Search: (WFRF:(Hu Jianhong))
> (2013) >
Prevalence and asso...
Prevalence and associated metabolic factors of fatty liver disease in the elderly
-
Wang, Zhongli (author)
-
Xu, Ming (author)
-
Peng, Jianhong (author)
-
show more...
-
Jiang, Li (author)
-
Hu, Zhengguo (author)
-
Wang, Hua (author)
-
Zhou, Shiqing (author)
-
Zhou, Rui (author)
-
- Hultström, Michael, 1978- (author)
- Uppsala universitet,Integrativ Fysiologi
-
Lai, En Yin (author)
-
show less...
-
(creator_code:org_t)
- Elsevier BV, 2013
- 2013
- English.
-
In: Experimental Gerontology. - : Elsevier BV. - 0531-5565 .- 1873-6815. ; 48:8, s. 705-709
- Related links:
-
https://urn.kb.se/re...
-
show more...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- OBJECTIVE: The aim of this study was to investigate the metabolic risk factors for fatty liver disease in the elderly, and determine the prevalence of fatty liver disease in the elderly in Wuhan, central China.METHODS: The study was a case-control study based on all 4226 adults above 60years of age from a cohort investigated in 2010-11 at the medical examination center of Zhongnan hospital, using 3145 randomly selected adults under 60years of age from the same cohort as controls. Fatty liver disease (FLD) was identified with ultrasound imaging. The risk factors measured were body mass index (BMI), and plasma concentrations of alanine aminotransferase (ALT), aspartate aminotransferase (AST), total cholesterol (TC), triglyceride (TG), high-density lipoprotein (HDL), low density lipoprotein (LDL) and serum uric acid (SUA). The probability of steatohepatitis with advanced fibrosis was predicted using a score based on BMI, age, ALT, and TG (BAAT),and using AST/ALT ratio (AAR).RESULTS: FLD was higher in the elderly (26.7%) than in the non-elderly (22.8%) and similar in the elderly between men and women (26.6% vs 27.0%, p>0.05). BMI, TC, TG, LDL, SUA, AST and ALT were all significantly higher in FLD, whereas the level of HDL was markedly lower. Multiple regression analyses showed that obesity, high TC, TG, SUA, low HDL, and elevated ALT, AAR<1 were closely related to the elderly FLD, while male sex, obesity, high TC, TG, low HDL, elevated ALT, AST and AAR<1 were closely related to the non-elderly FLD. The prevalence of steatohepatitis with advanced fibrosis estimated as BAAT index≥3 was 2.4% in all subjects, and was higher in the elderly FLD patients than in the non-elderly FLD patients.CONCLUSION: The prevalence of FLD is higher in the elderly, and is broadly related to the same metabolic risk factors as in the non-elderly. However, female-sex is no longer protective with increasing age, and the prevalence of steatohepatitis with advanced fibrosis is estimated to be considerably higher in the elderly FLD patients than in the non-elderly FLD controls.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Wang, Zhongli
-
Xu, Ming
-
Peng, Jianhong
-
Jiang, Li
-
Hu, Zhengguo
-
Wang, Hua
-
show more...
-
Zhou, Shiqing
-
Zhou, Rui
-
Hultström, Micha ...
-
Lai, En Yin
-
show less...
- About the subject
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
and Klinisk medicin
-
and Gastroenterologi
- Articles in the publication
-
Experimental Ger ...
- By the university
-
Uppsala University