping, compared to isotropic filtering.
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| 7. |
- Amano, Tatsuya, et al.
(författare)
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Transforming Practice : Checklists for Delivering Change
- 2022
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Ingår i: Transforming Conservation : A Practical Guide to Evidence and Decision Making - A Practical Guide to Evidence and Decision Making. - 9781800648586 - 9781800648562 ; , s. 367-386
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Bokkapitel (refereegranskat)abstract
- Delivering a revolution in evidence use requires a cultural change across society. For a wide range of groups (practitioners, knowledge brokers, organisations, organisational leaders, policy makers, funders, researchers, journal publishers, the wider conservation community, educators, writers, and journalists), options are described to facilitate a change in practice, and a series of downloadable checklists is provided.
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| 8. |
- Andersson, Martin, 1977-, et al.
(författare)
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Regeringens krispaket löser inte småföretagens problem
- 2020
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Ingår i: Dagens Nyheter. ; 22 mars
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Tidskriftsartikel (populärvet., debatt m.m.)abstract
- Ingress: Åtgärderna för att hålla uppe efterfrågan med sänkta räntor och beredskapen att vidta finanspolitiska åtgärder är föredömliga. Men de aviserade krispaketen löser inte det som kan beskrivas som en efterfrågekollaps, skriver tre nationalekonomer och föreslår kort- och långsiktiga lösningar samt en reformkommission.
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| 9. |
- Andersson, Martin, et al.
(författare)
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Spatial variations in financial constraints of SMEs-evidence from firm-level estimates of investment-cash flow sensitivities in Sweden
- 2023
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Ingår i: Small Business Economics. - : Springer. - 0921-898X .- 1573-0913. ; 60:4, s. 1683-1698
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Tidskriftsartikel (refereegranskat)abstract
- Plain English Summary We show that small- and medium-sized enterprises (SMEs) located outside the main city regions are more dependent on internal cash flow in their investments compared to SME urban city regions. Our findings clearly show that, as access to agglomerated economies decreases, financial constraints faced by the SMEs increase. The investment ability of SMEs in rural regions depends on own cash flow more but revenues in smaller regions tend to be smaller too-implying that the cash flow is likely to be lower. As a result, SMEs in smaller and more remote places would find it harder to invest and, therefore, to grow or increase productivity. The fact that such a consistent pattern of increasing investment-cash flow sensitivity is clearly observable in Sweden, one of the least regionally unequal countries, only reinforces the importance of considering the spatial dimension in policies targeted at closing SME financing gap. It is well established that there is uneven availability of credit across space, in particular for SMEs. The evidence on whether this translates into differences in actual business investments remains scarce. We assess this question by using firm-level data for Swedish firms and estimate the extent to which the average investment-cash flow sensitivities of firms vary across the urban-rural hierarchy. We find that the world of financing is not yet flat for the majority of Swedish SMEs. Companies located in non-metro regions are most dependent on own cash flow in their investments. The results hold for all firms, firms of different sizes, firms operating in low-end services, unaffiliated firms and those belonging to domestic corporations. In contrast, investment-cash flow sensitivity of firms operating in high-tech services and those belonging to a multinational enterprise does not differ geographically. On average, regional investment-cash flow sensitivity is lower in bigger, denser and more educated local labour market regions; it is higher in regions with greater concentration of SMEs.
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| 10. |
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