| 1. |
- Varjupuro, R., et al.
(författare)
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Challenges for the Holistic management of Eutrophication and Cod Fisheries in the Baltic Sea
- 2011
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- The current deliverable (D7.1.) aims to review the challenges of the established policies for providing a holistic ecosystem approach for management of the inter-linked environmental problems in the Baltic Sea Region.Based on the review of the issues that are of major concern, as well as the recent scientific knowledge of the ecological coupling of eutrophication, changes in the food web structure and decline of the cod stocks (e.g. Mällman et al. 2008, Österblom et al. 2010), we decided to focus our analysis on the two inter-linked problems of eutrophication and cod fisheries.In this report, we briefly describe the ecosystem of the Baltic Sea as well as the nature of these two environmental issues. We provide an overview of major environmental policies that are governing these two inter-linked problems. We also discuss the current challenges in the implementation of these established policies in the context of requirements for holistic ecosystem based management of the Baltic Sea.
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| 2. |
- Zor, K., et al.
(författare)
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A compact multifunctional microfluidic platform for exploring cellular dynamics in real-time using electrochemical detection
- 2014
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Ingår i: RSC Advances. - : Royal Society of Chemistry (RSC). - 2046-2069. ; 4:109, s. 63761-63771
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Tidskriftsartikel (refereegranskat)abstract
- Downscaling of microfluidic cell culture and detection devices for electrochemical monitoring has mostly focused on miniaturization of the microfluidic chips which are often designed for specific applications and therefore lack functional flexibility. We present a compact microfluidic cell culture and electrochemical analysis platform with in-built fluid handling and detection, enabling complete cell based assays comprising on-line electrode cleaning, sterilization, surface functionalization, cell seeding, cultivation and electrochemical real-time monitoring of cellular dynamics. To demonstrate the versatility and multifunctionality of the platform, we explored amperometric monitoring of intracellular redox activity in yeast (Saccharomyces cerevisiae) and detection of exocytotically released dopamine from rat pheochromocytoma cells (PC12). Electrochemical impedance spectroscopy was used in both applications for monitoring cell sedimentation and adhesion as well as proliferation in the case of PC12 cells. The influence of flow rate on the signal amplitude in the detection of redox metabolism as well as the effect of mechanical stimulation on dopamine release were demonstrated using the programmable fluid handling capability. The here presented platform is aimed at applications utilizing cell based assays, ranging from e.g. monitoring of drug effects in pharmacological studies, characterization of neural stem cell differentiation, and screening of genetically modified microorganisms to environmental monitoring.
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