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Träfflista för sökning "(WFRF:(Elovaara I)) srt2:(1995-1999) srt2:(1997)"

Sökning: (WFRF:(Elovaara I)) srt2:(1995-1999) > (1997)

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  • Raininko, Raili, et al. (författare)
  • A prospective radiologic and neurologic follow-up study of 61 HIV-infected subjects : Early beginning and slow progression of brain atrophy
  • 1997
  • Ingår i: European Journal of Neurology. - 1351-5101 .- 1468-1331. ; 4:2, s. 143-151
  • Tidskriftsartikel (refereegranskat)abstract
    • Abstract: The course of the organic brain disease caused by human immunodeficiency virus (HIV-1) was evaluated in a follow-up study. The primary material included 200 consecutive HIV-1 infected persons. Sixty-one subjects, in whom other brain-affecting factors were excluded, consented to the follow-up. They underwent 278 radiologic examinations: computed tomography, magnetic resonance imaging, or a combination of both (mean 4.6 examinations/subject). Clinical neurologic status and, in 40 subjects, cognitive performance were repeatedly evaluated. Sixteen subjects were followed up until death and 11 of them were autopsied. Median follow-up time was 27 mo (range 2.5-66 mo). The most common radiologic finding was atrophy, found in 19 subjects at study entry and developing in 10 subjects during the study. Twenty-four subjects (39%) showed the development and/or progression of atrophy. Atrophic changes progressed most rapidly in acquired immunodeficiency syndrome (AIDS), but mild developing/progressive atrophy was found even in 33% of asymptomatic or neurologically intact subjects. Cognitive and radiologic worsening were simultaneous in 6/7 subjects with declining neuropsychologic test performance. Signal intensity changes including HIV-1 leukoencephalopathy appeared in AIDS patients with clear cognitive decline.
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