| 1. |
- Grieser, M., et al.
(author)
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Storage ring at HIE-ISOLDE Technical design report
- 2012
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In: The European Physical Journal Special Topics. - : Springer Science and Business Media LLC. - 1951-6355 .- 1951-6401. ; 207:1, s. 1-117
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Research review (peer-reviewed)abstract
- We propose to install a storage ring at an ISOL-type radioactive beam facility for the first time. Specifically, we intend to setup the heavy-ion, low-energy ring TSR at the HIE-ISOLDE facility in CERN, Geneva. Such a facility will provide a capability for experiments with stored secondary beams that is unique in the world. The envisaged physics programme is rich and varied, spanning from investigations of nuclear ground-state properties and reaction studies of astrophysical relevance, to investigations with highly-charged ions and pure isomeric beams. The TSR might also be employed for removal of isobaric contaminants from stored ion beams and for systematic studies within the neutrino beam programme. In addition to experiments performed using beams recirculating within the ring, cooled beams can also be extracted and exploited by external spectrometers for high-precision measurements. The existing TSR, which is presently in operation at the Max-Planck Institute for Nuclear Physics in Heidelberg, is well-suited and can be employed for this purpose. The physics cases as well as technical details of the existing ring facility and of the beam and infrastructure requirements at HIE-ISOLDE are discussed in the present technical design report.
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| 2. |
- Grieser, M., et al.
(author)
-
Storage ring at HIE-ISOLDE
- 2012
-
In: European Physical Journal: Special Topics. - : Springer Science and Business Media LLC. - 1951-6401 .- 1951-6355. ; 207:1, s. 1-117
-
Journal article (peer-reviewed)abstract
- We propose to install a storage ring at an ISOL-type radioactive beam facility for the first time. Specifically, we intend to setup the heavy-ion, low-energy ring TSR at the HIE-ISOLDE facility in CERN, Geneva. Such a facility will provide a capability for experiments with stored secondary beams that is unique in the world. The envisaged physics programme is rich and varied, spanning from investigations of nuclear ground-state properties and reaction studies of astrophysical relevance, to investigations with highly-charged ions and pure isomeric beams. The TSR might also be employed for removal of isobaric contaminants from stored ion beams and for systematic studies within the neutrino beam programme. In addition to experiments performed using beams recirculating within the ring, cooled beams can also be extracted and exploited by external spectrometers for high-precision measurements. The existing TSR, which is presently in operation at the Max-Planck Institute for Nuclear Physics in Heidelberg, is well-suited and can be employed for this purpose. The physics cases as well as technical details of the existing ring facility and of the beam and infrastructure requirements at HIE-ISOLDE are discussed in the present technical design report.
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| 3. |
- Bruce, A. M., et al.
(author)
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Beta Decay of 102Y Produced in Projectile Fission of 238U
- 2012
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In: Journal of Physics: Conference Series. - : IOP Publishing. - 1742-6596 .- 1742-6588. ; 381
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Journal article (peer-reviewed)abstract
- The population of 102Zr following the β decay of 102Y produced in the projectile fission of 238U at the GSI facility in Darmstadt, Germany has been studied. 102Y is known to ß decay into 102Zr via two states, one of high spin and the other low spin. These states preferentially populate different levels in the 102Zr daughter. In this paper the intensities of transitions in 102Zr observed are compared with those from the decay of the low-spin level studied at the TRISTAN facility at Brookhaven National Laboratory and of the high-spin level studied at the JOSEF separator at the Kernforschungsanlage Jülich.
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| 4. |
- Andresen, G. B., et al.
(author)
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The ALPHA-detector : Module Production and Assembly
- 2012
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In: Journal of Instrumentation. - 1748-0221. ; 7, s. C01051-
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Journal article (peer-reviewed)abstract
- ALPHA is one of the experiments situated at CERN's Antiproton Decelerator (AD). A Silicon Vertex Detector (SVD) is placed to surround the ALPHA atom trap. The main purpose of the SVD is to detect and locate antiproton annihilation events by means of the emitted charged pions. The SVD system is presented with special focus given to the design, fabrication and performance of the modules.
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| 5. |
- Giroud, C., et al.
(author)
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Integration of a radiative divertor for heat load control into JET high triangularity ELMy H-mode plasmas
- 2012
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In: Nuclear Fusion. - : IOP Publishing. - 0029-5515 .- 1741-4326. ; 52:6, s. 063022-
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Journal article (peer-reviewed)abstract
- Experiments on JET with a carbon-fibre composite wall have explored the reduction of steady-state power load in an ELMy H-mode scenario at high Greenwald fraction similar to 0.8, constant power and close to the L to H transition. This paper reports a systematic study of power load reduction due to the effect of fuelling in combination with seeding over a wide range of pedestal density ((4-8) x 10(19) m(-3)) with detailed documentation of divertor, pedestal and main plasma conditions, as well as a comparative study of two extrinsic impurity nitrogen and neon. It also reports the impact of steady-state power load reduction on the overall plasma behaviour, as well as possible control parameters to increase fuel purity. Conditions from attached to fully detached divertor were obtained during this study. These experiments provide reference plasmas for comparison with a future JET Be first wall and an all W divertor where the power load reduction is mandatory for operation.
