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Genome-wide associa...
Genome-wide association analysis identifies six new loci associated with forced vital capacity
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Loth, Daan W (author)
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Artigas, María Soler (author)
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Gharib, Sina A (author)
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show more...
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Wain, Louise V (author)
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Franceschini, Nora (author)
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Koch, Beate (author)
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Pottinger, Tess D (author)
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Smith, Albert Vernon (author)
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Duan, Qing (author)
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Oldmeadow, Chris (author)
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Lee, Mi Kyeong (author)
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Strachan, David P (author)
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James, Alan L (author)
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Huffman, Jennifer E (author)
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Vitart, Veronique (author)
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Ramasamy, Adaikalavan (author)
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Wareham, Nicholas J (author)
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Kaprio, Jaakko (author)
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Wang, Xin-Qun (author)
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Trochet, Holly (author)
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Kähönen, Mika (author)
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Flexeder, Claudia (author)
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Albrecht, Eva (author)
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Lopez, Lorna M (author)
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de Jong, Kim (author)
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Thyagarajan, Bharat (author)
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Alves, Alexessander Couto (author)
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- Enroth, Stefan (author)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi,Science for Life Laboratory, SciLifeLab,Gyllensten
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Omenaas, Ernst (author)
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Joshi, Peter K (author)
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- Fall, Tove (author)
- Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab
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Viñuela, Ana (author)
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Launer, Lenore J (author)
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Loehr, Laura R (author)
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Fornage, Myriam (author)
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Li, Guo (author)
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Wilk, Jemma B (author)
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Tang, Wenbo (author)
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Manichaikul, Ani (author)
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Lahousse, Lies (author)
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Harris, Tamara B (author)
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North, Kari E (author)
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Rudnicka, Alicja R (author)
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Hui, Jennie (author)
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Gu, Xiangjun (author)
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Lumley, Thomas (author)
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Wright, Alan F (author)
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Hastie, Nicholas D (author)
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Campbell, Susan (author)
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Kumar, Rajesh (author)
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Pin, Isabelle (author)
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Scott, Robert A (author)
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Pietiläinen, Kirsi H (author)
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Surakka, Ida (author)
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Liu, Yongmei (author)
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Holliday, Elizabeth G (author)
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Schulz, Holger (author)
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Heinrich, Joachim (author)
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Davies, Gail (author)
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Vonk, Judith M (author)
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Wojczynski, Mary (author)
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Pouta, Anneli (author)
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- Johansson, Åsa (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Institutionen för immunologi, genetik och patologi,Uppsala kliniska forskningscentrum (UCR)
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Wild, Sarah H (author)
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- Ingelsson, Erik (author)
- Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab
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Rivadeneira, Fernando (author)
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Völzke, Henry (author)
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Hysi, Pirro G (author)
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Eiriksdottir, Gudny (author)
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Morrison, Alanna C (author)
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Rotter, Jerome I (author)
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Gao, Wei (author)
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Postma, Dirkje S (author)
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White, Wendy B (author)
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Rich, Stephen S (author)
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Hofman, Albert (author)
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Aspelund, Thor (author)
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Couper, David (author)
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Smith, Lewis J (author)
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Psaty, Bruce M (author)
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Lohman, Kurt (author)
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Burchard, Esteban G (author)
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Uitterlinden, André G (author)
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Garcia, Melissa (author)
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Joubert, Bonnie R (author)
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McArdle, Wendy L (author)
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Musk, A Bill (author)
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Hansel, Nadia (author)
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Heckbert, Susan R (author)
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Zgaga, Lina (author)
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van Meurs, Joyce B J (author)
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Navarro, Pau (author)
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Rudan, Igor (author)
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Oh, Yeon-Mok (author)
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Redline, Susan (author)
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Jarvis, Deborah L (author)
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Zhao, Jing Hua (author)
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Rantanen, Taina (author)
