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Maternal age is rel...
Maternal age is related to offspring DNA methylation : a meta-analysis of results from the pace consortium
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- Yeung, Edwina (författare)
- Epidemiology Branch, Division of Population Health Research, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, MD, Bethesda, United States
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- Biedrzycki, Richard J. (författare)
- Division of Intramural Research, Glotech Inc., Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, MD, Bethesda, United States
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- Gómez Herrera, Laura C. (författare)
- ISGlobal, Institute for Global Health, Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain
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- Issarapu, Prachand (författare)
- MRC Unit the Gambia at the London School of Hygiene and Tropical Medicine (LSHTM), Banjul, Gambia
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- Dou, John (författare)
- Department of Epidemiology, School of Public Health, University of Michigan, MI, Ann Arbor, United States
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- Marques, Irene Fontes (författare)
- Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands; Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands
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- Mansuri, Sohail Rafik (författare)
- Genomic Research on Complex Diseases (GRC-Group), CSIR-Centre for Cellular and Molecular Biology, Telangana, Hyderabad, India
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- Page, Christian Magnus (författare)
- Oslo Centre for Biostatistics and Epidemiology, Oslo University Hospital, Oslo, Norway
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- Harbs, Justin (författare)
- Umeå universitet,Institutionen för diagnostik och intervention,Onkologi
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- Khodasevich, Dennis (författare)
- Environmental Health Sciences, Berkeley Public Health, CERCH, University of California, CA, Berkeley, United States
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- Poisel, Eric (författare)
- Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany
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- Niu, Zhongzheng (författare)
- Department of Population and Public Health Science, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
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- Allard, Catherine (författare)
- Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke (CHUS), QC, Sherbrooke, Canada
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- Casey, Emma (författare)
- Department of Epidemiology, Rollins School of Public Health, Emory University, GA, Atlanta, United States
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- Berstein, Fernanda Morales (författare)
- Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom; Bristol Medical School Population Health Sciences, University of Bristol, Bristol, United Kingdom
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- Mancano, Giulia (författare)
- Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom; Bristol Medical School Population Health Sciences, University of Bristol, Bristol, United Kingdom
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- Elliott, Hannah R. (författare)
- Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom; Bristol Medical School Population Health Sciences, University of Bristol, Bristol, United Kingdom
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- Richmond, Rebecca (författare)
- Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom; Bristol Medical School Population Health Sciences, University of Bristol, Bristol, United Kingdom
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- He, Yiyan (författare)
- Research Unit of Population Health, University of Oulu, Oulu, Finland
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- Ronkainen, Justiina (författare)
- Research Unit of Population Health, University of Oulu, Oulu, Finland
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- Sebert, Sylvain (författare)
- Research Unit of Population Health, University of Oulu, Oulu, Finland
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- Bell, Erin M. (författare)
- Department of Environmental Health Sciences and Epidemiology and Biostatistics, University at Albany School of Public Health, NY, Albany, United States
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- Sharp, Gemma (författare)
- Department of Psychology, University of Exeter, Exeter, United Kingdom
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- Mumford, Sunni L. (författare)
- Department of Biostatistics, Epidemiology and Informatics and Department of Obstetrics and Gynecology, Perelman School of Medicine, University of Pennsylvania, PA, Philadelphia, United States
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- Schisterman, Enrique F. (författare)
- Department of Biostatistics, Epidemiology and Informatics and Department of Obstetrics and Gynecology, Perelman School of Medicine, University of Pennsylvania, PA, Philadelphia, United States
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- Chandak, Giriraj R. (författare)
- Genomic Research on Complex Diseases (GRC-Group), CSIR-Centre for Cellular and Molecular Biology, Telangana, Hyderabad, India
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- Fall, Caroline H. D. (författare)
- MRC Lifecourse Epidemiology Centre, University of Southampton, UK, Southampton, United Kingdom
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- Sahariah, Sirazul A. (författare)
- Centre for the Study of Social Change, Mumbai, India
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- Silver, Matt J. (författare)
- MRC Unit the Gambia at the London School of Hygiene and Tropical Medicine (LSHTM), Banjul, Gambia
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- Prentice, Andrew M. (författare)
- MRC Unit the Gambia at the London School of Hygiene and Tropical Medicine (LSHTM), Banjul, Gambia
