| 1. |
- Brink Pinto, Andrés, et al.
(författare)
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Inledning
- 2022
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Ingår i: Kritiska blickar från marginalen : Reflektioner i spåren av Jens Rydström - Reflektioner i spåren av Jens Rydström. - : Department of Gender Studies, Lund University. - 9789180392938 - 9789180392945 ; , s. 11-22
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 2. |
- Alfredsson, Eva C., et al.
(författare)
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Industrial climate mitigation strategies and the remaining fair carbon budget – The case of Sweden
- 2024
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Ingår i: Next Sustainability. - 2949-8236. ; 3, s. 100031-100031
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Tidskriftsartikel (refereegranskat)abstract
- This article explores the climate mitigation strategies of the 15 industries with the largest carbon dioxide emissions in Sweden. Starting from two carbon budget alternatives, we analyse the mitigation projections of the companies in relation to what can be considered their fair share of the remaining carbon budget for Sweden.We furthermore determine the uncertainties associated with the strategies. The results suggest that if the communicated mitigation plans are implemented as planned, the companies overdraft our main, 1.5-degree, budget option but stay within the alternative 1.7-degree budget. The analysis shows, however, that the timing and efficiency of emission reductions are crucial.Already small delays or lower efficiency in implementation, result in evident overdrafts of also the alternative budget. There are also substantial political and technical risks which can prevent timely mitigations. The article makes a novel contribution by analyzing industries’ mitigation strategies relative to their share of the remaining carbon budget.The article demonstrates the importance of transparent industrial climate mitigation strategies and in particular the need for policymakers to set incentive structures to promote strategy implementation.
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| 3. |
- Alfredsson, Eva, 1963-, et al.
(författare)
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Investeringar för en rättvis klimatomställning
- 2023
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Annan publikation (populärvet., debatt m.m.)abstract
- Inom forskningsprogrammet FAIRTRANS har en workshop hållits om investeringars roll i klimatomställningen. Syftet var att lyfta fram olika gruppers behov av investeringar för en rättvis fossilfri framtid inom ramen för en svensk koldioxidbudget.
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| 4. |
- Alfredsson, Eva, 1963-, et al.
(författare)
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Investeringars betydelse för klimatomställningen
- 2023
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Rapport (populärvet., debatt m.m.)abstract
- Syftet med detta kunskapsunderlag är att förbereda för deltagande och dialog inför FAIRTRANS Workshop 2. Fokus för diskussionen är vilka investeringar som bör prioriteras för att Sverige ska nå en rättvis koldioxidbudget.
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| 5. |
- Broberg, Martin, et al.
(författare)
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Comparative genomics highlights the importance of drug efflux transporters during evolution of mycoparasitism in Clonostachys subgenus Bionectria (Fungi, Ascomycota, Hypocreales)
- 2021
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Ingår i: Evolutionary applications. - : Wiley. - 1752-4571. ; 14, s. 476-497
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Tidskriftsartikel (refereegranskat)abstract
- Various strains of the mycoparasitic fungal speciesClonostachys roseaare used commercially as biological control agents for the control of fungal plant diseases in agricultural crop production. Further improvements of the use and efficacy ofC. roseain biocontrol require a mechanistic understanding of the factors that determines the outcome of the interaction betweenC. roseaand plant pathogenic fungi. Here, we determined the genome sequences of 11Clonostachysstrains, representing five species inClonostachyssubgenusBionectria, and performed a comparative genomic analysis with the aim to identify gene families evolving under selection for gene gains or losses. Several gene families predicted to encode proteins involved in biosynthesis of secondary metabolites, including polyketide synthases, nonribosomal peptide syntethases and cytochrome P450s, evolved under selection for gene gains (p <= .05) in theBionectriasubgenus lineage. This was accompanied with gene copy number increases (p <= .05) in ATP-binding cassette (ABC) transporters and major facilitator superfamily (MFS) transporters predicted to contribute to drug efflux. MostClonostachysspecies were also characterized by high numbers of auxiliary activity (AA) family 9 lytic polysaccharide monooxygenases, AA3 glucose-methanol-choline oxidoreductases and additional carbohydrate-active enzyme gene families with putative activity (or binding) towards xylan and rhamnose/pectin substrates. Particular features of theC. roseagenome included expansions (p <= .05) of the ABC-B4 multidrug resistance transporters, the ABC-C5 multidrug resistance-related transporters and the 2.A.1.3 drug:H + antiporter-2 MFS drug resistance transporters. The ABC-G1 pleiotropic drug resistance transporter geneabcG6inC. roseawas induced (p <= .009) by exposure to the antifungalFusariummycotoxin zearalenone (1121-fold) and various fungicides. Deletion ofabcG6resulted in mutants with reduced (p < .001) growth rates on media containing the fungicides boscalid, fenhexamid and iprodione. Our results emphasize the role of biosynthesis of, and protection against, secondary metabolites inClonostachyssubgenusBionectria.
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| 6. |
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| 7. |
- He, Fei, et al.
