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- Soranzo, Nicole, et al.
(författare)
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A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium
- 2009
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 41:11, s. 38-1182
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Tidskriftsartikel (refereegranskat)abstract
- The number and volume of cells in the blood affect a wide range of disorders including cancer and cardiovascular, metabolic, infectious and immune conditions. We consider here the genetic variation in eight clinically relevant hematological parameters, including hemoglobin levels, red and white blood cell counts and platelet counts and volume. We describe common variants within 22 genetic loci reproducibly associated with these hematological parameters in 13,943 samples from six European population-based studies, including 6 associated with red blood cell parameters, 15 associated with platelet parameters and 1 associated with total white blood cell count. We further identified a long-range haplotype at 12q24 associated with coronary artery disease and myocardial infarction in 9,479 cases and 10,527 controls. We show that this haplotype demonstrates extensive disease pleiotropy, as it contains known risk loci for type 1 diabetes, hypertension and celiac disease and has been spread by a selective sweep specific to European and geographically nearby populations.
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| 4. |
- Goodall, R., et al.
(författare)
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Generalised symmetries and the ermakov-lewis invariant
- 2005
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Ingår i: Journal of Nonlinear Mathematical Physics. - : Atlantis Press. - 1402-9251 .- 1776-0852. ; 12:1, s. 15-26
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Generalised symmetries and point symmetries coincide for systems of first-order ordinary differential equations and are infinite in number. Systems of linear first-order ordinary differential equations possess a generalised rescaling symmetry. For the system of first-order ordinary differential equations corresponding to the time-dependent linear oscillator the invariant of this symmetry has the form of the famous Ermakov-Lewis invariant, but in fact reveals a richer structure. © 2005 Taylor & Francis Group, LLC.
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| 5. |
- Mosca, Andrea, et al.
(författare)
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Global standardization of glycated hemoglobin measurement: the position of the IFCC Working Group
- 2007
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Ingår i: Clinical Chemistry and Laboratory Medicine. - 1434-6621. ; 45:8, s. 1077-1080
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Tidskriftsartikel (refereegranskat)abstract
- The measurement of glycated hemoglobin is central in the monitoring of glycemic control in patients with diabetes. There are at least 30 different laboratory assays commercially available to measure the proportion of HbA1c in blood. In 1995 the IFCC established a Working Group (IFCC WG-HbA1c) to achieve international standardization of HbA1c measurement. The main achievements can be summarized as follows: a) a reference measurement procedure has been established with purified primary calibrators; b) a network of reference laboratories has been developed worldwide; and c) work has begun on implementation of traceability to the IFCC reference system. The IFCC WG-HbA1c recognizes the recommendation of the IFCC-IUPAC Committee on Nomenclature, Properties and Units that the analyte measured by the IFCC reference measurement procedure has been defined as beta N1-deoxyfructosyl-hemoglobin and that the recommended measurement units are mmol/mol. The IFCC WG-HbA1c recommends maintaining the use of the name HbA1c in clinical practice.
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