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NMDA Receptor Antib...
NMDA Receptor Antibodies and Neuropsychiatric Symptoms in Parkinson's Disease.
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Gibson, Lucy L (författare)
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Pollak, Thomas A (författare)
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Hart, Melanie (författare)
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Heslegrave, Amanda (författare)
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Hye, Abdul (författare)
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Church, Andrew J (författare)
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Lakdawala, Neghat (författare)
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Nicholson, Timothy R (författare)
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Batzu, Lucia (författare)
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Rota, Silvia (författare)
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Trivedi, Dhaval (författare)
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- Zetterberg, Henrik, 1973 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Chaudhuri, Kallol Ray (författare)
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- Aarsland, Dag (författare)
- Karolinska Institutet
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(creator_code:org_t)
- 2023-01-30
- 2023
- Engelska.
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Ingår i: The Journal of neuropsychiatry and clinical neurosciences. - : American Psychiatric Association Publishing. - 1545-7222 .- 0895-0172. ; 35:3, s. 236-243
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- N-methyl-d-aspartate receptor (NMDAR) encephalitis is an autoantibody-mediated neurological syndrome with prominent cognitive and neuropsychiatric symptoms. The clinical relevance of NMDAR antibodies outside the context of encephalitis was assessed in this study.Plasma from patients with Parkinson's disease (PD) (N=108) and healthy control subjects (N=89) was screened at baseline for immunoglobulin A (IgA), IgM, and IgG NMDAR antibodies, phosphorylated tau 181 (p-tau181), and the neuroaxonal injury marker neurofilament light (NfL). Clinical assessment of the patients included measures of cognition (Mini-Mental State Examination [MMSE]) and neuropsychiatric symptoms (Hospital Anxiety and Depression Scale; Non-Motor Symptoms Scale for Parkinson's Disease). A subgroup of patients (N=61) was followed annually for up to 6 years.Ten (9%) patients with PD tested positive for NMDAR antibodies (IgA, N=5; IgM, N=6; IgG, N=0), and three (3%) healthy control subjects had IgM NMDAR antibodies; IgA NMDAR antibodies were detected significantly more commonly among patients with PD than healthy control subjects (χ2=4.23, df=1, p=0.04). Age, gender, and disease duration were not associated with NMDAR antibody positivity. Longitudinally, antibody-positive patients had significantly greater decline in annual MMSE scores when the analyses were adjusted for education, age, disease duration, p-tau181, NfL, and follow-up duration (adjusted R2=0.26, p=0.01). Neuropsychiatric symptoms were not associated with antibody status, and no associations were seen between NMDAR antibodies and p-tau181 or NfL levels.NMDAR antibodies were associated with greater cognitive impairment over time in patients with PD, independent of other pathological biomarkers, suggesting a potential contribution of these antibodies to cognitive decline in PD.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- Humans
- Parkinson Disease
- complications
- psychology
- Receptors
- N-Methyl-D-Aspartate
- Encephalitis
- Autoantibodies
- Immunoglobulin M
- Immunoglobulin A
- Immunoglobulin G
- Biomarkers
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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- Av författaren/redakt...
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Gibson, Lucy L
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Pollak, Thomas A
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Hart, Melanie
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Heslegrave, Aman ...
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Hye, Abdul
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Church, Andrew J
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visa fler...
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Lakdawala, Negha ...
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Nicholson, Timot ...
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Batzu, Lucia
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Rota, Silvia
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Trivedi, Dhaval
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Zetterberg, Henr ...
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Chaudhuri, Kallo ...
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Aarsland, Dag
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visa färre...
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Göteborgs universitet
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Karolinska Institutet