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Targeted sequencing...
Targeted sequencing in chromosome 17q linkage region identifies familial glioma candidates in the Gliogene Consortium
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Jalali, Ali (author)
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Amirian, E. Susan (author)
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Bainbridge, Matthew N. (author)
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Armstrong, Georgina N. (author)
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Liu, Yanhong (author)
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Tsavachidis, Spyros (author)
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Jhangiani, Shalini N. (author)
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Plon, Sharon E. (author)
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Lau, Ching C. (author)
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Claus, Elizabeth B. (author)
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Barnholtz-Sloan, Jill S. (author)
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Il'yasova, Dora (author)
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Schildkraut, Joellen (author)
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Ali-Osman, Francis (author)
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Sadetzki, Siegal (author)
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Johansen, Christoffer (author)
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Houlston, Richard S. (author)
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Jenkins, Robert B. (author)
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Lachance, Daniel (author)
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Olson, Sara H. (author)
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Bernstein, Jonine L. (author)
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Merrell, Ryan T. (author)
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Wrensch, Margaret R. (author)
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Davis, Faith G. (author)
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Lai, Rose (author)
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Shete, Sanjay (author)
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Aldape, Kenneth (author)
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Amos, Christopher I. (author)
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Muzny, Donna M. (author)
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Gibbs, Richard A. (author)
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- Melin, Beatrice S (author)
- Umeå universitet,Onkologi
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Bondy, Melissa L. (author)
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(creator_code:org_t)
- 2015-02-05
- 2015
- English.
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In: Scientific Reports. - : Nature Publishing Group. - 2045-2322. ; 5, s. 8278-
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https://umu.diva-por... (primary) (Raw object)
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https://www.nature.c...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Glioma is a rare, but highly fatal, cancer that accounts for the majority of malignant primary brain tumors. Inherited predisposition to glioma has been consistently observed within non-syndromic families. Our previous studies, which involved non-parametric and parametric linkage analyses, both yielded significant linkage peaks on chromosome 17q. Here, we use data from next generation and Sanger sequencing to identify familial glioma candidate genes and variants on chromosome 17q for further investigation. We applied a filtering schema to narrow the original list of 4830 annotated variants down to 21 very rare (<0.1% frequency), non-synonymous variants. Our findings implicate the MYO19 and KIF18B genes and rare variants in SPAG9 and RUNDC1 as candidates worthy of further investigation. Burden testing and functional studies are planned.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
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- ref (subject category)
- art (subject category)
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- By the author/editor
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Jalali, Ali
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Amirian, E. Susa ...
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Bainbridge, Matt ...
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Armstrong, Georg ...
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Liu, Yanhong
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Tsavachidis, Spy ...
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show more...
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Jhangiani, Shali ...
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Plon, Sharon E.
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Lau, Ching C.
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Claus, Elizabeth ...
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Barnholtz-Sloan, ...
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Il'yasova, Dora
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Schildkraut, Joe ...
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Ali-Osman, Franc ...
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Sadetzki, Siegal
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Johansen, Christ ...
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Houlston, Richar ...
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Jenkins, Robert ...
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Lachance, Daniel
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Olson, Sara H.
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Bernstein, Jonin ...
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Merrell, Ryan T.
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Wrensch, Margare ...
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Davis, Faith G.
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Lai, Rose
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Shete, Sanjay
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Aldape, Kenneth
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Amos, Christophe ...
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Muzny, Donna M.
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Gibbs, Richard A ...
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Melin, Beatrice ...
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Bondy, Melissa L ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
- Articles in the publication
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Scientific Repor ...
- By the university
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Umeå University