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O'Connor, George T (author)
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Ripatti, Samuli (author)
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Scott, Rodney J (author)
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Karrasch, Stefan (author)
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Grallert, Harald (author)
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Gaddis, Nathan C (author)
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Starr, John M (author)
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Wijmenga, Cisca (author)
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Minster, Ryan L (author)
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Lederer, David J (author)
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Pekkanen, Juha (author)
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- Gyllensten, Ulf (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Institutionen för immunologi, genetik och patologi
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Campbell, Harry (author)
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Morris, Andrew P (author)
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Gläser, Sven (author)
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Hammond, Christopher J (author)
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Burkart, Kristin M (author)
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Beilby, John (author)
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Kritchevsky, Stephen B (author)
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Gudnason, Vilmundur (author)
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Hancock, Dana B (author)
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Williams, O Dale (author)
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Polasek, Ozren (author)
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Zemunik, Tatijana (author)
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Kolcic, Ivana (author)
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Petrini, Marcy F (author)
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Wjst, Matthias (author)
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Kim, Woo Jin (author)
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Porteous, David J (author)
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Scotland, Generation (author)
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Smith, Blair H (author)
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Viljanen, Anne (author)
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Heliövaara, Markku (author)
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Attia, John R (author)
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Sayers, Ian (author)
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Hampel, Regina (author)
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Gieger, Christian (author)
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Deary, Ian J (author)
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Boezen, H Marike (author)
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Newman, Anne (author)
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Jarvelin, Marjo-Riitta (author)
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Wilson, James F (author)
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- Lind, Lars (author)
- Uppsala universitet,Kardiovaskulär epidemiologi
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Stricker, Bruno H (author)
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Teumer, Alexander (author)
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Spector, Timothy D (author)
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- Melén, Erik (author)
- Karolinska Institutet
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Peters, Marjolein J (author)
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Lange, Leslie A (author)
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Barr, R Graham (author)
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Bracke, Ken R (author)
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Verhamme, Fien M (author)
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Sung, Joohon (author)
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Hiemstra, Pieter S (author)
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Cassano, Patricia A (author)
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Sood, Akshay (author)
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Hayward, Caroline (author)
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Dupuis, Josée (author)
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Hall, Ian P (author)
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Brusselle, Guy G (author)
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Tobin, Martin D (author)
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London, Stephanie J (author)
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(creator_code:org_t)
- 2014-06-15
- 2014
- English.
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In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 46, s. 669-677
- Related links:
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http://www.tara.tcd....
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Subject headings
Close
- Forced vital capacity (FVC), a spirometric measure of pulmonary function, reflects lung volume and is used to diagnose and monitor lung diseases. We performed genome-wide association study meta-analysis of FVC in 52,253 individuals from 26 studies and followed up the top associations in 32,917 additional individuals of European ancestry. We found six new regions associated at genome-wide significance (P < 5 × 10(-8)) with FVC in or near EFEMP1, BMP6, MIR129-2-HSD17B12, PRDM11, WWOX and KCNJ2. Two loci previously associated with spirometric measures (GSTCD and PTCH1) were related to FVC. Newly implicated regions were followed up in samples from African-American, Korean, Chinese and Hispanic individuals. We detected transcripts for all six newly implicated genes in human lung tissue. The new loci may inform mechanisms involved in lung development and the pathogenesis of restrictive lung disease.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Loth, Daan W
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Artigas, María S ...
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Gharib, Sina A
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Wain, Louise V
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Franceschini, No ...
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Koch, Beate
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show more...
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Pottinger, Tess ...
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Smith, Albert Ve ...
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Duan, Qing
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Oldmeadow, Chris
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Lee, Mi Kyeong
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Strachan, David ...
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James, Alan L
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Huffman, Jennife ...
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Vitart, Veroniqu ...
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Ramasamy, Adaika ...
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Wareham, Nichola ...
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Kaprio, Jaakko
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Wang, Xin-Qun
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Trochet, Holly
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Kähönen, Mika
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Flexeder, Claudi ...
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Albrecht, Eva
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Lopez, Lorna M
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de Jong, Kim
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Thyagarajan, Bha ...
