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Sökning: (WFRF:(Hassan B)) srt2:(2005-2009) > (2006)

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  • Freidovich, Leonid B., et al. (författare)
  • Robust feedback linearization using extended high-gain observers
  • 2006
  • Ingår i: 45th IEEE Conference onDecision and Control. - New York : IEEE. - 1424401712 ; , s. 983-988
  • Konferensbidrag (refereegranskat)abstract
    • We consider a partially feedback linearizable system with stable zero dynamics. The system is uncertain and only the output is measured. Consequently, exact feedback linearization is not applicable. We propose to design an extended high-gain observer to recover unmeasured derivatives of the output and an extra one, which contains information about the uncertainty. The observer can be stabilized via feedback linearization followed by a linear control design, such as pole placement or LQR. After a short peaking period, a partial state vector, which includes the output and its derivatives, will be in a small neighborhood of the state of the observer; therefore, the performance achievable under exact feedback linearization will be recovered.
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  • Hassan, Saadia B., et al. (författare)
  • CHS 828 kill tumour cells by inhibiting the nuclear factor-kappa B translocation but unlikely through down-regulation of proteasome
  • 2006
  • Ingår i: Anticancer Research. - 0250-7005 .- 1791-7530. ; 26:6B, s. 4431-4436
  • Tidskriftsartikel (refereegranskat)abstract
    • CHS 828 (N-(6-chlorophenoxyhexyl)-N'cyano-N"-4-pyridylguanidine) has shown promising activity in many preclinical systems and in phase I/II clinical trials. The nuclear transcription factor kappa B (NF-κB) has been identified as a target for CHS 828. The aim of this study was to confirm the inhibitory effect of CHS 828 on NF-κB translocation and to explore its possible effect on the proteasome using 7 cell lines. Translocation of NF-κB from the cytoplasm to the nucleus was analysed using a quantitative cytometric system, ArrayScan®. The activity of the proteasome was assayed by monitoring the hydrolysis of a fluorogenic substrate. In parallel, the in vitro cytotoxic effect of CHS 828 was analyzed using a 72-h microtiter plate-based cytotoxicity assay (FMCA). CHS 828 inhibited NF-κB translocation in the cell lines where it was able to inhibit the tumour cell growth. However, the results did not prove any effect of CHS 828 on proteasome activity when compared to a proteasome inhibitor activity.
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