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- Peiser, M., et al.
(författare)
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Allergic contact dermatitis: Epidemiology, molecular mechanisms, in vitro methods and regulatory aspects
- 2012
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Ingår i: Cellular and Molecular Life Sciences. - : Springer Science and Business Media LLC. - 1420-682X .- 1420-9071. ; 69:5, s. 763-781
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Forskningsöversikt (refereegranskat)abstract
- Contact allergies are complex diseases, and one of the important challenges for public health and immunology. The German 'Federal Institute for Risk Assessment' hosted an 'International Workshop on Contact Dermatitis'. The scope of the workshop was to discuss new discoveries and developments in the field of contact dermatitis. This included the epidemiology and molecular biology of contact allergy, as well as the development of new in vitro methods. Furthermore, it considered regulatory aspects aiming to reduce exposure to contact sensitisers. An estimated 15-20% of the general population suffers from contact allergy. Workplace exposure, age, sex, use of consumer products and genetic predispositions were identified as the most important risk factors. Research highlights included: advances in understanding of immune responses to contact sensitisers, the importance of autoxidation or enzyme-mediated oxidation for the activation of chemicals, the mechanisms through which hapten-protein conjugates are formed and the development of novel in vitro strategies for the identification of skin-sensitising chemicals. Dendritic cell cultures and structure-activity relationships are being developed to identify potential contact allergens. However, the local lymph node assay (LLNA) presently remains the validated method of choice for hazard identification and characterisation. At the workshop the use of the LLNA for regulatory purposes and for quantitative risk assessment was also discussed. © The Author(s) 2011.
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| 2. |
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| 3. |
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| 4. |
- Rockström, Johan, et al.
(författare)
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A safe operating space for humanity
- 2013
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Ingår i: The Future of Nature. - : Yale University Press. - 9780300184617 ; , s. 491-501
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Bokkapitel (refereegranskat)
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| 5. |
- Vanhomwegen, J, et al.
(författare)
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Diagnostic assays for Crimean-Congo hemorrhagic fever
- 2012
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Ingår i: Emerging infectious diseases. - : Centers for Disease Control and Prevention (CDC). - 1080-6059 .- 1080-6040. ; 18:12, s. 1958-1965
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Tidskriftsartikel (refereegranskat)
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| 10. |
- Goienetxea Uriarte, Ainhoa, et al.
(författare)
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Improved system design of an emergency department through simulation-based multiobjective-optimization
- 2014
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Konferensbidrag (refereegranskat)abstract
- Healthcare facilities, and especially emergency departments (ED), are usually characterized by its complexity due to the variability and stochastic nature of the processes involved in the system. The combination of different flows of patients, staff and resources also increments the complexity of this kind of facilities. In order to increase its efficiency, many researchers have proposed discrete-event simulation (DES) as a powerful improvement tool. However, DES can be a limited approach in the case a simulation model has too many combinations of input parameters, complex correlations between the input and output parameters and different objective functions. Hence, to find the best configuration of a complex system, an approach combining DES and meta-heuristic optimization becomes an even more powerful improvement technique. Simulation-based multiobjective-optimization (SMO) is a promising approach to generate multiple trade-off solutions particularly when multiple conflicting objectives exist within a complex system. The generated solutions provide decision makers with feasible and optimal alternatives to improve, modify or design healthcare systems. The aim of this paper is to present the work done at the ED of the regional Hospital of Skövde in Sweden, where SMO implemented in modeFromtier has been successfully applied. The result and methodology present a successful approach for decision makers in healthcare systems to reduce the waiting time of patients saving considerable time, money and resources.
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