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- Bouchard, Luigi (författare)
- Department of Biochemistry and Functional Genomics, Centre intégré Universitaire de santé et de Services Sociaux (CIUSSS) du Saguenay-Lac-St-Jean, Université de Sherbrooke, QC, Sherbrooke, Canada; Department of Laboratory Medicine, CIUSSS du Saguenay-Lac-Saint-Jean – Hôpital de Chicoutimi, QC, Chicoutimi, Canada
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- Domellöf, Magnus, 1963- (författare)
- Umeå universitet,Pediatrik
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- West, Christina E. (författare)
- Umeå universitet,Pediatrik
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- Holland, Nina (författare)
- Environmental Health Sciences, Berkeley Public Health, CERCH, University of California, CA, Berkeley, United States
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- Cardenas, Andres (författare)
- Department of Epidemiology and Population Health, Stanford University, CA, Stanford, United States
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- Eskenazi, Brenda (författare)
- Environmental Health Sciences, Berkeley Public Health, CERCH, University of California, CA, Berkeley, United States
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- Zillich, Lea (författare)
- Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany
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- Witt, Stephanie H. (författare)
- Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany
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- Send, Tabea (författare)
- Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany
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- Breton, Carrie (författare)
- Department of Population and Public Health Science, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
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- Bakulski, Kelly M. (författare)
- Department of Epidemiology, School of Public Health, University of Michigan, MI, Ann Arbor, United States
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- Fallin, M. Daniele (författare)
- Dean's Office, Rollins School of Public Health, Emory University, GA, Atlanta, United States
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- Schmidt, Rebecca J. (författare)
- Department of Public Health Sciences and the M.I.N.D. Institute, School of Medicine, University of California, CA, Davis, United States
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- Stein, Dan J. (författare)
- Neuroscience Institute, University of Cape Town, Cape Town, South Africa; Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa; South African Medical Research Council (SAMRC) Unit on Risk and Resilience in Mental Disorders, University of Cape Town, Cape Town, South Africa
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- Zar, Heather J. (författare)
- South African Medical Research Council (SAMRC) Unit on Risk and Resilience in Mental Disorders, University of Cape Town, Cape Town, South Africa; Department of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital, University of Cape Town, Cape Town, South Africa
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- Jaddoe, Vincent W. V. (författare)
- Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands; Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands
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- Wright, John (författare)
- Bradford Institute for Health Research, Temple Bank House, Bradford Royal Infirmary, Bradford, United Kingdom
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- Grazuleviciene, Regina (författare)
- Department of Environmental Sciences, Vytautas Magnus University, Kaunas, Lithuania
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- Gutzkow, Kristine Bjerve (författare)
- Division of Climate and Environmental Health, Norwegian Institute of Public Health, Oslo, Norway
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- Sunyer, Jordi (författare)
- ISGlobal, Institute for Global Health, Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; IMIM-Parc Salut Mar, Barcelona, Spain
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- Huels, Anke (författare)
- Department of Epidemiology, Rollins School of Public Health, Emory University, GA, Atlanta, United States; Gangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, GA, Atlanta, United States
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- Vrijheid, Martine (författare)
- ISGlobal, Institute for Global Health, Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain
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- Harlid, Sophia, 1978- (författare)
- Umeå universitet,Institutionen för diagnostik och intervention,Onkologi
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- London, Stephanie (författare)
- Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, Durham, United States
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- Hivert, Marie-France (författare)
- Division of Chronic Disease Research across the Lifecourse (CoRAL); Department of Population Medicine, Harvard Medical School, Harvard Pilgrim Health Care Institute, MA, Boston, United States; Diabetes Unit, Massachusetts General Hospital, MA, Boston, United States
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- Felix, Janine (författare)
- Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands; Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands
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- Bustamante, Mariona (författare)
- ISGlobal, Institute for Global Health, Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain
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- Guan, Weihua (författare)
- Division of Biostatistics, School of Public Health, University of Minnesota, MN, Minneapolis, United States
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Epidemiology Branch, Division of Population Health Research, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, MD, Bethesda, United States Division of Intramural Research, Glotech Inc, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, MD, Bethesda, United States (creator_code:org_t)
- 2024
- 2024
- Engelska.
