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Long-Term Outcome o...
Long-Term Outcome of Inflammatory Breast Cancer Compared to Non-Inflammatory Breast Cancer in the Setting of High-Dose Chemotherapy with Autologous Hematopoietic Cell Transplantation
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- Cheng, Yee Chung (författare)
- Med Coll Wisconsin, Milwaukee, WI 53226 USA
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- Shi, Yushu (författare)
- Med Coll Wisconsin, Milwaukee, WI 53226 USA.
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- Zhang, Mei-Jie (författare)
- Med Coll Wisconsin, Milwaukee, WI 53226 USA.;Med Coll Wisconsin, Milwaukee, WI 53226 USA.
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- Brazauskas, Ruta (författare)
- Med Coll Wisconsin, Milwaukee, WI 53226 USA.
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- Hemmer, Michael T. (författare)
- Med Coll Wisconsin, Milwaukee, WI 53226 USA.
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- Bishop, Michael R. (författare)
- Univ Chicago Hosp, Chicago, IL 60637 USA.
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- Nieto, Yago (författare)
- Univ Texas, Houston, TX 77030 USA.
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- Stadtmauer, Edward (författare)
- Univ Penn, Philadelphia, PA 19104 USA.
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- Ayash, Lois (författare)
- Karmanos Canc Inst, Detroit, MI USA.;Univ Minnesota, Minneapolis, MN 55455 USA.
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- Gale, Robert Peter (författare)
- Imperial Coll London, London, England.
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- Lazarus, Hillard (författare)
- Univ Hosp, Cleveland, OH USA.
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- Holmberg, Leona (författare)
- Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA.
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- Lill, Michael (författare)
- Cedars Sinai Med Ctr, Los Angeles, CA 90048 USA.
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- Olsson, R (författare)
- Karolinska Institutet,Uppsala universitet,Centrum för klinisk forskning i Sörmland (CKFD),Karolinska Inst, Stockholm, Sweden.
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- Wirk, Baldeep Mona (författare)
- Seattle Canc Care Alliance, Seattle, WA USA.
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- Arora, Mukta (författare)
- Univ Minnesota, Minneapolis, MN 55455 USA.
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- Hari, Parameswaran (författare)
- Med Coll Wisconsin, Milwaukee, WI 53226 USA.
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- Ueno, Naoto (författare)
- Univ Texas, Houston, TX 77030 USA.
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Med Coll Wisconsin, Milwaukee, WI 53226 USA Med Coll Wisconsin, Milwaukee, WI 53226 USA (creator_code:org_t)
- IVYSPRING INT PUBL, 2017
- 2017
- Engelska.
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Ingår i: Journal of Cancer. - : IVYSPRING INT PUBL. - 1837-9664. ; 8:6, s. 1009-1017
- Relaterad länk:
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https://uu.diva-port... (primary) (Raw object)
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https://www.jcancer....
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https://urn.kb.se/re...
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https://doi.org/10.7...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Introduction: Inflammatory breast cancer (IBC) is a rare aggressive form of breast cancer. It is well known that the long-term survival and progression-free survival of IBC are worse than that of non-IBC. We report the long term outcomes of patients with IBC and non-IBC who had undergone high-dose chemotherapy (HDC) with autologous hematopoietic cell transplantation (AHCT).Methods: All 3387 patients with IBC or non-IBC who underwent HDC with AHCT between1990-2002 and registered with CIBMTR were included in this analysis. Transplant-related mortality (TRM), disease relapse/progression, progression-free survival (PFS) and overall survival (OS) were compared between the two cohorts. Multivariate Cox regression model was used to determine the independent impact of stage on outcomes.Results: 527 patients with IBC and 2,860 patients with non-IBC were included; the median age at transplantation (47 vs 46 years old) and median follow-up period in the 2 groups (167 vs 168 months) were similar. The most common conditioning regimen was cyclophosphamide and carboplatin based in both groups (54% in IBC and 50% in non-IBC). AHCT was well tolerated in both groups. TRM was similar in both groups (one year TRM was 2% for IBC and 3% for non-IBC, p= 0.16). The most common cause of death was disease progression or relapse (81% in IBC and 75% in non-IBC). The median survival for both IBC and non-IBC was the same at 40 months. The PFS at 10 years was 27% (95% CI: 23-31%) for IBC and 24% (95% CI: 22-26%) for non-IBC (p= 0.21), and the OS at 10 years was 31% (95% CI: 27-35%) for IBC and 28% (95% CI: 26-30%) for non-IBC (p= 0.16). In univariate analysis, patients with stage III IBC and no active diseases at transplantation had lower PFS and OS than that in non-IBC. In multivariate analysis, controlling for age, disease status at AHCT, hormonal receptor status, time from HR 1.16, 95% CI: 1- 1.34, p=0.0459), worse PFS (HR: 1.17, 95% CI: 1.01-1.36, p= 0.0339) and higher risk of disease relapse/progression (HR: 1.24, 95% CI: 1.06- 1.45, p= 0.0082) as compared to stage III non-IBC. Amongst all patients a higher stage disease was associated with worse PFS, OS and disease relapse/ progression.Conclusions: Long-term outcomes of stage III IBC patients who underwent AHCT were poorer than that in non-IBC patients confirming that the poor prognosis of IBC even in the setting of HDC with AHCT.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- Inflammatory Breast Cancer
- Hematopoietic Cell Transplantation
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- ref (ämneskategori)
- art (ämneskategori)
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Cheng, Yee Chung
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Shi, Yushu
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Zhang, Mei-Jie
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Brazauskas, Ruta
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Hemmer, Michael ...
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Bishop, Michael ...
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visa fler...
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Nieto, Yago
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Stadtmauer, Edwa ...
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Ayash, Lois
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Gale, Robert Pet ...
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Lazarus, Hillard
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Holmberg, Leona
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Lill, Michael
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Olsson, R
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Wirk, Baldeep Mo ...
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Arora, Mukta
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Hari, Parameswar ...
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Ueno, Naoto
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Uppsala universitet
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Karolinska Institutet