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Alves, Alexessan ...
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Enroth, Stefan
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Omenaas, Ernst
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Joshi, Peter K
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Fall, Tove
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Viñuela, Ana
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Launer, Lenore J
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Loehr, Laura R
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Fornage, Myriam
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Li, Guo
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Wilk, Jemma B
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Tang, Wenbo
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Manichaikul, Ani
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Lahousse, Lies
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Harris, Tamara B
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North, Kari E
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Rudnicka, Alicja ...
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Hui, Jennie
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Gu, Xiangjun
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Lumley, Thomas
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Wright, Alan F
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Hastie, Nicholas ...
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Campbell, Susan
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Kumar, Rajesh
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Pin, Isabelle
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Scott, Robert A
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Pietiläinen, Kir ...
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Surakka, Ida
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Liu, Yongmei
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Holliday, Elizab ...
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Schulz, Holger
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Heinrich, Joachi ...
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Davies, Gail
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Vonk, Judith M
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Wojczynski, Mary
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Pouta, Anneli
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Johansson, Åsa
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Wild, Sarah H
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Ingelsson, Erik
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Rivadeneira, Fer ...
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Völzke, Henry
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Hysi, Pirro G
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Eiriksdottir, Gu ...
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Morrison, Alanna ...
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Rotter, Jerome I
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Gao, Wei
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Postma, Dirkje S
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White, Wendy B
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Rich, Stephen S
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Hofman, Albert
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Aspelund, Thor
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Couper, David
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Smith, Lewis J
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Psaty, Bruce M
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Lohman, Kurt
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Burchard, Esteba ...
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Uitterlinden, An ...
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Garcia, Melissa
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Joubert, Bonnie ...
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McArdle, Wendy L
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Musk, A Bill
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Hansel, Nadia
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Heckbert, Susan ...
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Zgaga, Lina
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van Meurs, Joyce ...
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Navarro, Pau
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Rudan, Igor
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Oh, Yeon-Mok
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Redline, Susan
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Jarvis, Deborah ...
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Zhao, Jing Hua
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Rantanen, Taina
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O'Connor, George ...
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Ripatti, Samuli
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Scott, Rodney J
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Karrasch, Stefan
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Grallert, Harald
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Gaddis, Nathan C
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Starr, John M
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Wijmenga, Cisca
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Minster, Ryan L
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Lederer, David J
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Pekkanen, Juha
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Gyllensten, Ulf
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Campbell, Harry
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Morris, Andrew P
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Gläser, Sven
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Hammond, Christo ...
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Burkart, Kristin ...
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Beilby, John
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Kritchevsky, Ste ...
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Gudnason, Vilmun ...
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Hancock, Dana B
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Williams, O Dale
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Polasek, Ozren
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Zemunik, Tatijan ...
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Kolcic, Ivana
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Petrini, Marcy F
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Wjst, Matthias
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Kim, Woo Jin
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Porteous, David ...
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Scotland, Genera ...
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Smith, Blair H
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Viljanen, Anne
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Heliövaara, Mark ...
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Attia, John R
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Sayers, Ian
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Hampel, Regina
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Gieger, Christia ...
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Deary, Ian J
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Boezen, H Marike
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Newman, Anne
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Jarvelin, Marjo- ...
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Wilson, James F
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Lind, Lars
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Stricker, Bruno ...
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Teumer, Alexande ...
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Spector, Timothy ...
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Melén, Erik
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Peters, Marjolei ...
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Lange, Leslie A
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Barr, R Graham
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Bracke, Ken R
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Verhamme, Fien M
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Sung, Joohon
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Hiemstra, Pieter ...
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Cassano, Patrici ...
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Sood, Akshay
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Hayward, Carolin ...
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Dupuis, Josée
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Hall, Ian P
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Brusselle, Guy G
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Tobin, Martin D
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London, Stephani ...
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show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
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and Basic Medicine
-
and Medical Genetics
- Articles in the publication
-
Nature Genetics
- By the university
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Uppsala University
-
Karolinska Institutet