| 1. |
- Abdallah, J., et al.
(författare)
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A study of b(b)over-bar production in e(+)e(-) collisions at root s=130-207 GeV
- 2009
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Ingår i: European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 60:1, s. 1-15
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Tidskriftsartikel (refereegranskat)abstract
- Measurements are presented of R-b, the ratio of the b (b) over bar cross-section to the q (q) over bar cross-section in e(+)e(-) collisions, and the forward-backward asymmetry A(FB)(b) at twelve energy points in the range root s = 130-207 GeV. These results are found to be consistent with the Standard Model expectations. The measurements are used to set limits on new physics scenarios involving contact interactions.
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| 2. |
- Buchmayer, Susanne, et al.
(författare)
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Can Association Between Preterm Birth and Autism be Explained by Maternal or Neonatal Morbidity?
- 2009
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Ingår i: Pediatrics. - : American Academy of Pediatrics (AAP). - 0031-4005 .- 1098-4275. ; 124:5, s. E817-E825
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: We examined whether an association between preterm birth and risk of autistic disorders could be explained by pregnancy complications or neonatal morbidity. METHODS: This Swedish, population-based, case-control study included 1216 case subjects with autistic disorders who were born between 1987 and 2002 and 6080 control subjects who were matched with respect to gender, birth year, and birth hospital. We assessed associations between gestational age and autistic disorders and adjusted for maternal, birth, and neonatal characteristics. Conditional logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs). RESULTS: Compared with infants born at term, the unadjusted ORs for autistic disorders among very and moderately preterm infants were 2.05 [95% CI: 1.26-3.34] and 1.55 [95% CI: 1.22-1.96], respectively. When we controlled for maternal, pregnancy, and birth characteristics, ORs were reduced to 1.48 [95% CI: 0.77-2.84] and 1.33 [95% CI: 0.98-1.81], respectively. When we also controlled for neonatal complications, ORs were 0.98 [95% CI: 0.45-2.16] and 1.25 [95% CI: 0.90-1.75], respectively. Reductions in risks of autistic disorders related to preterm birth were primarily attributable to preeclampsia, small-for-gestational age birth, congenital malformations, low Apgar scores at 5 minutes, and intracranial bleeding, cerebral edema, or seizures in the neonatal period. Neonatal hypoglycemia, respiratory distress, and neonatal jaundice were associated with increased risk of autistic disorders for term but not preterm infants. CONCLUSION: The increased risk of autistic disorders related to preterm birth is mediated primarily by prenatal and neonatal complications that occur more commonly among preterm infants.
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| 3. |
- Henriksson, Roger, et al.
(författare)
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Brain Tumors - Prognostic and Predictive Markers
- 2009
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Ingår i: Histological and Serological Tumor Markers and Gene Expression and Their Clinical Usefulness in Cancers. - Hauppauge : Nova Science Publishers, Inc.. - 9781607413820 ; , s. 53-75
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Bokkapitel (refereegranskat)abstract
- This review summarizes the status of prognostic and predictive markers in brain tumors with a focus on the most frequent tumors, gliomas. Brain tumors are a heterogeneous group of different tumors with a huge variation in outcome. Although the most common tumor, high-grade malignant glioma, still has a dismal prognosis, the last years have seen a significant improvement in the management in this tumor as well as in most other brain tumors. Age, tumor grade and KPS are still the most reliable prognostic and predictive variables available for patients with brain tumors. Although chromosome 1p/19q co-deletion and methylation status of the promoter of the MGMT gene (encoding O6-methylguanine-DNA methyl transferase) have been identified as the most promising potential predictors of response to chemotherapy in malignant gliomas, there are as yet no reliable biomarkers for tumour grading or tumour monitoring in the clinical setting.
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| 4. |
- Johansson, Linda, 1977-
(författare)
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Acoustic Manipulation of Particles and Fluids in Microfluidic Systems
- 2009
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The downscaling and integration of biomedical analyses onto a single chip offers several advantages in speed, cost, parallelism and de-centralization. Acoustic radiation forces are attractive to use in these applications since they are strong, long-range and gentle. Lab-on-a-chip operations such as cell trapping, particle fluorescence activated cell sorting, fluid mixing and particle sorting performed by acoustic radiation forces are exploited in this thesis. Two different platforms are designed, manufactured and evaluated.
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| 5. |
- Johansson, Linda, et al.
(författare)
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Effective mixing of laminar flows at a density interface by an integrated ultrasonic transducer
- 2009
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Ingår i: Lab on a Chip. - : Royal Society of Chemistry (RSC). - 1473-0197 .- 1473-0189. ; 9:2, s. 297-304
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Tidskriftsartikel (refereegranskat)abstract
- An acoustic mixer for glass channel microfluidic systems is presented. An acoustic standing wave, perpendicular to the fluid flow, is generated by the excitation of a miniaturized piezoelectric transducer operated around 10 MHz. The transducer is fabricated into a planar printed circuit board structure, constituting the bottom channel wall, which makes the mixer simple to integrate with a wide selection of microfluidic channel designs. The mixing occurs at a fluid-fluid density interface due to the acoustic radiation force; an analytical expression is derived to qualitatively describe this phenomenon. Only a small density difference in the range of 2–5% is required to achieve 150–270% peak broadening of a fluorescent sample between sheath flows, which we use as a measure of the mixing efficiency. The mixing efficiency is measured with regard to its sensitivity to the density difference, the fluid velocity and the transducer driving frequency. Transducers at different positions along the microchannel make it possible to compare the mixing of straight versus diagonal flows across the transducer surface. We finally demonstrate enhanced chemical lysis of E. coli K12 cells in the device due to active fluid mixing.