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| 6. |
- Hobirk, J., et al.
(author)
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Improved confinement in JET hybrid discharges
- 2012
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In: Plasma Physics and Controlled Fusion. - : IOP Publishing. - 0741-3335 .- 1361-6587. ; 54:9, s. 095001-
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Journal article (peer-reviewed)abstract
- A new technique has been developed to produce plasmas with improved confinement relative to the H 98,y2 scaling law (ITER Physics Expert Groups on Confinement and Transport and Confinement Modelling and Database ITER Physics Basics Editors and ITER EDA 1999 Nucl. Fusion 39 2175) on the JET tokamak. In the mid-size tokamaks ASDEX upgrade and DIII-D heating during the current formation is used to produce a flat q-profile with a minimum close to 1. On JET this technique leads to q-profiles with similar minimum q but opposite to the other tokamaks not to an improved confinement state. By changing the method utilizing a faster current ramp with temporary higher current than in the flattop (current overshoot) plasmas with improved confinement (H 98,y2=1.35) and good stability (β N3) have been produced and extended to many confinement times only limited by technical constraints. The increase in H 98,y2-factor is stronger with more heating power as can be seen in a power scan. The q-profile development during the high power phase in JET is reproduced by current diffusion calculated by TRANSP and CRONOS. Therefore the modifications produced by the current overshoot disappear quickly from the edge but the confinement improvement lasts longer, in some cases up to the end of the heating phase.
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| 7. |
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| 8. |
- Mattsson, Niklas, 1979, et al.
(author)
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Reference measurement procedures for Alzheimer's disease cerebrospinal fluid biomarkers: definitions and approaches with focus on amyloid β42.
- 2012
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In: Biomarkers in medicine. - : Future Medicine Ltd. - 1752-0371 .- 1752-0363. ; 6:4, s. 409-17
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Journal article (peer-reviewed)abstract
- Cerebrospinal fluid (CSF) biomarkers for Alzheimer's disease (AD) are increasingly used in clinical settings, research and drug trials. However, their broad-scale use on different technology platforms is hampered by the lack of standardization at the level of sample handling, determination of concentrations of analytes and the absence of well-defined performance criteria for in vitro diagnostic or companion diagnostic assays, which influences the apparent concentration of the analytes measured and the subsequent interpretation of the data. There is a need for harmonization of CSF AD biomarker assays that can reliably, across centers, quantitate CSF biomarkers with high analytical precision, selectivity and stability over long time periods. In this position paper, we discuss reference procedures for the measurement of CSF AD biomarkers, especially amyloid β42 and tau. We describe possible technical approaches, focusing on a selected reaction monitoring mass spectrometry assay as a candidate reference method for quantification of CSF amyloid β42.
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| 9. |
- Rajaraman, Preetha, et al.
(author)
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Genome-wide association study of glioma and meta-analysis
- 2012
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In: Human Genetics. - : SPRINGER. - 0340-6717 .- 1432-1203. ; 131:12, s. 1877-1888
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Journal article (peer-reviewed)abstract
- Gliomas account for approximately 80 % of all primary malignant brain tumors and, despite improvements in clinical care over the last 20 years, remain among the most lethal tumors, underscoring the need for gaining new insights that could translate into clinical advances. Recent genome-wide association studies (GWAS) have identified seven new susceptibility regions. We conducted a new independent GWAS of glioma using 1,856 cases and 4,955 controls (from 14 cohort studies, 3 case-control studies, and 1 population-based case-only study) and found evidence of strong replication for three of the seven previously reported associations at 20q13.33 (RTEL), 5p15.33 (TERT), and 9p21.3 (CDKN2BAS), and consistent association signals for the remaining four at 7p11.2 (EGFR both loci), 8q24.21 (CCDC26) and 11q23.3 (PHLDB1). The direction and magnitude of the signal were consistent for samples from cohort and case-control studies, but the strength of the association was more pronounced for loci rs6010620 (20q,13.33; RTEL) and rs2736100 (5p15.33, TERT) in cohort studies despite the smaller number of cases in this group, likely due to relatively more higher grade tumors being captured in the cohort studies. We further examined the 85 most promising single nucleotide polymorphism (SNP) markers identified in our study in three replication sets (5,015 cases and 11,601 controls), but no new markers reached genome-wide significance. Our findings suggest that larger studies focusing on novel approaches as well as specific tumor subtypes or subgroups will be required to identify additional common susceptibility loci for glioma risk.
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| 10. |
- Wadsworth, R., et al.
(author)
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Spin-gap Isomer in 96Cd
- 2012
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In: Journal of Physics: Conference Series. - : IOP Publishing. - 1742-6596 .- 1742-6588. ; 381:1
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Journal article (peer-reviewed)abstract
- Evidence has been obtained for the existence of the long predicted 16+ spin-gap isomer in 96Cd. The decay of the isomer was identified and studied following the use of an 850 MeV/u beam of 124Xe impinging on a Be target and the fragment recoil separator at the GSI Laboratory. Gamma decays from the fragments were detected using the RISING gamma ray array, in its stopped beam configuration, plus a silicon active stopper. The data obtained have been compared with shell model predictions, which indicate that the isoscalar neutron-proton interaction plays a key role in the formation of the isomer.
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