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Ingår i: Aging Cell. - : John Wiley & Sons. - 1474-9718 .- 1474-9726.
- Relaterad länk:
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Worldwide trends to delay childbearing have increased parental ages at birth. Older parental age may harm offspring health, but mechanisms remain unclear. Alterations in offspring DNA methylation (DNAm) patterns could play a role as aging has been associated with methylation changes in gametes of older individuals. We meta-analyzed epigenome-wide associations of parental age with offspring blood DNAm of over 9500 newborns and 2000 children (5–10 years old) from the Pregnancy and Childhood Epigenetics consortium. In newborns, we identified 33 CpG sites in 13 loci with DNAm associated with maternal age (PFDR < 0.05). Eight of these CpGs were located near/in the MTNR1B gene, coding for a melatonin receptor. Regional analysis identified them together as a differentially methylated region consisting of 9 CpGs in/near MTNR1B, at which higher DNAm was associated with greater maternal age (PFDR = 6.92 × 10−8) in newborns. In childhood blood samples, these differences in blood DNAm of MTNR1B CpGs were nominally significant (p < 0.05) and retained the same positive direction, suggesting persistence of associations. Maternal age was also positively associated with higher DNA methylation at three CpGs in RTEL1-TNFRSF6B at birth (PFDR < 0.05) and nominally in childhood (p < 0.0001). Of the remaining 10 CpGs also persistent in childhood, methylation at cg26709300 in YPEL3/BOLA2B in external data was associated with expression of ITGAL, an immune regulator. While further study is needed to establish causality, particularly due to the small effect sizes observed, our results potentially support offspring DNAm as a mechanism underlying associations of maternal age with child health.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
Nyckelord
- aging
- child
- DNA methylation
- melatonin
- receptor
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- ref (ämneskategori)
- art (ämneskategori)
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Yeung, Edwina
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Biedrzycki, Rich ...
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Gómez Herrera, L ...
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Issarapu, Pracha ...
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Dou, John
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Marques, Irene F ...
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visa fler...
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Mansuri, Sohail ...
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Page, Christian ...
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Harbs, Justin
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Khodasevich, Den ...
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Poisel, Eric
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Niu, Zhongzheng
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Allard, Catherin ...
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Casey, Emma
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Berstein, Fernan ...
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Mancano, Giulia
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Elliott, Hannah ...
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Richmond, Rebecc ...
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He, Yiyan
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Ronkainen, Justi ...
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Sebert, Sylvain
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Bell, Erin M.
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Sharp, Gemma
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Mumford, Sunni L ...
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Schisterman, Enr ...
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Chandak, Giriraj ...
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Fall, Caroline H ...
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Sahariah, Sirazu ...
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Silver, Matt J.
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Prentice, Andrew ...
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Bouchard, Luigi
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Domellöf, Magnus ...
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West, Christina ...
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Holland, Nina
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Cardenas, Andres
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Eskenazi, Brenda
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Zillich, Lea
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Witt, Stephanie ...
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Send, Tabea
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Breton, Carrie
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Bakulski, Kelly ...
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Fallin, M. Danie ...
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Schmidt, Rebecca ...
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Stein, Dan J.
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Zar, Heather J.
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Jaddoe, Vincent ...
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Wright, John
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Grazuleviciene, ...
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Gutzkow, Kristin ...
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Sunyer, Jordi
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Huels, Anke
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Vrijheid, Martin ...
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Harlid, Sophia, ...
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London, Stephani ...
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Hivert, Marie-Fr ...
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Felix, Janine
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Bustamante, Mari ...
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Guan, Weihua
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Pediatrik
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Aging Cell
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Umeå universitet