| 1. |
- Kanis, J A, et al.
(författare)
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A meta-analysis of previous fracture and subsequent fracture risk.
- 2004
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Ingår i: Bone. - : Elsevier BV. - 8756-3282 .- 1873-2763. ; 35:2, s. 375-82
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Tidskriftsartikel (refereegranskat)abstract
- Previous fracture is a well-documented risk factor for future fracture. The aim of this study was to quantify this risk on an international basis and to explore the relationship of this risk with age, sex, and bone mineral density (BMD). We studied 15259 men and 44902 women from 11 cohorts comprising EVOS/EPOS, OFELY, CaMos, Rochester, Sheffield, Rotterdam, Kuopio, DOES, Hiroshima, and two cohorts from Gothenburg. Cohorts were followed for a total of 250000 person-years. The effect of a prior history of fracture on the risk of any fracture, any osteoporotic fracture, and hip fracture alone was examined using a Poisson model for each sex from each cohort. Covariates examined were age, sex, and BMD. The results of the different studies were merged by using the weighted beta-coefficients. A previous fracture history was associated with a significantly increased risk of any fracture compared with individuals without a prior fracture (RR = 1.86; 95% CI = 1.75-1.98). The risk ratio was similar for the outcome of osteoporotic fracture or for hip fracture. There was no significant difference in risk ratio between men and women. Risk ratio (RR) was marginally downward adjusted when account was taken of BMD. Low BMD explained a minority of the risk for any fracture (8%) and for hip fracture (22%). The risk ratio was stable with age except in the case of hip fracture outcome where the risk ratio decreased significantly with age. We conclude that previous history of fracture confers an increased risk of fracture of substantial importance beyond that explained by measurement of BMD. Its validation on an international basis permits the use of this risk factor in case finding strategies.
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| 2. |
- Brodeur, SR, et al.
(författare)
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C4b-binding protein (C4BP) activates B cells through the CD40 receptor
- 2003
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Ingår i: Immunity. - 1074-7613. ; 18:6, s. 837-848
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Tidskriftsartikel (refereegranskat)abstract
- We demonstrate that the a. chain of human C4b binding protein (C4BP) binds directly to CD40 on human B cells at a site that differs from that used by CD40 ligand. C4BP induces proliferation, upregulation of CD54 and CD86 expression, and IL4-dependent IgE isotype switching in normal B cells but not in B cells from patients with CD40 or IKKgamma/NEMO deficiencies. Furthermore, C4BP colocalized with B cells in the germinal centers of human tonsils. These observations suggest that C4BP is an activating ligand for CD40 and establish a novel interface between complement and B cell activation.
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| 3. |
- Larsson, Erik, et al.
(författare)
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Efficient test solutions for core-based designs
- 2004
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Ingår i: IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems. - 0278-0070 .- 1937-4151. ; 23:5, s. 758-775
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Tidskriftsartikel (refereegranskat)abstract
- A test solution for a complex system requires the design of a test access mechanism (TAM), which is used for the test data transportation, and a test schedule of the test data transportation on the designed TAM. An extensive TAM will lead to lower test-application time at the expense of higher routing costs, compared to a simple TAM with low routing cost but long testing time. It is also possible to reduce the testing time of a testable unit by loading the test vectors in parallel, thus increasing the parallelization of a test. However, such a test-time reduction often leads to higher power consumption, which must be kept under control since exceeding the power budget could damage the system under test. Furthermore, the execution of a test requires resources and concurrent execution of tests may not be possible due to resource or other conflicts. In this paper, we propose an integrated technique for test scheduling, test parallelization, and TAM design, where the test application time and the TAM routing are minimized, while considering test conflicts and power constraints. The main features of our technique are the efficiency in terms of computation time and the flexibility to model the system's test behavior, as well as the support for the testing of interconnections, unwrapped cores and user-defined logic. We have implemented our approach and made several experiments on benchmarks as well as industrial designs in order to demonstrate that our approach produces high-quality solution at low computational cost.
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