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Developmental vitam...
Developmental vitamin D and autism spectrum disorders: findings from the Stockholm Youth Cohort
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- Lee, BK (författare)
- Karolinska Institutet
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Eyles, DW (författare)
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- Magnusson, C (författare)
- Karolinska Institutet
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Newschaffer, CJ (författare)
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McGrath, JJ (författare)
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Kvaskoff, D (författare)
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Ko, P (författare)
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- Dalman, C (författare)
- Karolinska Institutet
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- Karlsson, H (författare)
- Karolinska Institutet
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- Gardner, RM (författare)
- Karolinska Institutet
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(creator_code:org_t)
- 2019-11-06
- 2021
- Engelska.
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Ingår i: Molecular psychiatry. - : Springer Science and Business Media LLC. - 1476-5578 .- 1359-4184. ; 26:5, s. 1578-1588
- Relaterad länk:
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https://www.nature.c...
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http://kipublication...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- Animal studies indicate that early life vitamin D is crucial for proper neurodevelopment. Few studies have examined whether maternal and neonatal vitamin D concentrations influence risk of autism spectrum disorders (ASD). Participants were sampled from the Stockholm Youth Cohort, a register-based cohort in Sweden. Concentrations of total 25-hydroxyvitamin D (25OHD) were assessed from maternal and neonatal biosamples using a highly sensitive liquid chromatography tandem mass spectrometry method. The maternal sample consisted of 449 ASD cases and 574 controls, the neonatal sample: 1399 ASD cases and 1607 controls; and the paired maternal-neonatal sample: 340 ASD cases and 426 controls. Maternal 25OHD was not associated with child ASD in the overall sample. However, in Nordic-born mothers, maternal 25OHD insufficiency (25 − <50 nmol/L) at ~11 weeks gestation was associated with 1.58 times higher odds of ASD (95% CI: 1.00, 2.49) as compared with 25OHD sufficiency (≥50 nmol/L). Neonatal 25OHD < 25 nmol/L was associated with 1.33 times higher odds of ASD (95% CI: 1.02, 1.75) as compared with 25OHD ≥ 50 nmol/L. Sibling-matched control analyses indicated these associations were not likely due to familial confounding. Children with both maternal 25OHD and neonatal 25OHD below the median had 1.75 (95% CI: 1.08, 2.86) times the odds of ASD compared with children with maternal and neonatal 25OHD both below the median. Our results are consistent with an increasing body of evidence suggesting that vitamin D concentrations in early life may be associated with increased risk of neurodevelopmental disorders including ASD.
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- Av författaren/redakt...
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Lee, BK
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Eyles, DW
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Magnusson, C
-
Newschaffer, CJ
-
McGrath, JJ
-
Kvaskoff, D
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visa fler...
-
Ko, P
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Dalman, C
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Karlsson, H
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Gardner, RM
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visa färre...
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Molecular psychi ...
- Av lärosätet
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Karolinska Institutet