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Blood eosinophil co...
Blood eosinophil count and airway epithelial transcriptome relationships in COPD versus asthma
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- George, Leena (author)
- Univ Leicester, Leicester NIHR Biomed Res Ctr, Inst Lung Hlth, Leicester, Leics, England
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- Taylor, Adam R. (author)
- GSK Resp Therapeut Area Unit, Stevenage, Herts, England
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- Esteve-Codina, Anna (author)
- Barcelona Inst Sci & Technol, CNAG CRG Ctr Nacl Anal Genom, Ctr Genom Regulat, Barcelona, Spain
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- Soler Artigas, Maria (author)
- Univ Leicester, Leicester NIHR Biomed Res Ctr, Inst Lung Hlth, Leicester, Leics, England;Barcelona Inst Sci & Technol, CNAG CRG Ctr Nacl Anal Genom, Ctr Genom Regulat, Barcelona, Spain;Univ Autonoma Barcelona, VHIR, Grp Psychiat Mental Hlth & Addict, Psychiat Genet Unit, Barcelona, Spain;Biomed Network Res Ctr Mental Hlth CIBERSAM, Inst Salud Carlos III, Barcelona, Spain
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- Andri Thun, Gian (author)
- Barcelona Inst Sci & Technol, CNAG CRG Ctr Nacl Anal Genom, Ctr Genom Regulat, Barcelona, Spain
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- Bates, Stewart (author)
- GSK Resp Therapeut Area Unit, Stevenage, Herts, England
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- Pavlidis, Stelios (author)
- Imperial Coll London, Airway Dis Sect, Natl Heart & Lung Inst, London, England;Imperial Coll London, Data Sci Inst, London, England
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- Wagers, Scott (author)
- Biosci Consulting, Maasmechelen, Belgium
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- Boland, Anne (author)
- CEA, CNG Ctr Natl Genotypage, Inst Genom, Evry, France
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- Prasse, Antje (author)
- Univ Med Ctr, Dept Pneumol, Freiburg, Germany
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- Boschetto, Piera (author)
- Univ Ferrara, Dept Med Sci, Ferrara, Italy;Ferrara City Hosp, Ferrara, Italy
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- Parr, David G. (author)
- Univ Hosp Coventry & Warwickshire NHS Trust, Dept Resp Med, Coventry, W Midlands, England
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- Nowinski, Adam (author)
- Natl Inst TB & Lung Dis, Dept Resp Med, Warsaw, Poland
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- Barta, Imre (author)
- Natl Koranyi Inst TB & Pulmonol, Dept Pathophysiol, Budapest, Hungary
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- Hohlfeld, Jens (author)
- Fraunhofer Inst Toxicol & Expt Med, Hannover, Germany
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- Greulich, Timm (author)
- Philipps Univ Marburg, Univ Med Ctr Giessen & Marburg, Dept Med Pulm & Crit Care Med, Marburg, Germany;German Ctr Lung Res DZL, Grosshansdorf, Germany
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- van den Berge, Maarten (author)
- Univ Groningen, Univ Med Ctr Groningen, Dept Pulm Dis, Groningen, Netherlands
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- Hiemstra, Pieter S. (author)
- Leiden Univ, Med Ctr, Dept Pulm Dis, Leiden, Netherlands
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- Timens, Wim (author)
- Univ Groningen, Univ Med Ctr Groningen, Dept Pathol & Med Biol, Groningen, Netherlands
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- Hinks, Timothy (author)
- Univ Oxford, Oxford, England
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- Wenzel, Sally (author)
- Univ Pittsburgh, Dept Med, Pittsburgh, PA USA;Univ Pittsburgh, Dept Immunol, Pittsburgh, PA USA
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- Siddiqui, Salman (author)
- Univ Leicester, Leicester NIHR Biomed Res Ctr, Inst Lung Hlth, Leicester, Leics, England
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- Richardson, Matthew (author)
- Univ Leicester, Leicester NIHR Biomed Res Ctr, Inst Lung Hlth, Leicester, Leics, England
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- Venge, Per (author)
- Uppsala universitet,Klinisk kemi
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- Heath, Simon (author)
- Barcelona Inst Sci & Technol, CNAG CRG Ctr Nacl Anal Genom, Ctr Genom Regulat, Barcelona, Spain
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- Gut, Ivo (author)
- Barcelona Inst Sci & Technol, CNAG CRG Ctr Nacl Anal Genom, Ctr Genom Regulat, Barcelona, Spain;Univ Pompeu Fabra, Barcelona, Spain
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- Tobin, Martin D. (author)
- Univ Leicester, Leicester NIHR Biomed Res Ctr, Inst Lung Hlth, Leicester, Leics, England
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- Edwards, Lindsay (author)
- GSK Resp Therapeut Area Unit, Stevenage, Herts, England
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- Riley, John H. (author)
- GSK Resp Therapeut Area Unit, Stevenage, Herts, England
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- Djukanovic, Ratko (author)
- NIHR Southampton Resp Biomed Res Unit & Clin & Ex, Southampton, Hants, England
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- Auffray, Charles (author)
- Univ Lyon, EISBM, CNRS, ENS,UCBL, Lyon 07, France
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- De-Meulder, Bertrand (author)
- Univ Lyon, EISBM, CNRS, ENS,UCBL, Lyon 07, France
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- Erik-Dahlen, Sven (author)
- Karolinska Inst, Stockholm, Sweden
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- Adcock, Ian M. (author)
- Biomed Network Res Ctr Mental Hlth CIBERSAM, Inst Salud Carlos III, Barcelona, Spain
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- Chung, Kian Fan (author)
- Biomed Network Res Ctr Mental Hlth CIBERSAM, Inst Salud Carlos III, Barcelona, Spain
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- Ziegler-Heitbrock, Loems (author)
- Helmholtz Zentrum Muenchen, EvA Study Ctr, Gauting, Germany;Asklepios Klin, Gauting, Germany