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| 6. |
- Johansson, Linda, et al.
(författare)
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On-chip fluorescence activated cell sorting by an integrated miniaturized ultrasonic transducer
- 2009
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Ingår i: Analytical Chemistry. - : American Chemical Society (ACS). - 0003-2700 .- 1520-6882. ; 81:13, s. 5188-5196
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Tidskriftsartikel (refereegranskat)abstract
- An acoustic microfluidic system for miniaturized fluorescence-activated cell sorting (mu FACS) is presented. By excitation of a miniaturized piezoelectric transducer at 10 MHz in the microfluidic channel bottom, an acoustic standing wave is formed in the channel. The acoustic radiation force acting on a density interface causes fluidic movement, and the particles or cells on either side of the fluid interface are displaced in a direction perpendicular to the standing wave direction. The small size of the transducer enables individual manipulation of cells passing the transducer surface. At constant transducer activation the system was shown to accomplish up to 700 mu m sideways displacement of 10 mu m beads in a 1 mm wide channel. This is much larger than if utilizing the acoustic radiation force acting directly on particles, where the limitation in maximum displacement is between a node and an antinode which at 10 MHz is 35 mu m. In the automatic sorting setup, the system was demonstrated to successfully sort single cells of E-GFP expressing beta-cells.
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| 7. |
- Yantchev, Ventsislav, et al.
(författare)
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Interface acoustic wave based manipulation of sub-micrometer particles in microfluidic channels
- 2009
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Ingår i: Proceedings. 2009 Inernational IEEE Ultrasonic Symposium.
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Konferensbidrag (refereegranskat)abstract
- The work in question addresses the issue of continuous flow particle manipulation in liquid media with particularemphasis on particles with micron and sub-micron dimensions.The subject is of significant relevance for a range of biotechnological applications and in particular for lab-on-chip ones.Particle manipulation utilizing Interface Acoustic Waves (IAW)is proposed for the first time. Manipulation of submicron sized particles is successfully demonstrated in a streaming free regime.
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| 8. |
- Arbat, Anna, et al.
(författare)
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Design and validation of the control circuits for a micro-cantilever tool for a micro-robot
- 2009
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Ingår i: Sensors and Actuators A-Physical. - P.O. Box 211, Amsterdam, 1000 AE, Netherlands : Elsevier. - 0924-4247 .- 1873-3069. ; 153:1, s. 76-83
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Tidskriftsartikel (refereegranskat)abstract
- The objective of this paper is to present the design and validation of a cantilever-based contact sensing system for a micro-robot. Key elements of the fabrication process of the sensor and the electrical model extraction used to design the control electronics are described. The architecture used for the sensor corresponds to a micro-cantilever fabricated of piezoelectric-polyvinylidene fluoride-trifluoroethylene stacked in a multilayer structure with the possibility of both actuating and sensing. A lumped electro mechanical equivalent model of the micro-cantilever was used to design the control electronics for the cantilever. A driving signal from, the control system is used to vibrate the cantilever at its first mechanical resonance frequency. The control system contains an analog front-end to measure the sensor output signal and a digital control unit designed to track and keep the resonance frequency of the cantilever. By integrating the cantilever control system is integrated in the application specified integrated circuit used to control of the circuit is simplyfied and very compact. Experimental results show a similar behavior between the electrical model and the fabricated system, and the deviations between the model and the measured structure are analyzed. The results also show that the designed control system is capable to detect the resonance frequency of the system and to actuate despite small deviations in process parameters of different batches of cantilevers. The whole system was designed to be integrated into an autonomous micro-robot, although it can be used in other applications.
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| 9. |
- Butt, Rehman, et al.
(författare)
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Where do we go now? Anytime algorithms for path planning
- 2009
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Konferensbidrag (refereegranskat)abstract
- Commercial computer games has become one of the largest industries in the area of entertainment. Real Time Strategy (Rts) based games is one of the most important among different types of computer games and is also considered to be a good research platform within Artificial Intelligence (Ai). There exists a number of algorithms that can deal with the Ai related problems of this domain, e.g. the ones of getting as cheap or fast as possible from one point to another (i.e. path planning). However most of the algorithms used in academia are better suited for problems that do not need to be solved within tight time frames. Anytime algorithms (Aa) are algorithms that can be stopped at any point in time and yet come up with a preliminary solution. We believe that by making algorithms anytime, we can optimize their behaviors to better suit the Rts domain. This study will introduce a tool for evaluating path planning algorithms and compare the performances of A*, Recursive Best First Search (Rbfs), Potential Fields (Pf) and their anytime versions for the path planning problem.
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| 10. |
- Bylesjö, Max, et al.
(författare)
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Integrated analysis of transcript, protein and metabolite data to study lignin biosynthesis in hybrid aspen
- 2009
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Ingår i: Journal of Proteome Research. - : American Chemical Society (ACS). - 1535-3893 .- 1535-3907. ; 8:1, s. 199-210
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Tidskriftsartikel (refereegranskat)abstract
- Tree biotechnology will soon reach a mature state where it will influence the overall supply of fiber, energy and wood products. We are now ready to make the transition from identifying candidate genes, controlling important biological processes, to discovering the detailed molecular function of these genes on a broader, more holistic, systems biology level. In this paper, a strategy is outlined for informative data generation and integrated modeling of systematic changes in transcript, protein and metabolite profiles measured from hybrid aspen samples. The aim is to study characteristics of common changes in relation to genotype-specific perturbations affecting the lignin biosynthesis and growth. We show that a considerable part of the systematic effects in the system can be tracked across all platforms and that the approach has a high potential value in functional characterization of candidate genes.
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