(författare)
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FPR2 Shapes an Immune-Excluded Pancreatic Tumor Microenvironment and Drives T-cell Exhaustion in a Sex-Dependent Manner
- 2023
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Ingår i: Cancer Research. - : American Association for Cancer Research (AACR). - 0008-5472 .- 1538-7445. ; 83:10, s. 1628-1645
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Tidskriftsartikel (refereegranskat)abstract
- Sex-driven immune differences can affect tumor progression and the landscape of the tumor microenvironment. Deeper understanding of these differences in males and females can inform patient selection to improve sex-optimized immunotherapy treatments. In this study, single-cell RNA sequencing and protein analyses uncovered a subpopulation of myeloid cells in pancreatic lesions associated with an immune-excluded tumor phenotype and effector T-cell exhaustion exclusively in females. This myeloid subpopulation was positively correlated with poor survival and genetic signatures of M2-like macrophages and T-cell exhaustion in females. The G-protein coupled receptor formyl peptide receptor 2 (FPR2) mediated these immunosuppressive effects. In vitro, treatment of myeloid cells with a specific FPR2 antagonist prevented exhaustion and enhanced cytotoxicity of effector cells. Proteomic analysis revealed high expression of immunosuppressive secretory proteins PGE2 and galectin-9, enriched integrin pathway, and reduced proinflammatory signals like TNFα and IFNγ in female M2-like macrophages upon FPR2 agonist treatment. In addition, myeloid cells treated with FPR2 agonists induced TIM3 and PD-1 expression only in female T cells. Treatment with anti-TIM3 antibodies reversed T-cell exhaustion and stimulated their ability to infiltrate and kill pancreatic spheroids. In vivo, progression of syngeneic pancreatic tumors was significantly suppressed in FPR2 knockout (KO) female mice compared with wild-type (WT) female mice and to WT and FPR2 KO male mice. In female mice, inoculation of tumors with FPR2 KO macrophages significantly reduced tumor growth compared with WT macrophages. Overall, this study identified an immunosuppressive function of FPR2 in females, highlighting a potential sex-specific precision immunotherapy strategy.
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| 8. |
- Johansson, Mikael, 1987, et al.
(författare)
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Automation as an enabler: Passengers’ experience of travelling with a full-length automated bus and their expectations of a future public transport system
- 2023
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Ingår i: Transportation Research Procedia. - 2352-1465 .- 2352-1457. ; 72, s. 957-964
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Konferensbidrag (refereegranskat)abstract
- Twenty-two frequent public transport users experienced travelling with a fully automated, full-length bus on a test course that included nine simulated everyday traffic situations. Most participants experienced the journey as very positive and their trust in the automated system was high. In general, they were positive about using automated buses in the future but believed that this would not improve their travelling experience or change their travel behaviour without additional modifications to the system, such as dedicated public transport lanes etc. Many believed that the introduction of automated buses could create conditions for increased access to transport in rural areas and that the automated technology might enable new services that would have a great impact on public transport development, contributing a more individual, efficient and flexible public transport system.
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| 9. |
- Lindgren, Oskar, et al.
(författare)
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Exploring sufficiency in energy policy : insights from Sweden
- 2023
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Ingår i: Sustainability. - Stockholm : Taylor & Francis. - 1548-7733. ; 19:1
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Tidskriftsartikel (refereegranskat)abstract
- Energy efficiency and renewable energy strategies have been insufficient in achieving rapid and profound reductions of energy-related greenhouse-gas (GHG) emissions. Consequently, energy sufficiency has gained attention as a complementary strategy over the past two decades. Yet, most research on energy sufficiency has been theoretical and its implementation in policy limited. This study draws on the growing sufficiency literature to examine the presence of sufficiency as a strategy for reducing energy-related GHG emissions in Sweden, a country often regarded as a "climate-progressive" country. By conducting a keyword and content analysis of energy policies and parliamentary debates during four governmental terms of office (2006-2022), this research explores the extent to which sufficiency is integrated into Swedish energy policy, as well as potential barriers to its adoption. The analyses revealed a scarcity of sufficiency elements. Although some policies could potentially result in energy savings, they are infrequent and overshadowed by the prevailing emphasis on efficiency and renewable energy. Furthermore, Sweden lacks a target for sufficiency or absolute energy reductions. The main impediments to sufficiency implementation include the disregard of scientific evidence in the policy-making process and the perceived contradiction between sufficiency and industrial competitiveness. This study thus concludes that sufficiency at best remains at the periphery of Swedish energy policy. Given the reinforced ambitions within the European Union, this raises questions regarding the validity of Sweden's reputation as a climate-progressive country.
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| 10. |
- Moberg, Christina, et al.
(författare)
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De unga gör helt rätt när de stämmer staten
- 2022
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Ingår i: Aftonbladet. - 1103-9000.
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Tidskriftsartikel (populärvet., debatt m.m.)abstract
- 1 620 forskare och lärare i forskarvärlden: Vi ställer oss bakom Auroras klimatkrav
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