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Deficiency or inhib...
Deficiency or inhibition of Gas6 causes platelet dysfunction and protects mice against thrombosis
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Angelillo-Scherrer, Anne (author)
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- Garcia de Frutos, Pablo (author)
- Lund University,Lunds universitet,Klinisk kemi, Malmö,Forskargrupper vid Lunds universitet,Clinical Chemistry, Malmö,Lund University Research Groups
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Aparicio, Cristina (author)
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Melis, Els (author)
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Savi, Pierre (author)
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Lupu, Florea (author)
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Arnout, Jef (author)
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Dewerchin, Mieke (author)
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Hoylaerts, Marc F. (author)
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Herbert, Jean-Marc (author)
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Collen, Désiré (author)
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- Dahlbäck, Björn (author)
- Lund University,Lunds universitet,Klinisk kemi, Malmö,Forskargrupper vid Lunds universitet,Clinical Chemistry, Malmö,Lund University Research Groups
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Carmeliet, Peter (author)
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(creator_code:org_t)
- 2001-02-01
- 2001
- English.
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In: Nature Medicine. - : Springer Science and Business Media LLC. - 1546-170X .- 1078-8956. ; 7:2, s. 215-221
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Subject headings
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- The growth arrest-specific gene 6 product (Gas6) is a secreted protein related to the anticoagulant protein S but its role in hemostasis is unknown. Here we show that inactivation of the Gas6 gene prevented venous and arterial thrombosis in mice, and protected against fatal collagen/epinephrine-induced thrombo embolism. Gas6-/- mice did not, however, suffer spontaneous bleeding and had normal bleeding after tail clipping. In addition, we found that Gas6 antibodies inhibited platelet aggregation in vitro and protected mice against fatal thrombo embolism without causing bleeding in vivo. Gas6 amplified platelet aggregation and secretion in response to known agonists. Platelet dysfunction in Gas6-/- mice resembled that of patients with platelet signaling transduction defects. Thus, Gas6 is a platelet-response amplifier that plays a significant role in thrombosis. These findings warrant further evaluation of the possible therapeutic use of Gas6 inhibition for prevention of thrombosis.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Läkemedelskemi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medicinal Chemistry (hsv//eng)
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Angelillo-Scherr ...
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Garcia de Frutos ...
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Aparicio, Cristi ...
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Melis, Els
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Savi, Pierre
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Lupu, Florea
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show more...
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Arnout, Jef
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Dewerchin, Mieke
-
Hoylaerts, Marc ...
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Herbert, Jean-Ma ...
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Collen, Désiré
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Dahlbäck, Björn
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Carmeliet, Peter
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medicinal Chemis ...
- Articles in the publication
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Nature Medicine
- By the university
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Lund University