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- Sterk, Peter J. (author)
- Univ Amsterdam, Med Ctr, Dept Resp Med, Amsterdam, Netherlands
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- Singh, Dave (author)
- Univ Manchester, Ctr Resp Med & Allergy, Manchester, Lancs, England;Univ Hosp South Manchester NHS Fdn Trust, Med Evaluat Unit, Manchester, Lancs, England
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- Brightling, Christopher E. (author)
- Univ Leicester, Leicester NIHR Biomed Res Ctr, Inst Lung Hlth, Leicester, Leics, England
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(creator_code:org_t)
- 2019-09-10
- 2020
- English.
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In: Allergy. European Journal of Allergy and Clinical Immunology. - : WILEY. - 0105-4538 .- 1398-9995. ; 75:2, s. 370-380
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Abstract
Subject headings
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- Background: Whether the clinical or pathophysiologic significance of the "treatable trait" high blood eosinophil count in COPD is the same as for asthma remains controversial. We sought to determine the relationship between the blood eosinophil count, clinical characteristics and gene expression from bronchial brushings in COPD and asthma.Methods: Subjects were recruited into a COPD (emphysema versus airway disease [EvA]) or asthma cohort (Unbiased BIOmarkers in PREDiction of respiratory disease outcomes, U-BIOPRED). We determined gene expression using RNAseq in EvA (n = 283) and Affymetrix microarrays in U-BIOPRED (n = 85). We ran linear regression analysis of the bronchial brushings transcriptional signal versus blood eosinophil counts as well as differential expression using a blood eosinophil > 200 cells/mu L as a cut-off. The false discovery rate was controlled at 1% (with continuous values) and 5% (with dichotomized values).Results: There were no differences in age, gender, lung function, exercise capacity and quantitative computed tomography between eosinophilic versus noneosinophilic COPD cases. Total serum IgE was increased in eosinophilic asthma and COPD. In EvA, there were 12 genes with a statistically significant positive association with the linear blood eosinophil count, whereas in U-BIOPRED, 1197 genes showed significant associations (266 positive and 931 negative). The transcriptome showed little overlap between genes and pathways associated with blood eosinophil counts in asthma versus COPD. Only CST1 was common to eosinophilic asthma and COPD and was replicated in independent cohorts.Conclusion: Despite shared "treatable traits" between asthma and COPD, the molecular mechanisms underlying these clinical entities are predominately different.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Keyword
- asthma
- chronic obstructive pulmonary disease
- eosinophil
- gene expression
- T2-immunity
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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George, Leena
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Taylor, Adam R.
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Esteve-Codina, A ...
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Soler Artigas, M ...
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Andri Thun, Gian
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Bates, Stewart
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show more...
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Pavlidis, Stelio ...
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Wagers, Scott
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Boland, Anne
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Prasse, Antje
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Boschetto, Piera
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Parr, David G.
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Nowinski, Adam
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Barta, Imre
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Hohlfeld, Jens
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Greulich, Timm
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van den Berge, M ...
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Hiemstra, Pieter ...
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Timens, Wim
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Hinks, Timothy
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Wenzel, Sally
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Siddiqui, Salman
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Richardson, Matt ...
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Venge, Per
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Heath, Simon
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Gut, Ivo
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Tobin, Martin D.
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Edwards, Lindsay
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Riley, John H.
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Djukanovic, Ratk ...
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Auffray, Charles
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De-Meulder, Bert ...
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Erik-Dahlen, Sve ...
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Adcock, Ian M.
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Chung, Kian Fan
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Ziegler-Heitbroc ...
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Sterk, Peter J.
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Singh, Dave
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Brightling, Chri ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Respiratory Medi ...
- Articles in the publication
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Allergy. Europea ...
- By the university
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Uppsala University
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Karolinska Institutet