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1.
  • Ronkainen, Justiina, et al. (författare)
  • LongITools: Dynamic longitudinal exposome trajectories in cardiovascular and metabolic noncommunicable diseases
  • 2022
  • Ingår i: Environmental Epidemiology. - 2474-7882. ; 6:1
  • Tidskriftsartikel (refereegranskat)abstract
    • The current epidemics of cardiovascular and metabolic noncommunicable diseases have emerged alongside dramatic modifications in lifestyle and living environments. These correspond to changes in our "modern" postwar societies globally characterized by rural-to-urban migration, modernization of agricultural practices, and transportation, climate change, and aging. Evidence suggests that these changes are related to each other, although the social and biological mechanisms as well as their interactions have yet to be uncovered. LongITools, as one of the 9 projects included in the European Human Exposome Network, will tackle this environmental health equation linking multidimensional environmental exposures to the occurrence of cardiovascular and metabolic noncommunicable diseases.
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2.
  • Vogelezang, Suzanne, et al. (författare)
  • Genetics of early-life head circumference and genetic correlations with neurological, psychiatric and cognitive outcomes.
  • 2022
  • Ingår i: BMC medical genomics. - : Springer Science and Business Media LLC. - 1755-8794. ; 15:1
  • Tidskriftsartikel (refereegranskat)abstract
    • Head circumference is associated with intelligence and tracks from childhood into adulthood.We performed a genome-wide association study meta-analysis and follow-up of head circumference in a total of 29,192 participants between 6 and 30months of age.Seven loci reached genome-wide significance in the combined discovery and replication analysis of which three loci near ARFGEF2, MYCL1, and TOP1, were novel. We observed positive genetic correlations for early-life head circumference with adult intracranial volume, years of schooling, childhood and adult intelligence, but not with adult psychiatric, neurological, or personality-related phenotypes.The results of this study indicate that the biological processes underlying early-life head circumference overlap largely with those of adult head circumference. The associations of early-life head circumference with cognitive outcomes across the life course are partly explained by genetics.
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